The high prevalence of acne all over the world and in Russia, including its influence on the patients’ quality of life, the role of numerous environmental factors, dietary habits and lifestyle on the disease determine the relevance of increasing the effectiveness of its treatment and the continuous search for affordable and convenient medicines safe in use.

OBJECTIVE

To demonstrate the high efficacy and safety of solution containing 0.025% isotretinoin in alcohol-glycol base in patients with papulopustular acne.

MATERIAL AND METHODS

The study included 88 patients with papulopustular acne at the age from 18 to 47 years. In group 1 (n 48), patients were prescribed topically a drug containing 0.025% isotretinoin 1—2 times a day for 4—6 weeks. Patients of the 2^nd group (n=40) received external therapy with a cream containing 0.1% adapalene up to 12 weeks according to medical direction to use.

RESULTS

After 12 weeks, the number of papules and pustules in patients of 1^st group became less than in patients of 2d group (p<0.001), and a significant difference relative to the initial value was observed at each observation point (p<0.001) throughout the treatment. When assessing the global therapeutic effect (GTE), reliable positive results were obtained: already on the 30^th day of treatment in the 1^st group half of the patients noted a good efficacy of the drug — 2.1 points, and after 90 days, almost all rated the therapeutic efficacy at 2.9 points against 1.9 and 2.1 points in the 2^nd group.