Objective — to compare the immediate and long-term results of open and laparoscopic surgical interventions (OSI and LSI) in patients with colorectal cancer, by using the experience of the regional oncology dispensary. Subjects and methods. The immediate and long-term results of treatment were analyzed in 153 patients (78 (51%) men and 75 (49%) women) with colorectal cancer. All the patients included in the investigation were operated on; 76 (49.7%) and 77 (50.3%) underwent OSI and LSI, respectively. Results. The patients included in the investigation were matched for gender, age, body mass index, ASA scores, tumor location and stage, and performed neoadjuvant treatment. Conversion was required in 14 (18.4%) cases. The median operative duration was shorter in patients who underwent OSI than that in those who used LSI with statistical significance (169 and 216 min, respectively; p<0.001). There were statistically significant differences in the amounts of intraoperative blood loss in the compared groups (270 and 80 ml in the OSI and LSI groups, respectively; p<0.001). Postoperative mortality was comparable in both groups (3.9% versus 2.6%; p= 0.6), while estimating the frequency of postoperative complications could not reveal significant differences either (35.1% versus 28.6%; p=0.4). The recovery time of gastrointestinal tract function was significantly shorter in the LSI group (2.5±1.5 days versus 3.2±1.5 days in the OSI group (p<0.001). In the LSI group, the length of hospital stay after surgery was significantly shorter (p<0.001). Two-year relapse-free and overall survival was comparable in both groups (p=0.5 and p=0.8). Conclusion. The use of laparoscopic techniques during surgery for colorectal cancer is safe and technically feasible and yields the best immediate results that are also equivalent to those in patients with two-year overall and relapse-free survival as compared with patients who have undergone open surgery.