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Bazarnyi V.V.

Ural State Medical University

Salivary biomarkers of age-dependent processes (review)

Authors:

Bazarnyi V.V.

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Journal: Laboratory Service. 2022;11(3): 28‑33

DOI: 10.17116/labs20221103128

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Table of contents

SALIVARY BIOMARKERS OF AGE-DEPENDENT PROCESSES (REVIEW)
SALIVARY BIOMARKERS OF AGE-DEPENDENT PROCESSES (REVIEW)

To cite this article:

Bazarnyi VV. Salivary biomarkers of age-dependent processes (review). Laboratory Service. 2022;11(3):28‑33. (In Russ.)
https://doi.org/10.17116/labs20221103128

 
Подписка 2025-2 (Laboratory Service)
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The increase of the elderly and older people is a global demographic trend. This makes the problem of age-associated pathology relevant, including from the point of view of dental health. The purpose of the review is to summarize the data of modern literature on age-dependent laboratory parameters of mixed saliva (oral fluid) and to identify potential salivary biomarkers of aging. The primary source of information on salivary biomarkers were the medical bibliographic databases PubMed and Scopus, from which 39 full-text articles were selected by keywords, including 19 scientific descriptive reviews, 20 original articles, including 3 articles are the results of multicenter and large cohort studies, for 2017-2022. The relationship between the number of teeth, dentures with health and longevity were shown in the papers. Therefore, the attitude towards the concept of oral hygiene and treatment of dental diseases in the elderly age is changing. Currently, many theories and signs of aging have been proposed. Among them, various authors consider the most important integrative signs — cellular aging, depletion of the stem cells pool, disturbance of intercellular communication. Therefore, the search for potential salivary biomarkers of aging was focused in a group of laboratory indicators Among the parameters considered in the review, to date, the least developed assessment of the stem cell pool based on the results of a study of mixed saliva. Salivary parameters — beta-galactosidase associated with aging, IL-6 and tumor necrosis factor alpha (TNFα) can be considered the most relevant parameters for assessing cellular aging and disruption of intercellular communications. The special value of this approach is due to the fact that obtaining oral fluid of mixed saliva is the least traumatic and safest way to take biomaterial containing valuable clinical and laboratory information. However, the introduction of these parameters into gerontostomatology practice for monitoring the quality of aging requires further study to assess the clinical value of these laboratory parameters.

Keywords:

aging
biomarkers
oral fluid

Authors:

Bazarnyi V.V.

Ural State Medical University

Received:

28.07.2022

Accepted:

27.09.2022

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