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Rerberg A.G.

P.A. Herzen Moscow Oncology Research Institute, Branch, National Medical Radiology Research Center, Ministry of Health of Russia, Moscow, Russia

Kaprin A.D.

FGBU "Moskovskiĭ nauchno-issledovatel'skiĭ onkologicheskiĭ institut im. P.A. Gertsena" Minzdrava Rossii

Kostin A.A.

Herzen Moscow Oncology Research Institute of Healthcare Ministry of the Russian Federation — branch of National Medical Research Radiology Center

Novikova E.G.

Moskovskiĭ nauchno-issledovatel'skiĭ onkologicheskiĭ institut im. P.A. Gertsena

Volchenko N.N.

Moskovskiĭ nauchno-issledovatel'skiĭ onkologicheskiĭ institut im. P.A. Gertsena, Moskva

Chulkova O.V.

Moskovskiĭ nauchno-issledovatel'skiĭ onkologicheskiĭ institut im. P.A. Gertsena

Bolotina L.V.

FGBU "Moskovskiĭ nauchno-issledovatel'skiĭ onkologicheskiĭ institut im. P.A. Gertsena" Minzdravsotsrazvitiia Rossii

Mukhtarullina S.V.

P.A. Herzen Moscow Oncology Research Institute, Branch, National Medical Radiology Research Center, Ministry of Health of Russia, Moscow, Russia

Khokhrikov G.I.

P.A. Herzen Moscow Oncology Research Institute, Branch, National Medical Radiology Research Center, Ministry of Health of Russia, Moscow, Russia

Sidorov D.Yu.

P.A. Herzen Moscow Oncology Research Institute, Branch, National Medical Radiology Research Center, Ministry of Health of Russia, Moscow, Russia

Gevorkyan A.R.

P.A. Herzen Moscow Oncology Research Institute, Branch, National Medical Radiology Research Center, Ministry of Health of Russia, Moscow, Russia

Neoadjuvant combined chemotherapy for locally advanced carcinoma of the cervix uteri

Authors:

Rerberg A.G., Kaprin A.D., Kostin A.A., Novikova E.G., Volchenko N.N., Chulkova O.V., Bolotina L.V., Mukhtarullina S.V., Khokhrikov G.I., Sidorov D.Yu., Gevorkyan A.R.

More about the authors

Journal: P.A. Herzen Journal of Oncology. 2017;6(6): 32‑37

DOI: 10.17116/onkolog20176632-37

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Table of contents

NEOADJUVANT COMBINED CHEMOTHERAPY FOR LOCALLY ADVANCED CARCINOMA OF THE CERVIX UTERI
NEOADJUVANT COMBINED CHEMOTHERAPY FOR LOCALLY ADVANCED CARCINOMA OF THE CERVIX UTERI

To cite this article:

Rerberg AG, Kaprin AD, Kostin AA, et al. . Neoadjuvant combined chemotherapy for locally advanced carcinoma of the cervix uteri. P.A. Herzen Journal of Oncology. 2017;6(6):32‑37. (In Russ.)
https://doi.org/10.17116/onkolog20176632-37

Подписка 2025-2 (P.A. Herzen Journal of Oncology)
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The new possibilities of chemotherapy, including neoadjuvant intraarterial chemotherapy, for cervical cancer (CC) have been recently explored. The investigation enrolled 21 women with cervical cancer (сT1bN0M0 — cT3bN0M0). In all (100%) women, the tumors were morphologically presented with grade 1-3 squamous cell carcinoma. All the patients received 2 regional chemotherapy cycles using cisplatin at a dose of 75 mg/m2. On the following day, paclitaxel was systemically administered at a dose of 175 mg/m2. Tumor dimensions decreased in all the patients. The latter showed a clinical response as a reduction of pain syndrome and lack of pre-existing bleeding from the genital tract. Tumor response was evaluated according to the Response Evaluation Criteria in Solid Tumors (REСIST 1.1). Complete and partial tumor regression was recorded in 5 (24%) and 14 (66%) patients, respectively; tumor stabilization was seen in 1 (5%) woman. Tumor progression was diagnosed in 1 (5%) patient. The achieved objective response could subsequently realize a surgical treatment stage in 18 (85%) women; 2 (10%) patients could undergo radiation therapy; due to tumor progression as pulmonary metastases, systemic chemotherapy could be implemented in 1 (5%) patient. Preliminary analysis suggests that superselective intra-arterial chemotherapy in patients with Stage IB1-IIIB cervical cancer can achieve an objective response in 95% of the patients. A surgical treatment stage could be realized in 85% of patients.

Keywords:

primarily unresectable cervical cancer
intra-arterial injection of platinum
neoadjuvant chemotherapy
systemic taxane administration
combined therapy

Authors:

Rerberg A.G.

P.A. Herzen Moscow Oncology Research Institute, Branch, National Medical Radiology Research Center, Ministry of Health of Russia, Moscow, Russia

Kaprin A.D.

FGBU "Moskovskiĭ nauchno-issledovatel'skiĭ onkologicheskiĭ institut im. P.A. Gertsena" Minzdrava Rossii

Kostin A.A.

Herzen Moscow Oncology Research Institute of Healthcare Ministry of the Russian Federation — branch of National Medical Research Radiology Center

Novikova E.G.

Moskovskiĭ nauchno-issledovatel'skiĭ onkologicheskiĭ institut im. P.A. Gertsena

Volchenko N.N.

Moskovskiĭ nauchno-issledovatel'skiĭ onkologicheskiĭ institut im. P.A. Gertsena, Moskva

Chulkova O.V.

Moskovskiĭ nauchno-issledovatel'skiĭ onkologicheskiĭ institut im. P.A. Gertsena

Bolotina L.V.

FGBU "Moskovskiĭ nauchno-issledovatel'skiĭ onkologicheskiĭ institut im. P.A. Gertsena" Minzdravsotsrazvitiia Rossii

Mukhtarullina S.V.

P.A. Herzen Moscow Oncology Research Institute, Branch, National Medical Radiology Research Center, Ministry of Health of Russia, Moscow, Russia

Khokhrikov G.I.

P.A. Herzen Moscow Oncology Research Institute, Branch, National Medical Radiology Research Center, Ministry of Health of Russia, Moscow, Russia

Sidorov D.Yu.

P.A. Herzen Moscow Oncology Research Institute, Branch, National Medical Radiology Research Center, Ministry of Health of Russia, Moscow, Russia

Gevorkyan A.R.

P.A. Herzen Moscow Oncology Research Institute, Branch, National Medical Radiology Research Center, Ministry of Health of Russia, Moscow, Russia

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