Descriptive epidemiological study of the morbidity with hereditary non-syndromic disorders of keratinization among the population of Moscow

Zavarina I.V.; Berezovskaya E.M.; Potekaev N.N.; Zhukova O.V.

doi:https://doi.org/10.17116/klinderma202524061750

Zavarina I.V.

Moscow Scientific and Practical Center of Dermatovenereology and Cosmetology

ORCID: 0009-0000-8954-7421

Berezovskaya E.M.

Moscow Scientific and Practical Center of Dermatovenereology and Cosmetology

ORCID: 0000-0001-6668-5186

Potekaev N.N.

Moscow Scientific and Practical Center of Dermatovenerology and Cosmetology;
The Russian National Research Medical University named after N.I. Pirogov

SPIN RSCI: 8862-5688
Scopus AuthorID: 56437430600
ORCID: 0000-0002-9578-5490

Zhukova O.V.

Moscow Scientific and Practical Center of Dermatovenereology and Cosmetology;
Patrice Lumumba Peoples’ Friendship University of Russia

SPIN RSCI: 8584-7564
Scopus AuthorID: 57211220271
ORCID: 0000-0001-5723-6573

Descriptive epidemiological study of the morbidity with hereditary non-syndromic disorders of keratinization among the population of Moscow

Authors:

Zavarina I.V., Berezovskaya E.M., Potekaev N.N., Zhukova O.V.

More about the authors

Journal: Russian Journal of Clinical Dermatology and Venereology. 2025;24(6): 750‑759

DOI: 10.17116/klinderma202524061750

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To cite this article:

Zavarina IV, Berezovskaya EM, Potekaev NN, Zhukova OV. Descriptive epidemiological study of the morbidity with hereditary non-syndromic disorders of keratinization among the population of Moscow. Russian Journal of Clinical Dermatology and Venereology. 2025;24(6):750‑759. (In Russ.)
https://doi.org/10.17116/klinderma202524061750

Подписка 2026 Клиническая дерматология и венерология (Russian Journal of Clinical Dermatology and Venereology)

Использование инфографики авторами научных работ

BACKGROUND

The study of tendencies in the incidence and prevalence of hereditary skin diseases, including those manifested by keratinization disorders, is of fundamental importance in practical medicine — epidemiological studies serve as a basis for the organization of medical care. Clarification of the structure of morbidity helps to plan drug provision, diagnosis and optimal health and social care for patients, rehabilitation, sanatorium-resort treatment.

OBJECTIVE

Comparative analysis of the prevalence and incidence of non-syndromic disorders of keratinization among children and adults in Moscow.

MATERIAL AND METHODS

Evaluation of epidemiological data on the incidence and morbidity of this nosological group was carried out for the 2017—2023 period based on a retrospective analysis of the medical records of patients who underwent outpatient treatment and follow-up at the MSPCDC (Moscow Scientific and Practical Center of Dermatovenereology and Cosmetology). Data from the MSPCDC formed from the information presented in the Form of Federal Statistical Monitoring No. 12 (“Information on the number of diseases recorded in patients living in the service area of a health facility”) were used to study morbidity in the Russian Federation and Moscow as sources of information.

RESULTS AND CONCLUSION

An analysis of the overall incidence has shown that there is a clear tendency to increase in the number of cases of reported diseases, such as congenital ichthyosis (ICD-10 — Q80) and other specified congenital malformations of skin (Q82.8). The prevalence growth for the 2017—2023 period was 4.76 times and correlates with the increase in the incidence. The incidence of congenital ichthyosis in the Russian Federation has been decreased by 16.0% during the same period and increased by 4.76 times in Moscow. At the same time, the prevalence in the Russian Federation has been increased by 7.15%, in Moscow — by 2.44 times.

Keywords:

prevalence

incidence

ichthyosis

ichthyosiform erythroderma

palmoplantar keratoderma

Darier’s disease

Authors:

Zavarina I.V.

Moscow Scientific and Practical Center of Dermatovenereology and Cosmetology

ORCID: 0009-0000-8954-7421

Berezovskaya E.M.

Moscow Scientific and Practical Center of Dermatovenereology and Cosmetology

ORCID: 0000-0001-6668-5186

Potekaev N.N.

Moscow Scientific and Practical Center of Dermatovenerology and Cosmetology;
The Russian National Research Medical University named after N.I. Pirogov

SPIN RSCI: 8862-5688
Scopus AuthorID: 56437430600
ORCID: 0000-0002-9578-5490

Zhukova O.V.

Moscow Scientific and Practical Center of Dermatovenereology and Cosmetology;
Patrice Lumumba Peoples’ Friendship University of Russia

SPIN RSCI: 8584-7564
Scopus AuthorID: 57211220271
ORCID: 0000-0001-5723-6573

Received:

28.08.2025

Accepted:

19.11.2025

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References:

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