Endothelium functional activity in different morphotypes of facial skin aging

Kulchitskaya DB, Fesyun AD, Yusova ZhYu, et al. Endothelium functional activity in different morphotypes of facial skin aging. Russian Journal of Clinical Dermatology and Venereology. 2022;21(2):238‑241. (In Russ.)
https://doi.org/10.17116/klinderma202221021238

Подписка 2026 Клиническая дерматология и венерология (Russian Journal of Clinical Dermatology and Venereology)

Использование инфографики авторами научных работ

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BACKGROUND

Age-related changes in facial skin are an urgent problem in modern dermatology and cosmetology. It has been established that an important role in the skin aging pathogenesis is played by microcirculatory disorders, which are often expressed in a decrease in the number and size of dermal vessels, as well as in disturbance of vascular tone. Objective detection of microcirculatory disorders helps to tailor drug and non-drug therapies and evaluate their effectiveness.

OBJECTIVE

To study the microcirculation and endothelial function state in females with age-related facial skin changes depending on aging morphotypes.

MATERIAL AND METHODS

The study included 136 females aged 36 to 57 years with signs of age-related facial skin changes. Facial skin morphotypes were determined according to I.I. Kolgunenko classification. The microcirculation state was assessed by laser Doppler flowmetry using LAKK-02 device.

RESULTS

Heterogeneous changes in the microcirculatory state were observed in females with mixed morphotype. Spastic and hyperemic types of microcirculation were detected in these subjects, whereas in those with deformational and rugulose morphotypes, microcirculatory disorders were mainly of the hypertonic type. Endothelial dysfunction was observed in all morphotypes.

CONCLUSION

Patients with age-related skin changes were found to have endothelial dysfunction and abnormalities in the microcirculatory system. These changes varied in different skin morphotypes, so elimination of microcirculatory disturbances and endothelial dysfunction makes it possible to successfully correct age-related skin changes.

Keywords:

age-related skin changes

microcirculation

endothelial function

Authors:

Kulchitskaya D.B.

National Medical Research Center for Rehabilitation and Balneology

ORCID: 0000-0002-7785-9767

Fesyun A.D.

National Medical Research Centre for Rehabilitation and Balneology

ORCID: 0000-0003-3097-8889

Yusova Zh.Yu.

Central state medical academy of department of presidential affairs

ORCID: 0000-0001-6452-2914

Kruglova L.S.

Central State Medical Academy of Department of Presidential Affairs

Scopus AuthorID: 24168854300
ORCID: 0000-0002-5044-5265

Demidion D.V.

Central State Medical Academy of Department of Presidential Affairs

ORCID: 0000-0002-5901-4250

Baranova E.L.

Central State Medical Academy of Department of Presidential Affairs

ORCID: 0000-0002-6807-3850

Akhmedbaeva I.A.

Central State Medical Academy of Department of Presidential Affairs

Gushchina N.V.

National Medical Research Center for Rehabilitation and Balneology

Received:

13.04.2021

Accepted:

19.01.2022

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References:

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