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Salim N.

European Medical Center, Moscow, Russia

Shonus D.Kh.

Department of Radiation Oncology, European Medical Center, Moscow, Russia

Stolbovoy A.V.

Department of Radiology, Russian Medical Academy of Postgraduate Education, Ministry of Health of the Russian Federation, Moscow, Russia

Development of radiation therapy for breast cancer

Authors:

Salim N., Shonus D.Kh., Stolbovoy A.V.

More about the authors

Journal: P.A. Herzen Journal of Oncology. 2017;6(4): 59‑65

DOI: 10.17116/onkolog20176459-65

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Table of contents

DEVELOPMENT OF RADIATION THERAPY FOR BREAST CANCER
DEVELOPMENT OF RADIATION THERAPY FOR BREAST CANCER

To cite this article:

Salim N, Shonus DKh, Stolbovoy AV. Development of radiation therapy for breast cancer. P.A. Herzen Journal of Oncology. 2017;6(4):59‑65. (In Russ.)
https://doi.org/10.17116/onkolog20176459-65

Подписка 2026 Онкология. Журнал им. П.А. Герцена (P.A. Herzen Journal of Oncology)
МСФ на ЯМ
Использование инфографики авторами научных работ
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Abstract:

The paper considers the development and current state of radiation therapy techniques for breast cancer, the problem of selecting the clinical target volume, radiation complications, unsolved problems; and the area of current researches is elaborated. Special attention is paid to a rationale for an individual approach to radiation techniques for patients. The data obtained from an analysis of the literature suggest that there is a sufficiently high probability of yielding the good results of relapse-free and overall survival in patients with breast cancer; however, some patients are shown to have a risk for serious cosmetic, functional, and vital complications. The paper provides evidence that the currently used radiotherapy techniques should be improved. It is concluded that there should be necessary areas of further researches for the optimization of radiotherapy for breast cancer.

Keywords:

breast cancer
radiotherapy
3DCRT
IMRT
VMAT
complications
area of researches

Authors:

Salim N.

European Medical Center, Moscow, Russia

Shonus D.Kh.

Department of Radiation Oncology, European Medical Center, Moscow, Russia

Stolbovoy A.V.

Department of Radiology, Russian Medical Academy of Postgraduate Education, Ministry of Health of the Russian Federation, Moscow, Russia

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References:

  1. Grubbe EH. Priority in the therapeutic use of XRays. Radiology. 1933;21(2):156-162.
  2. Haagensen C, Stout AP. Carcinoma of the breast. II — Criteria of operability. Ann Surg. 1943;118:859-870,1032-1051.
  3. Den’gina NV, Rodionov VV. Radiation therapy of operable breast cancer after radical mastectomy: What? Where? When? Prakticheskaya onkologiya. 2010;11(4):221-227. (In Russ.).
  4. Den’gina NV. Greatest events in ongology in 2013. Radiation therapy: in focus — breast cancer. Prakticheskaya onkologiya. 2014;15(1):17-23. (In Russ.).
  5. Davydov MI, ed. Oncology. Clinical recommendations [Onkologiya. Klinicheskie rekomendatsii]. Moscow: Izdatel’skaya gruppa RONTs; 2015:307-336. (In Russ.).
  6. Zhukova LG, Zikiryakhodzhaev AD, Koroleva IA, Nazarenko AV, Parokonnaya AA, Petrovskii AV, Semiglazova TYu, Stepanova A.M., Trofimova OP, Tyulyandin SA, Frolova MA. Mammary cancer. Clinical recommendations [Rak molochnoi zhelezy. Klinicheskie rekomendatsii]. Moscow: Izdatel’skaya gruppa RONTs; 2017. (In Russ.).
  7. Kaprin AD, Starinskii VV, Petrova GV, eds. The state of oncological care for the population of Russia in 2012 [Sostoyanie onkologicheskoi pomoshchi naseleniyu Rossii v 2012]. Moscow: FGBU «MNIOI im. P.A. Gertsena» Minzdrava Rossii; 2013. (In Russ.).
  8. IARC Globocan, 2008. Available at: http://globocan.iarc.fr/old/factsheets/cancers/breast-new.asp
  9. Simonov KA, Startseva ZhA, Slonimskaya EM. Radiation therapy of breast cancer with account prognostic factors. Sibirskii onkologicheskii zhurnal. 2015;(1):76-83. (In Russ.).
  10. Kaprin AD, Starinskii VV, Petrova GV, eds. The state of oncological care for the population of Russia in 2013 [Sostoyanie onkologicheskoi pomoshchi naseleniyu Rossii v 2013]. Moscow: FGBU «MNIOI im. P.A. Gertsena» Minzdrava Rossii; 2014. (In Russ.).
  11. Perez CA. The critical need for accurate treatment planning and quality control in radiation therapy. Int J Radiat Oncol Biol Phys. 1977;2(7-8):815-818.
  12. Clarke M, Collins R, Darby S, et al. Effects of radiotherapy and of differences in the extent of surgery for early breast cancer on local recurrence and 15-year survival: an overview of the randomized trials. Lancet. 2005;366(9503):2087-2106. https://doi.org/10.1016/S0140-6736(05)67887-7
  13. Gebski V, Lagleva M, Keech A, Simes J, Langlands AO. Survival effects of postmastectomy adjuvant radiation therapy using biologically equivalent doses: aclinical perspective. J Natl Cancer Inst. 2006;98(1):26-38. https://doi.org/10.1093/jnci/djj002
  14. Early Breast Cancer Trialists’ Collaborative Group. Favourable and unfavourable effects on longterm survival of radiotherapy for early breast cancer: an overview of the randomized trials. Lancet. 2000;355(9217):1757-1770.
  15. McGale P, Taylor C, Correa C, Cutter D, Duane F, Ewertz M, et al.; EBCTCG (Early Breast Cancer Trialists’ Collaborative Group). Effect of radiotherapy after mastectomy and axillary surgery on 10-year recurrence and 20-year breast cancer mortality: meta-analysis of individual patient data for 8135 women in 22 randomized trials. Lancet. 2014;383(9935):2127-2135. https://doi.org/10.1016/S0140-6736(14)60488-8
  16. Taylor ME, Haffty BG, Rabinovitch R, Arthur DW, Halberg FE, Strom E.A, et al. ACR appropriateness criteria on postmastectomy radiotherapy expert panel on radiation oncology — breast. Int J Radiat Oncol Biol Phys. 2009;73(4):997-1002. https://doi.org/10.1016/j.ijrobp.2008.10.080
  17. Kurtz J. for the EUSOMA Working Party. The curative role of radiotherapy in the treatment of operable breast cancer. Eur J Cancer. 2002;38(15):1961-1974.
  18. Poortmans P. Evidence based radiation oncology: breast cancer. Radiother Oncol. 2007;84(1):84-101.
  19. Dragun AE, Huang B, Gupta S, Crew JB, Tucker TC. One decade later: trends and disparities in the application of post-mastectomy radiotherapy since the release of the American Society of Clinical Oncology clinical practice guidelines. Int J Radiat Oncol Biol Phys. 2012;83(5):591-596. https://doi.org/10.1016/j.ijrobp.2012.02.002
  20. Recht A, Edge S, Solin L, Robinson DS, Estabrook A, Fine RE, et al. Postmastectomy radiotherapy guidelines of the American Society of Clinical Oncology. J Clin Oncol. 2001;19(5):1539-1569.
  21. Kiricuta IC, Gotz U, Schwab F, et al. Target volume definition and target conformal irradiation technique for breast cancer patients. Acta Oncol. 2000;39(3):429-436.
  22. Munshi A, Prabhu A, Kunkler I. Post mastectomy radiotherapy in one to three lymph node positive breast cancer. Acta Oncol. 2012;51(4):547-550. https://doi.org/10.3109/0284186X.2011.633929
  23. Overgaard M, Hansen PS, Overgaard J, et al: Postoperative radiotherapy in high-risk premenopausal women with breast cancer who receive adjuvant chemotherapy. N Engl J Med. 1997;337:949-955.
  24. Overgaard M, Jensen MB, Overgaard J, et al. Postoperative radiotherapy in high-risk postmenopausal breast-cancer patients given adjuvant tamoxifen: Danish Breast Cancer Cooperative Group DBCG 82c randomized trial. Lancet. 1999;353:1641-1648.
  25. Ragaz A, Jackson SM, Le N, et al. Adjuvant radiotherapy and chemotherapy in node-positive premenopausal women with breast cancer. N Engl J Med. 1997;337:956-962.
  26. Whelan TJ, Olivotto IA, Parulekar WR, Ackerman I, Chua BH, Nabid A, et al; MA 20 Study Investigators. Regional nodal irradiation in early-stage breast cancer. N Engl J Med. 2015;373(4):307-316. https://doi.org/10.1056/NEJMoa1415340
  27. Recht A, Gray R, Davidson N, et al. Locoregional failure 10 years after mastectomy and adjuvant chemotherapy with or without tamoxifen without irradiation: experience of the Eastern Cooperative Oncology Group. J Clin Oncol. 1999;17:1689-1700.
  28. Grills IS, Kestin LL, Goldstein N, Mitchell C, et al. Risk factors for regional nodal failure after breast conserving therapy: regional nodal irradiation reduces rate of axillary failure in patients with four or more positive lymph nodes. Int J Radiat Oncol Biol Phys. 2003;56:658-670.
  29. Overgaard M, Nielsen HM, Overgaard J. Is the benefit of postmastectomy irradiation limited to patients with four or more positive nodes, as recommended in international consensus reports? A subgroup analysis of the DBCG 82 b&c randomized trials. Radiother Oncol. 2007;82(3):247-253. https://doi.org/10.1016/j.radonc.2007.02.001
  30. Freedman GM, Fowble BL, Nicolaou N, Sigurdson ER, Torosian MH, Boraas MC, Hoffman JP. Should internal mammary lymph nodes in breast cancer be a target for the radiation oncologist? Int J Radiat Oncol Biol Phys. 2000;46(4):805-814.
  31. Kaprin AD, Rozhkova NI, eds. Mammalogy. National leadership [Mammologiya. Natsional'noe rukovodstvo]. 2nd ed. Moscow: GEOTAR-Media; 2016. (In Russ.).
  32. Senkus E, Kyriakides S, Ohno S, Penault-Llorca F, Poortmans P, Rutgers E, et al.; ESMO Guidelines Committee. Primary breast cancer: ESMO Clinical Practice Guidelines for diagnosis, treatment and follow-up. Ann Oncol. 2015;26(Suppl.5):8-30. https://doi.org/10.1093/annonc/mdv298
  33. Smith BD, Bentzen SM, Correa CR. Fractionation for whole breast irradiation: an American Society for Radiation Oncology (ASTRO) evidence-based guideline. Int J Radiat Oncol Biol Phys. 2011;81(1):59-68. https://doi.org/10.1016/j.ijrobp.2010.04.042
  34. Trofimova OP, Tkachev SI, Khailenko VA, Kubasova IYu. Radiation therapy in the оrgan-сonserving treatment of patients with early breast cancer — what has changed? Vestnik Rossiiskogo gosudarstvennogo meditsinskogo universiteta. 2013;2:53-56. (In Russ.).
  35. Polgâ RC, Major T, Fodor J. High-dose-rate brachytherapy alone versus whole breast radiotherapy with or without tumor bed boost after breast-conserving surgery: seven-year results of a comparative study. Int J Radiat Oncol Biol Phys. 2004;60(4):1173-1178. https://doi.org/10.1016/j.ijrobp.2004.05.012
  36. Smith BD, Arthur DW, Buchholz TA. Accelerated partial breast irradiation consensus statement from the American Society for Radiation Oncology (ASTRO). J Am Coll Surg. 2009;209(2):269-277. https://doi.org/10.1016/j.jamcollsurg.2009.02.066
  37. Leonardi MC, Maisonneuve P, Mastropasqua MG, et al. How do the ASTRO consensus statement guidelines for the application of accelerated partial breast irradiation fit intraoperative radiotherapy? A retrospective analysis of patients treated at the European Institute of Oncology. Int J Radiat Oncol Biol Phys. 2012;83(3):806-813. https://doi.org/10.1016/j.ijrobp.2011.08.014
  38. Fletcher GH, McNeese MD, Oswald MJ. Long range results for breast cancer patients treated by radical mastectomy and postoperative radiation without adjuvant chemotherapy: An update. Int J Radiat Oncol Biol Phys. 1989;17(1):11-14.
  39. Koukourakis MI, Tsoutsou PG, Abatzoglou IM, et al. Hypofractionated and accelerated radiotherapy with subcutaneous amifostine cytoprotection as shortadjuvant regimen after breast-conserving surgery: interim report. Int J Radiat Oncol Biol Phys. 2009;74(4):1173-1180. https://doi.org/10.1016/j.ijrobp.2008.09.016
  40. Jagsi R, Griffith KA, Boike TP, et al. Differences in the acute toxic effects of breast radiotherapy by fractionation schedule. Comparative analysis of physician-assessed and patient-reported outcomes in a large multicenter cohort. JAMA Oncol. 2015;1(7):918-930. https://doi.org/10.1001/jamaoncol.2015.2590
  41. Bondarenko AV, Korytova LI, Maslyukova EA, Korytov OV, Muravnik EM. The comparison of the radiation load to the heart and the left anterior descending coronary artery for various modes of radiation treatment of the breast cancer patients. Opukholi zhenskoi reproduktivnoi sistemy. 2016;12(3):10-16. (In Russ.). https://doi.org/10.17650/1994-4098-2016-12-3-10-16
  42. Fisher B, Anderson S, Bryant J, et al. Twenty-year follow-up of a randomized trial comparing total mastectomy, lumpectomy, and lumpectomy plus irradiation for the treatment of invasive breast cancer. N Engl J Med. 2002;347(16):1233-1241. https://doi.org/10.1056/NEJMoa022152
  43. Feng M, Moran JM, Koelling T, et al. Development and validation of a heart atlas to study cardiac exposure to radiation following treatment for breast cancer. Int J Radiat Oncol Biol Phys. 2011;79(1):10-18. https://doi.org/10.1016/j.ijrobp.2009.10.058
  44. Muren LP, Maurstad G, Hafslund R, et al. Cardiac and pulmonary doses and complication probabilities in standard and conformal tangential irradiation in conservative management of breast cancer. Radiother Oncol. 2002;62(2):173-183.
  45. Schubert LK, Gondi V, Sengbusch E, et al. Dosimetric comparison of left-sided whole breast irradiation with 3DCRT, forward planned IMRT, inverse-planned IMRT, helical tomotherapy, and topotherapy. Radiother Oncol. 2011;100(2):241-246. https://doi.org/10.1016/j.radonc.2011.01.004
  46. Taylor CW, Povall JM, McGale P, et al. Cardiac dose from tangential breast cancer radiotherapy in the year 2006. Int J Radiat Oncol Biol Phys. 2008;72(2):501-507. https://doi.org/10.1016/j.ijrobp.2007.12.058
  47. Yin Y, Chen J, Sun T, et al. Dosimetric research on intensity-modulated arc radiotherapy planning for left breast cancer after breast-preservation surgery. Med Dosim. 2012;37(3):287-292. https://doi.org/10.1016/j.meddos.2011.11.001
  48. Hayden AJ, Rains M, Tiver K. Deep inspiration breath hold technique reduces heart dose from radiotherapy for left-sided breast cancer. J Med Imaging Radiat Oncol. 2012;56(4):464-472. https://doi.org/10.1111/j.1754-9485.2012.02405
  49. Darby SC, Ewertz M, McGale P, et al. Risk of ischemic heart disease in women after radiotherapy for breast cancer. N Engl J Med. 2013;368(11):987-998. https://doi.org/10.1056/NEJMoa1209825
  50. Korreman SS, Pederson AN, Aarup LR, et al. Reduction of cardiac and pulmonary complication probabilities after breathing adapted radiotherapy for breast cancer. Int J Radiat Oncol Biol Phys. 2006;65(5):1375-1380. https://doi.org/10.1016/j.ijrobp.2006.03.046
  51. Kirby AM, Evans PM, Donovan EM, et al. Prone versus supine positioning for whole and partial breast radiotherapy: a comparison of non-target tissue dosimetry. Radiother Oncol. 2010;96(2):178-184. https://doi.org/10.1016/j.radonc.2010.05.014
  52. Lymberis SC, deWyngaert JK, Parhar P, et al. Prospective assessment of optimal individual position (prone versus supine) for breast radiotherapy: volumetric and dosimetric correlations in 100 patients. Int J Radiat Oncol Biol Phys. 2012;84(4):902-909. https://doi.org/10.1016/j.ijrobp.2012.01.040
  53. Latty D, Stuart KE, Wang W, Ahern V. Review of deep inspiration breath-hold techniques for the treatment of breast cancer. J Med Radiat Sci. 2015;62(1):74-81. https://doi.org/10.1002/jmrs.96
  54. Vikström J, Hjelstuen MH, Mjaaland I, Dybvik KI. Cardiac and pulmonary dose reduction for tangentially irradiated breast cancer, utilizing deep inspiration breath-hold with audio-visual guidance, without compromising target coverage. Acta Oncol. 2011;50(1):42-50. https://doi.org/10.3109/0284186X.2010.512923
  55. Glatstein E. Intensity-modulated radiation therapy: the inverse, the converse, and the perverse. Semin Radiat Oncol. 2002;12(3):272-281. https://doi.org/10.1053/srao.2002.32433
  56. Kestin LL, Sharpe MB, Frazier RC, et al. Intensity modulation to improve dose uniformity with tangential breast radiotherapy: initial clinical experience. Int J Radiat Oncol Biol Phys. 2000;48:1559-1568.
  57. Potters L, Steinberg M, Wallner P, Hevezi J. How one defines intensity-modulated radiation therapy. Int J Radiat Oncol Biol Phys. 2003;56:609-610.
  58. Donovan E, Bleakley N, Denholm E, Evans P, Gothard L, Hanson J, et al. Randomised trial of standard 2D radiotherapy (RT) versus intensity modulated radiotherapy (IMRT) in patients prescribed breast radiotherapy. Radiother Oncol. 2007;82(3):254-264. https://doi.org/10.1016/j.radonc.2006.12.008
  59. Freedman GM, Anderson PR, Li J, Eisenberg DF, Hanlon AL, Wang L, et al. Intensity modulated radiation therapy (IMRT) decreases acute skin toxicity for women receiving radiation for breast cancer. Am J Clin Oncol. 2006;29(1):66-70. https://doi.org/10.1097/01.coc.0000197661.09628.03
  60. Pignol JP, Olivotto I, Rakovitch E, Gardner S, Sixel K, Beckham W, et al. A multicenter randomized trial of breast intensity-modulated radiation therapy to reduce acute radiation dermatitis. J Clin Oncol. 2008;26(13):2085-2092. https://doi.org/10.1200/JCO.2007.15.2488
  61. Lemanski C, Thariat J, Ampil FL, Bose S, Vock J, Davis R, et al; International Geriatric Radiotherapy Group. Image-guided radiotherapy for cardiac sparing in patients with left-sided breast cancer. Front Oncol. 2014;4:257. https://doi.org/10.3389/fonc.2014.00257
  62. Ozigit G, Gultekin M. Current role of modern radiotherapy techniques in the management of breast cancer. World J Clin Oncol. 2014;5(3):425-439. https://doi.org/10.5306/wjco.v5.i3.425
  63. Teoh M, Clark CH, Wood K, Whitaker S, Nisbet A. Volumetric modulated arc therapy: a review of current literature and clinical use in practice. Br J Radiol. 2011;84(1007):967-996. https://doi.org/10.1259/bjr/22373346
  64. Popescu CC, Olivotto IA, Beckham WA, et al. Volumetric modulated arc therapy improves dosimetry and reduces treatment time compared to conventional intensity-modulated radiotherapy for locoregional radiotherapy of left-sided breast cancer and internal mammary nodes. Int J Radiat Oncol Biol Phys. 2010;76:287-295.
  65. Johansen S, Cozzi L, Olsen DR. A planning comparison of dose patterns in organs at risk and predicted risk for radiation induced malignancy in the contralateral breast following radiation therapy of primary breast using conventional, IMRT and volumetric modulated arc treatment techniques. Acta Oncol. 2009;48:495-503. https://doi.org/10.1080/02841860802657227
  66. Nicolini G, Clivio A, Fogliata A, et al. Simultaneous integrated boost radiotherapy for bilateral breast: a treatment planning and dosimetric comparison for volumetric modulated arc and fixed field intensity modulated therapy. Radiat Oncol. 2009;4:27. https://doi.org/10.1186/1748-717X-4-27
  67. Muralidhar KR, Bhudevi Soubhagya, Shabbir Ahmed. Intensity modulated radiotherapy versus volumetric modulated arc therapy in breast cancer: A comparative dosimetric analysis. Int J Cancer Ther Oncol. 2015;3(2):1-6.
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