Aim of study — to improve results of treatment of patients with non-muscle invasive bladder cancer (BC) by using photodynamic diagnostics and therapy by the domestic fluorescent video system. Material and methods. The study involved 134 patients, 102 (76.1%) men and 32 (23.9%) women, the gender ratio was 3.2: 1, the age ranged from 32 years to 81 years, the average age of the patients was 63±1 years. All patients (n=134) were divided into 2 groups: in the study group, in which transurethral electroresection (TUR) was performed, intraoperative photodynamic diagnosis and therapy were used (n=64, 47.7%); in the control group the traditional method of treatment in the volume of TUR (n=70, 52.3%) was used. The study used a domestic fluorescence video system with multispectral laser exposure developed by Institute of General Physics named after A.M. Prokhorov. To assess the effectiveness of treatment and to identify relapse of bladder cancer, patients underwent cystoscopy every 3 months for 2 years. Results. The advantages of the domestic video system are the better visualization of pathological processes in the bladder and the numerical determination of the concentration of the photosensibilizer at a given point in real time. The accuracy of the diagnostic method using the domestic apparatus in patients with BC is 97%. Photodynamic diagnosis and therapy, using a domestic fluorescent video system, in the complex treatment of patients with non-muscle-invasive BC is an effective method that improves the duration of the disease-free period in the study group compared to the control group by 27.7%. Conclusions. The obtained data indicate an increase in the efficiency of surgical treatment of patients with non-muscle invasive bladder cancer using a domestic fluorescent video system in comparison with traditional methods of treatment.