Effectiveness of various therapy methods for microbial eczema in children

Korotkiy V.N.; Andrienko O.N.; Burchik K.A.; Shemshuk M.I.; Rumyantsev A.G.; Potekaev N.N.

doi:https://doi.org/10.17116/klinderma202120032151

Korotkiy V.N.

Russian National Research Medical University named after N.I. Pirogov

Andrienko O.N.

Russian Children’s Clinical Hospital

Burchik K.A.

Pirogov Russian National Research Medical University

Shemshuk M.I.

Pirogov Russian National Research Medical University

Rumyantsev A.G.

Dmitry Rogachev National Medical Research Center of Pediatric Hematology, Oncology, and Immunology

Potekaev N.N.

Moscow Scientific and Practical Center of Dermatovenerology and Cosmetology;
The Russian National Research Medical University named after N.I. Pirogov

ORCID: 0000-0002-9578-5490

Effectiveness of various therapy methods for microbial eczema in children

Authors:

Korotkiy V.N., Andrienko O.N., Burchik K.A., Shemshuk M.I., Rumyantsev A.G., Potekaev N.N.

More about the authors

Journal: Russian Journal of Clinical Dermatology and Venereology. 2021;20(3‑2): 151‑156

DOI: 10.17116/klinderma202120032151

Read: 1558 times

Download PDF (RU)

Contact the author

Table of contents

To cite this article:

Korotkiy VN, Andrienko ON, Burchik KA, Shemshuk MI, Rumyantsev AG, Potekaev NN. Effectiveness of various therapy methods for microbial eczema in children. Russian Journal of Clinical Dermatology and Venereology. 2021;20(3‑2):151‑156. (In Russ.)
https://doi.org/10.17116/klinderma202120032151

Подписка 2026 Клиническая дерматология и венерология (Russian Journal of Clinical Dermatology and Venereology)

Использование инфографики авторами научных работ

Close metadata

OBJECTIVE

Effectiveness evaluation of various ME therapy methods in children.

MATERIAL AND METHODS

The study included 108 patients aged 1 to 13 years (median age 7 years) divided into 3 groups. Group 1 included 20 patients aged 1 to 13 years (median age 8 years) who received external therapy with a combined drug (topical steroid + antibiotic + antimycotic; pimafucort) in combination with a 1st generation antihistamine (suprastin at an age-specific dose) + sedative (antipruritic) agent for 14 days. Group 2 consisted of 49 patients aged 1 to 13 years (median age 6 years) who received therapy similar to that in group 1 in combination with laser therapy (5 sessions). Group 3 included 39 children aged 2 to 13 years (median age 7 years) who received therapy similar to patients in group 1 in combination with treatment of lesions with CAP (5 sessions). The severity of ME was assessed using the ME severity index, the efficacy was assessed by clinical criteria. The efficacy assessment also includes an analysis of the number of relapses during the next one-year follow-up.

RESULTS

The intensity of itching decreased by 50% or more in group 1 by the 6th day, in group 2 by the 4th day, in group 3 by the 2nd day of therapy; complete relief of itching was achieved by 10th, 7th and 3rd days depending on therapy accordingly. In group 1 the complete relief of ME was achieved only in 5% of patients, significant improvement — in 30%, in group 2 — in 6 and 51%, respectively, in group 3 — in 67% and 33% of children. On average, 2.5 months passed before the next recurrence of ME in group 1, 4.5 months in group 2, and 8 months in group 3. The average length of hospitalization for a patient with moderate/severe ME was 14.6, 10.2, and 6.2 days, respectively.

CONCLUSION

The inclusion of CAP into ME therapy in children and adolescents made it possible to lengthen the period of remission by 3.2 times.

Keywords:

microbial eczema

treatment

cold atmospheric plasma

children

Authors:

Korotkiy V.N.

Russian National Research Medical University named after N.I. Pirogov

Andrienko O.N.

Russian Children’s Clinical Hospital

Burchik K.A.

Pirogov Russian National Research Medical University

Shemshuk M.I.

Pirogov Russian National Research Medical University

Rumyantsev A.G.

Dmitry Rogachev National Medical Research Center of Pediatric Hematology, Oncology, and Immunology

Potekaev N.N.

Moscow Scientific and Practical Center of Dermatovenerology and Cosmetology;
The Russian National Research Medical University named after N.I. Pirogov

ORCID: 0000-0002-9578-5490

Received:

20.02.2021

Accepted:

22.03.2021

Close metadata

References:

Rodionov AN. Dermatovenereology. The full Guide for doctors. SPb: Nauka i tekhnika; 2012. (In Russ.).
Yamany T, Schwartz RA. Infectious eczematoid dermatitis: a comprehensive review. JEADV. 2015;29(2):203-208. https://doi.org/10.1111/jdv.12715
Nikonova IV, Orlov EV, Konnov PE. Condition of biocenosis skin at microbial eczema. Prakticheskaya meditsina. 2011;49(2):81-83. (In Russ.).
Kim JW, Ko HC, Kim MB, Kim JM, Kim BS. Features of Staphylococcous aureus colonization in patients with nummular eczema. Br J Dermatol. 2013; 168(3):658-660.
Lysenko OV, Ziganshin OR, Lukyanchikova LV. Immunological criteria of microbial eczema diagnosis. Russian Journal of Clinical Dermatology and Venereology = Klinichaskaya dermatologiya i venerologiya. 2015;6:50-55. (In Russ.). https://doi.org/10.17116/klinderma201514650-55
Silina LV, Shvarts NE. Skin microbiome in case of microbial eczema. Russian Russian Journal of Clinical Dermatology and Venereology = Klinichaskaya dermatologiya i venerologiya. 2019;18(1):49-54. (In Russ.). https://doi.org/10.17116/klinderma20191801149
Sokolova TV, Malyarchuk AP, Safonova LA. The strategy of selecting topical therapy for microbial eczema. Russian Journal of Clinical Dermatology and Venereology = Klinichaskaya dermatologiya i venerologiya. 2017;16(3):46-63. (In Russ.). https://doi.org/10.17116/klinderma201716346-63
Okhlopkov VA, Pravdina OV, Zubareva EYu. State clinical guidelines for eczema management. 5th edn. M. 2015. (In Russ.). https://www.cnikvi.ru/docs/clinic_recs/bolezni-kozhi-i-pridatkov-kozhi
Reztsova PA, Raznatovskiy KI, Vashkevich AA, Kotrekhova LP, Elishakova LI, Bukiya MT. Phototherapy efficacy evaluation for the patients’ treatment with microbial eczema. Russian Journal of Clinical Dermatology and Venereology = Klinichaskaya dermatologiya i venerologiya. 2020;19(5):655-660. (In Russ.). https://doi.org/10.17116/klinderma202019051655
Korotkiy VN. The use of low-temperature atmospheric plasma in dermatology. Russian Journal of Clinical Dermatology and Venereology = Klinichaskaya dermatologiya i venerologiya. 2017;16(5): 4-11. (In Russ.). https://doi.org/10.17116/klinderma20171654-10
Isbary G, Morfill G, Schmidt HU, Georgi M, Ramrath K, Heinlin J, Karrer S, Landthaler M, Shimizu T, Steffes B, Bunk W, Monetti R, Zimmermann JL, Pompl R, Stolz W. A first prospective randomized controlled trial to decrease bacterial load using cold atmospheric argon plasma on chronic wounds in patients. Br J Dermatol. 2010;163:78-82.
Isbary G, Heinlin J, Shimizu T, Zimmermann JL, Morfill G, Schmidt H-U, Monetti R, Steffes B, Bunk W, Li Y, Klaempfl T, Karrer S, Landthaler M, Stolz W. Successful and safe use of 2 min cold atmospheric argon plasma in chronic wounds: results of a randomized controlled trial. Br J Dermatol (BJD). 2012;167(2):404-410.
Mohd Nasir N, Lee BK, Yap SS, Thong KL, Yap SL. Cold plasma inactivation of chronic wound bacteria. Arch Biochem Biophys. 2016;605:76-85.
Akimoto Y, Ikehara S, Yamaguchi T, Kim J, Kawakami H, Shimizu N, Hori M, Sakakita H, Ikehara Y. Galectin expression in healing wounded skin treated with low-temperature plasma: Comparison with treatment by electronical coagulation. Arch Biochem Biophys. 2016;605:86-94. https://doi.org/10.1016/j.abb.2016.01.012
Sokolova TV, Grigoryan SA. Index for assessing the severity of microbial eczema. Sovremennye problemy dermatovenerologii, immunologii i vrachebnoj kosmetologii. 2006;5(1):88-89. (In Russ.). https://doi.org/10.17116/klinderma20201901164
Adaskevich VP. Diagnosticheskie indeksy v dermatologii. M. 2014. (In Russ.).
Nadyrchenko NA, Khismatullina ZR, Nadyrchenko RM, Mustafina GR, Gareev EM. Indeks otsenki tyazhesti mikrobnoj ekzemy v otsenke klinicheskoj effektivnosti terapii nummulyarnoj mikrobnoj ekzemy. Ufa; 2017. (In Russ.).