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Sarkisian K.A.

Ural State Medical University

Zholudev S.E.

Ural State Medical University

Mandra Yu.V.

Ural State Medical University

Bazarnyi V.V.

Ural State Medical University

Marenkova M.L.

Ural State Medical University

Polushina L.G.

Ural State Medical University

Dynamics of total IgE concentration in oral fluid of patients with acrilate intolerancte

Authors:

Sarkisian K.A., Zholudev S.E., Mandra Yu.V., Bazarnyi V.V., Marenkova M.L., Polushina L.G.

More about the authors

Journal: Russian Journal of Stomatology. 2025;18(1): 18‑22

DOI: 10.17116/rosstomat20251801118

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Table of contents

DYNAMICS OF TOTAL IGE CONCENTRATION IN ORAL FLUID OF PATIENTS WITH ACRILATE INTOLERANCTE
DYNAMICS OF TOTAL IGE CONCENTRATION IN ORAL FLUID OF PATIENTS WITH ACRILATE INTOLERANCTE

To cite this article:

Sarkisian KA, Zholudev SE, Mandra YuV, Bazarnyi VV, Marenkova ML, Polushina LG. Dynamics of total IgE concentration in oral fluid of patients with acrilate intolerancte. Russian Journal of Stomatology. 2025;18(1):18‑22. (In Russ.)
https://doi.org/10.17116/rosstomat20251801118

Подписка 2025-2 (Russian Journal of Stomatology)
 
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RELEVANCE

The choice of construction materials is limited and, according to modern materials scientists, the main materials in the world in the next 20-30 years will remain plastics based on acrylates. The problem of construction materials that have a pathological effect on the oral mucosa and cause the phenomenon of intolerance to construction materials does not lose its relevance. However, today, there is a lack of data on the diagnosis of intolerance to construction materials. This study is aimed at studying and assessing changes in immunoglobulin E in intolerance to construction materials.

This study is devoted to assessing the effectiveness of laboratory diagnostics in case of intolerance to structural materials.

THE AIM

Is to evaluate the diagnostic value of immunoglobulin E (IgE) in patients with intolerance to structural materials in case of tooth loss

MATERIAL AND METHODS

48 patients were examined with intolerance to structural materials and 48 orthopedic patients without signs of intolerance to structural materials could be identified. A study of oral fluid was conducted, namely immunoglobulin E and an analysis of its level in patients with intolerance to structural materials, in comparison with the control group.

RESULTS AND DISCUSSION

Before replacing the base material, in patients with intolerance to construction materials, the value of immunoglobulin E was 11.20±6.81 IU/ml. After replacing the base material, the indicator was 9.23±6.88 IU/ml.

CONCLUSIONS

Despite the decrease in immunoglobulin E levels after replacing the base photopolymer material, which has less toxicity, in patients with intolerance to construction materials, in this sample of patients, we cannot talk about a statistically significant relationship between the base material and changes in IgE levels.

Keywords:

intolerance to construction materials
immunoglobulin E
oral fluid
methyl methacrylate
acrylic plastic
burning sensation of the oral cavity

Authors:

Sarkisian K.A.

Ural State Medical University

Zholudev S.E.

Ural State Medical University

Mandra Yu.V.

Ural State Medical University

Bazarnyi V.V.

Ural State Medical University

Marenkova M.L.

Ural State Medical University

Polushina L.G.

Ural State Medical University

Received:

12.12.2024

Accepted:

23.01.2025

List of references:

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  2. Kostić M, Igić M, Gligorijević N, et al. The Use of Acrylate Polymers in Dentistry. Polymers (Basel). 2022 Oct 25;14(21):4511. PMID: 36365504; PMCID: PMC9653800. https://doi.org/10.3390/polym14214511
  3. Diagnostics of intolerance of acrylic plastic dentures using the flowmetric method for determining histamine basophilamytema//Abstract of Cand. Sci. (Med.) Dissertation. 14.00.21. Moscow, 2005. (in Russian) https://medical-diss.com/medicina/diagnostika-neperenosimosti-protezov-iz-akrilovyh-plastmass-putem-primeneniya-floumetricheskogo-metoda-opredeleniya-gista
  4. https://doi.org/10.18481/2077-7566-21-17-4-136-139.  https://doi.org/10.18481/2077-7566-21-17-4-136-139.
  5. Russian Federation Patent for Invention No. 2793526C1/04.04.23. Sarkisyan KA, Zholudev SE, Bazarny VV. Method for diagnosing intolerance to acrylic structural materials of removable plate dentures in elderly and senile patients. https://patentimages.storage.googleapis.com/bd/e2/a9/b37246ee74086d/RU2793526C1.pdf
  6. Fletcher R, Harrison W, Crighton A. Dental material allergies and oral soft tissue reactions // Br Dent J. 2022 May;232(9):620-625. Epub 2022 May 13. PMID: 35562454. https://doi.org/10.1038/s41415-022-4195-9
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  8. Pathak JL, Yan Y, Zhang Q, et al. The role of oral microbiome in respiratory health and diseases. Respir Med. 2021 Aug-Sep; 185:106475. Epub 2021 May 20. PMID: 34049183. https://doi.org/10.1016/j.rmed.2021.106475
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