Epidemiological and socio-behavioral risk factors associated with transmission of lymphogranuloma venereum

Titov I.S.; Gushchin A.E.; Frigo N.V.; Dolya O.V.; Zhukova O.V.

doi:https://doi.org/10.17116/klinderma202524061742

Titov I.S.

Moscow Scientific and Practical Center of Dermatovenereology and Cosmetology

ORCID: 0000-0002-5952-8809

Gushchin A.E.

Moscow Scientific and Practical Center of Dermatovenerology and Cosmetology

ORCID: 0000-0002-0399-1167

Frigo N.V.

Moscow Scientific and Practical Center of Dermatovenereology and Cosmetology;
State Research Center — Burnasyan Federal Medical Biophysical Center of Federal Medical Biological Agency

ORCID: 0000-0001-6231-971X

Dolya O.V.

Moscow Scientific and Practical Center of Dermatovenerology and Cosmetology;
Peoples’ Friendship University of Russia

ORCID: 0000-0001-5019-4593

Zhukova O.V.

Moscow Scientific and Practical Center of Dermatovenereology and Cosmetology;
Patrice Lumumba Peoples’ Friendship University of Russia

SPIN RSCI: 8584-7564
Scopus AuthorID: 57211220271
ORCID: 0000-0001-5723-6573

Epidemiological and socio-behavioral risk factors associated with transmission of lymphogranuloma venereum

Authors:

Titov I.S., Gushchin A.E., Frigo N.V., Dolya O.V., Zhukova O.V.

More about the authors

Journal: Russian Journal of Clinical Dermatology and Venereology. 2025;24(6): 742‑748

DOI: 10.17116/klinderma202524061742

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To cite this article:

Titov IS, Gushchin AE, Frigo NV, Dolya OV, Zhukova OV. Epidemiological and socio-behavioral risk factors associated with transmission of lymphogranuloma venereum. Russian Journal of Clinical Dermatology and Venereology. 2025;24(6):742‑748. (In Russ.)
https://doi.org/10.17116/klinderma202524061742

Подписка 2026 Клиническая дерматология и венерология (Russian Journal of Clinical Dermatology and Venereology)

Использование инфографики авторами научных работ

BACKGROUND

Lymphogranuloma venereum (LGV) is a sexually transmitted infection (STI), which is caused by L1-L3 serovars of Chlamydia trachomatis (C. trachomatis-LGV). Clinically, LGV often manifests behind the mask of proctocolitis related to inflammatory bowel diseases, and men who have sex with men (MSM) are susceptible to infection. Cases of LGV in the Moscow region have been registered since 2018. Timely molecular diagnosis of LGV can reduce the incidence of such socially significant diseases as HIV, syphilis and hepatitis C among MSM, and assessment of patients’ behavioral risks in the history taking allows to suspect this diagnosis in men referring with specific clinical manifestations to coloproctologists, gastroenterologists or dermatovenereologists.

OBJECTIVE

To assess the prevalence of infection caused by L1-L3 and D-K serovars of C. trachomatis among MSM in the Moscow region, to study comparatively the socio-behavioral features of patients.

MATERIAL AND METHODS

During this study, 855 men, residents of Moscow, with inflammatory diseases of the rectum and anal canal, who visited coloproctologist were screened. Patients underwent: proctological examination, testing for the presence of STIs causative agents’ DNA with a real-time polymerase chain reaction, serological assay for HIV, syphilis and viral hepatitis. Socio-behavioral characteristics were evaluated according to the data obtained from the questionnaire.

RESULTS

LGV has been revealed in 279 persons, urogenital chlamydia infection of anorectal localization — in 92 persons. All patients with LGV belonged to MSM, significantly more often had group sex compared to the patients with urogenital chlamydia infection, had more than 5 partners in 6 months before health encounter, history of syphilis as well as were HIV-infected.

CONCLUSION

The prevalence of infection caused by L1-L3 and D-K serovars of C. trachomatis has been evaluated among MSM in the Moscow region, socio-behavioral features of patients seeking coloproctological care have been studied comparatively.

Keywords:

lymphogranuloma venereum

C.trachomatis

proctitis

inflammatory bowel diseases

STIs

Authors:

Titov I.S.

Moscow Scientific and Practical Center of Dermatovenereology and Cosmetology

ORCID: 0000-0002-5952-8809

Gushchin A.E.

Moscow Scientific and Practical Center of Dermatovenerology and Cosmetology

ORCID: 0000-0002-0399-1167

Frigo N.V.

Moscow Scientific and Practical Center of Dermatovenereology and Cosmetology;
State Research Center — Burnasyan Federal Medical Biophysical Center of Federal Medical Biological Agency

ORCID: 0000-0001-6231-971X

Dolya O.V.

Moscow Scientific and Practical Center of Dermatovenerology and Cosmetology;
Peoples’ Friendship University of Russia

ORCID: 0000-0001-5019-4593

Zhukova O.V.

Moscow Scientific and Practical Center of Dermatovenereology and Cosmetology;
Patrice Lumumba Peoples’ Friendship University of Russia

SPIN RSCI: 8584-7564
Scopus AuthorID: 57211220271
ORCID: 0000-0001-5723-6573

Received:

02.04.2025

Accepted:

27.09.2025

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References:

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