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Kudriavtseva L.V.

FGBU "Poliklinika #1" Upravleniia Delami Prezidenta RF

Gushchin A.E.

Central Research Institute of Epidemiology, Russian Federal Service for Supervision of Consumer Rights Protection and Human Welfare, Moscow, Russia

Normocenosis. Bacterial vaginosis. Comprehensive laboratory diagnosis of bacterial vaginosis: state-of-the-art

Authors:

Kudriavtseva L.V., Gushchin A.E.

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Journal: Laboratory Service. 2013;(1): 3‑24

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NORMOCENOSIS. BACTERIAL VAGINOSIS. COMPREHENSIVE LABORATORY DIAGNOSIS OF BACTERIAL VAGINOSIS: STATE-OF-THE-ART
NORMOCENOSIS. BACTERIAL VAGINOSIS. COMPREHENSIVE LABORATORY DIAGNOSIS OF BACTERIAL VAGINOSIS: STATE-OF-THE-ART

To cite this article:

Kudriavtseva LV, Gushchin AE. Normocenosis. Bacterial vaginosis. Comprehensive laboratory diagnosis of bacterial vaginosis: state-of-the-art. Laboratory Service. 2013;(1):3‑24. (In Russ.)

Подписка 2025 Лабораторная служба (Laboratory Service)
МСФ на ЯМ
Использование инфографики авторами научных работ
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Abstract:

The paper considers the vaginal environment in healthy women of reproductive age - normocenosis in different phases of the menstrual cycle; possible vaginal microenvironments through female life (puberty, menopause, pregnancy). Endo- and exogenous factors that can lead to microflora impairment in the vaginal biotope - bacterial vaginosis, as well as methods for diagnosis, including those for comprehensive diagnosis, treatment, and prevention of bacterial vaginosis, are viewed.

Keywords:

normocenosis
bacterial vaginosis
diagnosis
normocenosis
bacterial vaginosis
diagnosis
normocenosis
bacterial vaginosis
diagnosis

Authors:

Kudriavtseva L.V.

FGBU "Poliklinika #1" Upravleniia Delami Prezidenta RF

Gushchin A.E.

Central Research Institute of Epidemiology, Russian Federal Service for Supervision of Consumer Rights Protection and Human Welfare, Moscow, Russia

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References:

  1. Lentser A.A., Lentser Kh.P. Aktual'nye problemy mikroekologii cheloveka. V kn.: A

    Скачать статью в формате Adobe PDF

    utoflora cheloveka v norme i patologii i ee korrektsiya. Gor'kii 1988: 10-14.
  2. Svicheva A.M., Bashmakova M.A. Mikrobiotsenozy vlagalishcha i ikh regulyatsiya. Tez. dokl. nauch. konf. "Disbakteriozy i eubiotiki" M 1996: 33.
  3. Larsen B. Vaginal flora in health and disease. Clin Obstet Ginecol 1993; 36 (1): 107-211.
  4. Ailamazyan E.K., Ryabtseva I.T. Neotlozhnaya pomoshch' pri eksperimental'nykh sostoyaniyakh v ginekologii. SPb: Gippokrat 1992: 176.
  5. Nikonov A.P., Ankirskaya A.S., Nisilevich F.F. Akush i ginek 1993; 3: 20-23.
  6. Gravett M.G., Eschenbach D.A., Spigel-Brown C.A., Holmes K.K. Rapid diagnosis of amniotic fluid infection by gasliquid chromatography. N Engl J Med 1982; 306 (12): 725-728.
  7. Watts D.H., Eschenbach D.A., Kenny G.E. Early postpartum endometrities: the role of bacteria, general mycoplasmas and Chlamidia trachomatis. Obstet Gynecol 1989; 73: 52-60.
  8. Baranov A.N. Zhurn akush i zhen bol. Spets. vypusk 1995: 14.
  9. Martikainen Z.N. Korinebakterii, obnaruzhennye pri kol'pitakh i puerperal'nykh oslozhneniyakh. Klin lab diagn 1995; 4: 45-48.
  10. Hiller S.L., Krohn M.A., Rabe L., Klebanoff S.J., Eschenbach D.A. The normal vaginal flora, H2O2-producing Lactobacilli and bacterial vaginosis in pregnant women. Clin Infect Dis 1993; 16 (Suppl.): 273-281.
  11. Holst E., Wathne B., Mardh P.A. Bacterial vaginosis: microbiological and clinical findings. Eur J Clin Microbiol 1987; 6: 536-541.
  12. Spiegel C.A., Amsel R., Eshenbach D. Anaerobic bacteria in nonspecific vaginitis. N Engl Med 1980; 303: 271.
  13. Letuchikh A.A. Lechenie i profilaktika kol'pita. Akush ginek 1995; 7: 65-68.
  14. Larsen B. Mikroflora rodovykh putei v norme. Reproduktivnoe zdorov'e. Per. s angl. Obshchie infektsii T. 1. M: Meditsina 1988: 17-45.
  15. Batlett J.G., Moon N.E., Goldstein P.R. Cervical and vaginal bacterial flora: ecologic niches in the female lower genital tract. Am J Obstet Ginecol 1987; 130: 658-661.
  16. Galask R.P., Larsen B., Ohm M.S. Vaginal flora and it is role in disease entities. Clin Obstet Ginecol 1976; 19 (1): 61-81.
  17. Overmann B.A. The vaginal as en ecologyc system. Current anderstandin and clinical applications. J Nurse Midwifery 1993; 38 (3): 146-151.
  18. Hurley R., Stanley V.C., Leask B.G., de Louvois J. Microflora of the vagina during pregnancy. Soc Appl Bacteriol Simp Ser 1974; 30 (0): 155-185.
  19. Hillier S.L., Krohn M.A., Rabe L.K., Klebanoff S.L., Eschenbach D.A. The normal vaginal flora, H2O2-prodacing lactobacilli and bacterial vaginosis in pregnant women. Clin Infect Dis 1993; 16 (suppl): 273-281.
  20. Ohashi A. Clinicobacteriological study on microbial flora in the vaginal microbial flora according to the menstrual cycle. J Ap Ass Infect Dis 1980; 54 (7): 321-330.
  21. Akopyan T.E. Bakterial'nyi vaginoz i beremennost'. Akush i ginek 1996; 6: 3-5.
  22. Bartlett J.G., Polk B.F. Bacterial flora of the vagina: quantitative study. Rev Infect Dis 1984; 6: S67-S72.
  23. Oleen-Burkey M.A., Hiier S.L. Pregnancy complications associated with bacterial vaginosis and ther estimated costs. Infect Dis Obsted Gynecol 1995; 3: 149-157.
  24. Brown W.J. Variations in the vaginal bacterial flora: a preliminary report. Ann Intern Med 1982; 96: 6: (2): 931-934.
  25. Moberg P., Eneroth P., Harlin J. Cervical bacterial flora in infertile and pregnant women. Med Microbiol Immunol 1978; 165: 139-142.
  26. Ross J.M., Needhem J.R. Genital flora during pregnancy and colonization of the newborn. J Roy Souc Med 1980; 73 (2): 105-110.
  27. Hill G.B. Microbiology of bacterial vaginosis. Am J Obstet Gynecol 1993; 169: 450-454.
  28. Golbacre M.J., Watt B. Vaginal microbial flora in normal young women. Br. Med J 1979; 1: 1450-1453.
  29. Berg A.O., Heidrich F.E., Fihn S.D. Establiching the cause of genitourinary symptoms in women in a family practice: comparison of clinical examination and comprehensive microbiology. JAMA 1984; 251: 620-625.
  30. Harrnmann R., Kronibus A., Lang N., Werner H. Quantitative stadies on the vaginal flora of asymptomatic women and patients with vaginitis and vaginosis. Zbl Bakt Hyg 1987; 265: 451-461.
  31. Brown W.J., Sautter R.L., Pickrum H.M. Sequential quantitative evaluation of vaginal flora regularly menstruating normal women. J Clin Microbiol 1980; 11: 479-484.
  32. Paavonen J. Physiology and ecology of the vagina. Scand J Infect Dis 1980; 40: 31-35.
  33. Blackwell A.L., Phillips I., Fox A.R., Barlow D. Anaerobic vaginisis (non-specific vaginitis): clinical, microbiological, and therapeutic findings. Lancet 1983: 1379-1382.
  34. Corbach S.L., Menda K.B., Thadepalli H., Keith L. Anaerobic microflora of the cervix healthy women. Am J Obstet Ginecol 1973; 117: 1053-1055.
  35. Eshenbach D.A., Davick P.R., Williams B.L. Prevalence of hydrogen peroxide-producing Lactobacillus species in normal women and women with bacterial vaginosis. J Clin Microbiol 1989; 27: 251-225.
  36. Solov'eva I.V. Kharakteristika mikroflory vlagalishcha v norme i patologii. Dis. ... kand. med. nauk. M 1987.
  37. Skarin A., Sylwan J. Vaginal lactobacilli inhibiting growth of Gardnerella vaginalis, Mobiluncus and other bacterial species cultured from vaginal content of women with bacterial vaginosis. Acta Pathol Microbiol Immun 1987; 94: 399-403.
  38. Korshunov V.M., Kafarskaya L.I., Bagirova M.Sh. Izuchenie vliyaniya "Solkotrikhovata" na vaginal'nuyu mikrofloru u bol'nykh s papillomavirusnoi infektsiei v assotsiatsii s tservikal'noi intraepitelial'noi neoplaziei. ZhMEI 1994; 5: 13-17.
  39. Mehta A., Talwalkar J., Shetty C.V. Microbial flora of the vagina. J Microbiol Ther 1995; 23: 1-7.
  40. Korshunov V.M. Volodin N.N., Efimov B.A., Sarksov S.E. Mikroekologiya vlagalishcha. Korrektsiya mikroflory pri vaginal'nykh disbakteriozakh. M 1999; 80 s.
  41. Hillier S.L., Martius J., Krihn M. A case-control study of chorioamnionic infection ad histologic chorioamnionitis in ptematurity. N Engl J Med 1988; 319: 972-980.
  42. Furr P.M., Taylor-Robinson D. Prevalece and significance of Mucoplasma hominis and Ureaplasma urealyticum in the ures of non-veneral disease population. Epidemiol Infect 1987; 98: 353-359.
  43. McCormack W.M. The genital mycoplasmas. I N Engl J Med 1980; 301: 1063-1067.
  44. Redonodo-Lopes V., Cook R., Sobel J.D. Emerging role lactobacilli in the control and maintenance of the vaginal bacterial microflora. Rew Infect Dis 1990; 12: 856-872.
  45. Nazarova E.K., Gimmel'farb E.I., Sozaeva L.G. Disbakteriozy vlagalishcha: etiologiya, patogenez, klinika, laboratornaya diagnostika. M 2000; 7.
  46. McCormack W.M. The genital mycoplasmas. I N Engl J Med 1980; 302: 1003-1010.
  47. Hiller S., Holmes K.K. Bacterial vaginosis. In: Holmes K.K., Mardh P.A., Sparling P.F., Weisner P.J. Sexually transmitted diseases. 2 nd. New York: McGraw-Hill 1990; 547-560.
  48. Holmes K.K., Spiegel C., Amsel R. Nonspecific vaginisis. Scand J Infect Dis 1981; 26: S110-S114.
  49. Levison M.E., Carman L.C., Carrington E.R., Kayo D. Quantitative microflora of the vagina. Am J Obstet Ginecol 1977; 127: 80-85.
  50. Wilkins M., Thin R.N., Tabaqchall S. Quantitative bacteriology of the vaginal flora in genital disease. J Med Microbiol 1984; 18 (2): 217-231.
  51. Bairamova G.R. Klinicheskie osobennosti i effektivnost' ralichnykh metodov terapii bakterial'nogo vaginoza: Dis. ... kand. med. nauk. M 1992.
  52. Tyutyunnik V.L. Patogenez, diagnostika i metody lecheniya bakterial'nogo vaginoza. Farmateka 2005; 2 (98): 20-24.
  53. Thomason J.L., Gelbard S.M., Scaglione N.J. Bacterial vaginosis: current rewiew with indications for asymptomatic therapy. Am J Obstet Gynecol 2001; 165 (4): 1210-1217.
  54. Verboon-Maciolek M.A., Gerards L.J., Stoutenbeek P., van Loon A.M. Congenital infection: diagnostic serology of the mother not always definitive. Ned Tijdschr Geneeskd 2001; 145 (4): 153-156.
  55. Malazy O.T., Shariat M., Heshmat R., Majlesi F. et al. Vulvovaginal candidiasis and its related factors in diabetic women. Taiwan J Obstet Gynecol 2007; 46 (4): 399-404.
  56. Spiegel S.A., Eshenbach D., Amsel R., Holmes K.K. Curved anaerobic bacxteria in bacterial (nonspecific) vaginosis and their response to antimicrobial therapy. J Infect Dis 1983; 148: 817-822.
  57. Amsel R., Totten P.A., Spiegel C.A., Chen K.S. Nonspecific vaginitis: diagnostic criteria and microbial and epidemiologic assotiations. Am J Med 1983; 74: 14-22.
  58. Chapin-Robertson K. Use of molecular diagnostics in sexually transmitted diseases. Critical assessment. Diagn Mcrobiol Infect Dis 1993; 16 (2): 173-184.
  59. Akopyan T.E. Bakterial'nyi vaginoz i vaginal'nyi kandidoz u beremennykh (diagnostika i lechenie): Dis. ... kand. med. nauk. M 1996.
  60. Kira E.F. Bakterial'nyi vaginoz. SPb 2001; 364.
  61. Wathne V., Hoist E., Hovelius B. Erytromycin versus metronidazolein the treatment of bacterial vaginosis. Acta Obstet Gynecol Scand 1999; 72 (6): 470-471.
  62. Srinivasan S., Fredricks D. The Human Vaginal Bacterial Biota and Bacterial Vaginosis. Interdisciplinary Perspectives on Infectious Diseases 2008, Volume 2008.
  63. Meizoso T., Rivera T., Fernandez-Acenero M.J. et al. Intrauterine candidiasis: report of four cases. Arch Gynecol Obstet 2008; 24 (4): 77-79.
  64. Playford E.G., Sorrell T.C. Optimizing therapy for Candida infections. Semin Respir Crit Care Med 2007; 28 (6): 678-688.
  65. Khosravi A.R., Eslami A.R., Shokri H., Kashanian M. Zataria multiflora cream for the treatment of acute vaginal candidiasis. Int J Gynaecol Obstet 2008; 7 (5): 75-80.
  66. Sobel J.D. Vulvovaginitis - when Candida becomes a problem. Dermatol Clin 1998; 16 (1): 763-768.
  67. Murav'eva V.V. Mikrobiologicheskaya diagnostika bakterial'nogo vaginoza u zhenshchin reproduktivnogo vozrasta: Dis. ... kand. med. nauk. M 1997.
  68. Eschenbach D.A. Bacterial vaginosis: emphasis on upper genital tract complications. Obstet Ginecol Clin North Am 1989; 16: 53-610.
  69. Eschenbach D.A. Hystoty and review of bacterial vaginosis. Am J Obstet Gynecol 1993; 169 (2): 441-445.
  70. Verhelst R., Verstraelen H., Claeys G. et al. Cloning of 16S rRNA genes amplified from normal and disturbed vaginal microflora suggests a strong association between Atopobium vaginae, Gardnerella vaginalis and bacterial vaginosis. BMC Microbiol 2004; 4: 16.
  71. Fredericks D.N., Fiedler T.L., Marrazzo J.M. Molecular Identification of Bacteria Associated with Bacterial Vaginosis. N Engl J Med 2005; 353: 1899-1911.
  72. Trama J.P., Pascal K.E., Zimmerman J., Self M.J. et al. Rapid detection of Atopobium vaginae and association with organisms implicated in bacterial vaginosis. Mol Cell Probes 2008; 22 (2): 96-102.
  73. Menard J.P., Fenollar F., Henry M. et al. Molecular Quantification of Gardnerella vaginalis and Atopobium vaginae Loads to Predict Bacterial Vaginosis. Clin Infect Dis 2008; 47: 33-43.
  74. Ferris M.J., Masztal A., Martin D.H. Use of species-directed 16S rRNA gene PCR primers for detection of Atopobium vaginae in patients with bacterial vaginosis. J Clin Microbiol 2004; 42 (12): 5892-5894.
  75. Backer E., Verhelst R., Verstraelen H. et al. Antibiotic susceptibility of Atopobium vaginae. BMC Infect Dis 2006; 6: 51.
  76. Polatti F. Bacterial vaginosis, Atopobium vaginae and nifuratel. Curr Clin Pharmacol 2012; 7 (1): 36-40.
  77. Shipulina O.Yu., Romanyuk T.N., Skachkova T.S., Safonova A.P., Gushchin A.E. Razrabotka i validatsiya test-sistem semeistva Florotsenoz dlya diagnostiki sostoyaniya mikrobiotsenoza vlagalishcha. Molekulyarnaya diagnostika-2010. Materialy konf. t. III, s. 292-298.
  78. Centers for Disease Control: Sexually transmitted diseases. MMWR. 1998; 28 (4): 61-63.
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