Analysis of the activities of offices and branches offering paid medical services in the unstable epidemiological situation in respect to sexually transmitted infections (STIs), as well as urogenital diseases caused by opportunistic pathogenic microorganisms (OPM) and fungi, is relevant. Objective — analysis of the activities of the offices/branches offering paid medical services for the identification of STIs, urogenital diseases caused by OPMs and fungi, as well as on the number of visits of general public to the offices/branches offering paid medical services. Material and methods. Information on the activities of offices/branches offering paid medical services in Moscow State Budgetary Institution of Health «Moscow Scientific and Practical Center for Dermatovenereology and Cosmetology of the Moscow Department of Health» for the period 2012—2017, forms of federal statistical observation No. 9 for Moscow for the period 2012—2017 Statistical and analytical methods were employed. Results. The analysis of the activities of offices/branches offering paid medical services demonstrates an increase in the detection of cases of syphilis against the background of a decrease in other STIs, which indicates an unfavorable situation for this infection in the general population. The increase in the incidence of syphilis coincides with an increase in the number of visits of children of the older age group and an overall decrease in visits to the offices/branches offering paid medical services in general. Conclusion. The results of the analysis identified the need to study visits, considering the place of residence and the age of patients in order to identify risk groups for STIs and to take organizational decisions.