Pharmacotherapy of acne: an overview of current therapies

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The review summarized and systematized the available international data on the pharmacotherapy of acne and recommendations on patient surveillance.

Keywords:

acne

pathophysiologic mechanisms

clinical manifestations

recurrent acne

recommendations on pharmacotherapy

Authors:

Tuati H.

Peoples’ Friendship University of Russia, Moscow, Russia, 117198

Tishchenko A.L.

Rossiĭskiĭ universitet druzhby narodov, Moskva

Gorskiĭ V.S.

GUZ Tul'skiĭ oblastnoĭ kozhno-venerologicheskiĭ dispanser

List of references:

Nast A, Dreno B, Bettoli V. European Evidence-based (S3) Guidelines for the Treatment of Acne. JEADV 2012;26(Suppl. 1):1-29.
Kungurov NV, Zil’berberg NV, Tolstaja AI, Kohan MM. Pathogenetic basis and clinical efficiency of combined therapy of patients with acne and post-acne. Lech vrach. 2013;(10):24-28 (In Russ.)
Magin P, Adams J, Heading G, Pond D. ‘Perfect skin’, the media and patients with skin disease: a qualitative study of patients with acne, psoriasis and atopic eczema. Aust J Prim Health. 2011;17:181-185.
Rivera AE. Acne scarring: a review and current treatment modalities. J Am Acad Dermatol. 2008;59(4):659-676.
Beylot C, Auffret N, Poli E, Claudel J-P, Leccia MT. Propionobacterium acnes: an update on its role in the pathogenesis of acne. JEADV. 2014;28:271-278.
Aravijskaja ER, Sokolovskij EV. Systemic antibiotic therapy of acne: some controversial issues. Vestn dermatol venerol. 2013;(6):117-121 (In Russ.)
Rottboel L, de Foenss S, Thomsen K, Christiansen H, Andersen SM. Exploring valrubicin’s effect on Propionobacterium acnes-induced skin inflammation in vitro and in vivo. Dermatol Rep. 2015;7:6246.
Suh DH, Kwon HH. What’s new in the physiopathology of acne. Br J Dermatol. 2015;172(Suppl. 1):13-19.
Khayef G, Young J, Burns-Whitmore B, Spalding T. Effects of fish oil supplementation on inflammatory acne. Lipids in health and disease. 2012;11:165.
Lai JJ, Chang P, Lai KP, Chen L, Chang C. The role of androgen and androgen receptor in the skin-related disorders. Arch Dermatol Res. 2012;304:499-510.
Titus S, Hodge J. Diagnosis and treatment of acne. Am Fam Physician. 2012;86(8):734-740.
Thiboutot D, Dreno B, Gollnick H. A call to limit antibiotic use in acne. J Drugs Dermatol. 2013;12:1331-1332.
Perlamutrov YuN, Chizhova SK, Korchevaja TA, Ol’hovskaja KB. Comparative efficacy and tolerability of different methods of acne treatment in women. Klinicheskaya dermatologiya i venerologiya. 2012;(3): 72-77. (In Russ.)
Aravijskaja ER, Sokolovskij EV. A combination of drugs in the external treatment of acne: current data. Vestn dermatol venerol. 2012;(3):111-114. (In Russ.)
Lakshmi C. Hormone therapy in acne. Indian J Dermatol Venereol Leprol. 2013;79:322-337.
Hussein-El Ahmed H. Management of acne vulgaris with hormonal therapies in adult female patients. Dermatol Ther. 2015;28(3):166-172.
Brynhildsen J. Combined hormonal contraceptives: prescribing patterns, compliance, and benefits versus risks. Ther Adv Drug Saf. 2014;5:201-213.
Lam C, Zaenglein AL. Contraceptive use in acne. Clin Dermatol. 2014;32:502-515.
Kim GK, Del Rosso JQ. Oral spironolactone in post-teenage female patients with acne vulgaris: practical considerations for the clinical-based on current data and clinical experience. J Clin Aesthet Dermatol. 2012;5:37-50.
Hagag P, Steinschneider M, Weiss M. Role of the combination spironolactone-norgestimate-estrogen in hirsute woman with polycystic ovary syndrome. J Reprod Med. 2014;59:455-463.
Plovanich M, Weng QY, Mostaghimi A. Low usefulness of potassium monitoring among healthy young woman taking spironolactone for acne. JAMA Dermatol. 2015;151:941-944.
Leelaphiwat S, Jongwutiwes T, Lertvikool S, Tabcharoen C, Sukprasert M. Comparison of desogestrel/ethinylestradiol plus spironolactone versus cyproterone acetate/ethinylestradiol in the treatment of polycystic ovary syndrome: a randomized controlled trial. J Obstet Gynaecol Res. 2015;41:401-410.
Saint-Jean M, Ballanger F, Nguyen JM, Khammari A, Dreno B. Importance of spironolactone in the treatment of acne in adult woman. J Eur Acad Dermatol Venereol. 2011;25:1480-1481.
Arowojolu AO, Gallo MF, Lopez LM, Grimez DA. Combined oral contraceptive pills for treatment of acne. Cochrane Database Syst Rev. 2012;7:CD004425.
Adalatkhah H, Pourfarzi F, Sadeghi-Bazargani H. Flutamide versus a cyproterone acetate-ethynil estradiol combination in moderate acne: a pilot randomized clinical trial. Clin Cosmet Investig Dermatol. 2011;4:117-121.
Friedman. Spironolactone for adult female acne. Cutis. 2015;96:216-217.
Zaenglein AL, Pathy AL, Schlosser BJ. Guidelines of care for the management of acne vulgaris. J Am Acad Dermatol. 2016;74(5):945-973.
Bettoli V, Zauli S, Virgili A. Is hormonal treatment still an option in acne today? Br J Dermatol. 2015;172(Suppl. 1):37-46.
Del Rosso JQ, Harper JC, Graber EM, Thiboutot D, Silverberg NB. Status report from the American Acne&Rosacea Society on medical management of acne in adult woman, part1: overview, clinical characteristics, and laboratory evaluation. Cutis. 2015;96:236-241.
Gollnick HP, Bettoli V, Lambert J, Araviiskaia E, Binic I. A consensus-based practical and daily guide for the treatment of acne patients. J Eur Acad Dermatol Venereol. 2016;30:1480-1490.
Nast A, Ernst H, Rosumeck S, Erdmann R, Jacobs A. Risk of complications due to anticoagulation during dermatosurgical procedures: a systematic review and metaanalysis. J Eur Acad Dermatol Venereol. 2014;28(12): 1603-1609.
Zaba R, Shwartz R, Jarmuda S, Czarnecka-Operatz M, Silny W. Acne fulminans: explosive systemic form of acne. J Eur Acad Dermatol Venerol. 2011;25:501-507.
Tago O, Nagai Y, Matsushima Y, Ishikawa O. A case of acne fulminans successfully treated with cyclosporine A and prednisolone. Acta Derm Venerol. 2011;91:337-338.
Tyler KH, Zirwas MJ. Pregnancy and dermatologic therapy. J Am Acad Dermatol. 2013;68(4):663-671.
Gollnick HP, Dreno B. Pathophysiology and management of acne. J Eur Acad Dermatol Venereol. 2015;29(Suppl. 4):1-2.
Harper JC. Use of oral contraceptives for management of acne vulgaris: practical considerations in real world practice. Dermatol Clin. 2016;34(2):159-165.
Arrington EA, Patel NS, Geranker A, Feldman SR. Combined oral contraceptives for the treatment of acne: a practical guide. Cutis. 2012;90(2):83-90.
Chularojanamontri L, Tuchinda P, Kulthanan K, Pongparit K. Moisturizers for Acne: What are their Constituents? J Clin Aesthet Dermatol. 2014;7:37-44.
Ghosh S, Chauduri S, Jain VK, Aggarwal K. Profiling and hormonal therapy for acne in woman. Indian J Dermatol. 2014;59(2):107-115.
Bubna AK. Metformin — for the dermatologist. Indian J Pharmacol. 2016;48(1):4-40.
Pugashetti R, Shinkai K. Treatment of acne vulgaris in pregnant patients. Dermatol Ther. 2013;26:302-311.
Romoren M, Lindbaek M, Nordeng H. Pregnancy outcome after gestational exposure to erythromycin-a population-based register study from Norway. Br J Clin Pharmacol. 2012;74:1053-1062.
Del Rosso JQ, Webster GF, Rosen T, Thiboutot D, Leyden JJ. Status report from the Scientific Panel on Antibiotic Use in Dermatology of the American Acne and Rosacea Society: Part 1. Antibiotic prescribing patterns, sources of antibiotic exposure, antibiotic consumption and emergence of antibiotic resistance, impact of alterations in antibiotic prescribing, and clinical sequelae of antibiotic use. J Clin Aesthet Dermatol. 2016;9:18-24.
Amichai B, Grunwald MH. Isotretinoin in dermatology. J Dermatol Treat. 2002;11:219-240.
Olisova OYu. The effectiveness of systemic retinoids for acne. RMZh. 2016;(10):602-606 (In Russ.)
Dolzhikova JeM, Sternin YuI, Shuginina EA. Pathogenetic rationale and experience of using systemic enzyme therapy in cosmetology and plastic surgery. RMZh. 2011;(11):19:698-702. (In Russ.)
Vil’son S, Tishchenko AL, Gorskii VS. Assessment of the ability of lymphocytes to activate background local injections of acidic peptidoglycan in patients with acne. Klinicheskaya dermatologiya i venerologiya. 2015;(3):14:37-39 (In Russ.)

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