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Titov I.S.

Moscow Scientific and Practical Center of Dermatovenereology and Cosmetology

Frigo N.V.

Moscow Scientific and Practical Center of Dermatovenereology and Cosmetology;
State Research Center — Burnasyan Federal Medical Biophysical Center of Federal Medical Biological Agency

Gushchin A.E.

Moscow Research and Practical Center for Dermatovenereology and Cosmetology of the Moscow Healthcare Department

Chernova N.I.

Moscow Scientific and Practical Center of Dermatovenereology and Cosmetology

Zhukova O.V.

Moscow Scientific and Practical Center of Dermatovenereology and Cosmetology;
Patrice Lumumba Peoples’ Friendship University of Russia

Arseenkova O.Yu.

Semashko National Research Institute of Public Health

Evaluation of the results of treatment of anogenital (venereal) warts of the anorectal region with combined methods

Authors:

Titov I.S., Frigo N.V., Gushchin A.E., Chernova N.I., Zhukova O.V., Arseenkova O.Yu.

More about the authors

Journal: Russian Journal of Clinical Dermatology and Venereology. 2025;24(6): 798‑806

DOI: 10.17116/klinderma202524061798

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Table of contents

EVALUATION OF THE RESULTS OF TREATMENT OF ANOGENITAL (VENEREAL) WARTS OF THE ANORECTAL REGION WITH COMBINED METHODS
EVALUATION OF THE RESULTS OF TREATMENT OF ANOGENITAL (VENEREAL) WARTS OF THE ANORECTAL REGION WITH COMBINED METHODS

To cite this article:

Titov IS, Frigo NV, Gushchin AE, Chernova NI, Zhukova OV, Arseenkova OYu. Evaluation of the results of treatment of anogenital (venereal) warts of the anorectal region with combined methods. Russian Journal of Clinical Dermatology and Venereology. 2025;24(6):798‑806. (In Russ.)
https://doi.org/10.17116/klinderma202524061798

Подписка 2026 Клиническая дерматология и венерология (Russian Journal of Clinical Dermatology and Venereology)
МСФ на ЯМ
Использование инфографики авторами научных работ
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Abstract:

BACKGROUND

Anogenital papillomavirus infection is a common sexually transmitted viral infection. Typically, infection occurs in the anorectal region with severe clinical manifestations and has a tendency to recurrence, which can worsen treatment results.

OBJECTIVE

To study the results of combined treatment of patients with anogenital (venereal) warts of anorectal localization using a polysaccharide drug from Solanum tuberosum shoots in different pharmaceutical forms and to compare its efficacy with a recombinant interferon alpha-2b drug.

MATERIAL AND METHODS

The study included 141 patients. All subjects underwent a comprehensive examination for sexually transmitted infection. The study participants were divided into 5 clinical groups, in which course therapy with drug from Solanum tuberos shoots and recombinant interferon alpha-2b in various pharmaceutical forms were administered. Destruction of formations was done in presence of drug application. The results were evaluated every 14 days.

RESULTS

The efficacy of the course therapy with shoots of Solanum tuberosum plant was 100% in intravenous injection during the follow-up period of 3 months, 89% in rectal suppository use and 70% in gel application in HIV-positive patients. The efficacy of rectal suppositories of recombinant interferon alpha-2b in non-HIV patients amounted to 74% and only 60% in HIV-infected patients.

CONCLUSION

The combined treatment results of patients with anogenital warts of anorectal localization using a drug based on polysaccharides from Solanum tuberosum shoots in various pharmaceutical forms (solution for intravenous injection, rectal suppositories, gel for topical and external use) have shown their high clinical efficacy, which appeared to be higher than for the similar pharmaceutical form of recombinant interferon alpha-2b in non-HIV-infected patients in parenteral intravenous use.

Keywords:

anogenital warts
treatment
polysaccharides of Solanum tuberosum shoots
recombinant interferon alpha-2b

Authors:

Titov I.S.

Moscow Scientific and Practical Center of Dermatovenereology and Cosmetology

Frigo N.V.

Moscow Scientific and Practical Center of Dermatovenereology and Cosmetology;
State Research Center — Burnasyan Federal Medical Biophysical Center of Federal Medical Biological Agency

Gushchin A.E.

Moscow Research and Practical Center for Dermatovenereology and Cosmetology of the Moscow Healthcare Department

Chernova N.I.

Moscow Scientific and Practical Center of Dermatovenereology and Cosmetology

Zhukova O.V.

Moscow Scientific and Practical Center of Dermatovenereology and Cosmetology;
Patrice Lumumba Peoples’ Friendship University of Russia

Arseenkova O.Yu.

Semashko National Research Institute of Public Health

Received:

21.10.2025

Accepted:

04.11.2025

Close metadata

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