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Sidorov D.V.

City Clinical Oncology Hospital One Moscow City Healthcare Department

Troitsky A.A.

P.A. Herzen Moscow Oncology Research Institute — Branch of the National Medical Radiology Research Center of the Ministry of Health of Russia

Lozhkin M.V.

City Clinical Oncology Hospital One of the Moscow City Healthcare Department

Grishin N.A.

P.A. Herzen Moscow Oncology Research Institute — Branch of the National Medical Radiology Research Center of the Ministry of Health of Russia

Stepanyuk I.V.

P.A. Herzen Moscow Oncology Research Institute, Branch, National Medical Radiology Research Center

Immediate and long-term results of total mesorectumectomy for rectal cancer. A single-center prospective study

Authors:

Sidorov D.V., Troitsky A.A., Lozhkin M.V., Grishin N.A., Stepanyuk I.V.

More about the authors

Journal: P.A. Herzen Journal of Oncology. 2021;10(1): 5‑11

DOI: 10.17116/onkolog2021100115

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Table of contents

IMMEDIATE AND LONG-TERM RESULTS OF TOTAL MESORECTUMECTOMY FOR RECTAL CANCER. A SINGLE-CENTER PROSPECTIVE STUDY
IMMEDIATE AND LONG-TERM RESULTS OF TOTAL MESORECTUMECTOMY FOR RECTAL CANCER. A SINGLE-CENTER PROSPECTIVE STUDY

To cite this article:

Sidorov DV, Troitsky AA, Lozhkin MV, Grishin NA, Stepanyuk IV. Immediate and long-term results of total mesorectumectomy for rectal cancer. A single-center prospective study. P.A. Herzen Journal of Oncology. 2021;10(1):5‑11. (In Russ.)
https://doi.org/10.17116/onkolog2021100115

 
Подписка 2025-2 (P.A. Herzen Journal of Oncology)
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OBJECTIVE

To assess the influence of prognostic factors, including morphopathological ones, on the long-term results of treatment in patients with rectal cancer.

PATIENTS AND METHODS

A prospective, non-randomized, single-center study included 112 patients with histologically confirmed rectal cancer. All the patients underwent total mesorectumectomy, followed by detailed morphopathological examination of a removed specimen.

RESULTS

The immediate results were assessed in all the 112 patients. The postoperative mortality rate was 0.9%. The quality of total mesorectumectomy was assessed as good (mesorectal plane or Grade 3) in 55 (49.1%) cases, satisfactory (intra-mesorectal plane or Grade2) in 37 (33.0%), and poor (muscularis propria plane or Grade 1) in 20 (17.9%). Planned morphological examination revealed a positive circular resection margin (CRM+) in 40 (35.7%) cases of the 112 patients and a negative resection (CRM–) in 72 (64.3%) cases. A total of 111 patients were included in the analysis of long-term results. The median follow-up period was 72 months (range, 3-123) months. The total mesorectumectomy group had a five-year tumor-specific survival rate of 69%.

CONCLUSION

The intact circular resection margin (CRM–) is a factor that is independently associated with a higher tumor-specific survival rate.

Keywords:

rectal cancer
total mesorectumectomy
long-term treatment results
circular resection margin

Authors:

Sidorov D.V.

City Clinical Oncology Hospital One Moscow City Healthcare Department

Troitsky A.A.

P.A. Herzen Moscow Oncology Research Institute — Branch of the National Medical Radiology Research Center of the Ministry of Health of Russia

Lozhkin M.V.

City Clinical Oncology Hospital One of the Moscow City Healthcare Department

Grishin N.A.

P.A. Herzen Moscow Oncology Research Institute — Branch of the National Medical Radiology Research Center of the Ministry of Health of Russia

Stepanyuk I.V.

P.A. Herzen Moscow Oncology Research Institute, Branch, National Medical Radiology Research Center

Received:

09.11.2020

Accepted:

11.11.2020

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