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Pakhomova E.E.

St. Petersburg State University, St. Petersburg, Russia, 199034

Smirnova I.O.

Sankt-Peterburgskiĭ gosudarstvennyĭ universitet, Sankt-Peterburg, Rossiia, 199106

Molecular, biological, and clinical aspects of the use of platelet-rich plasma in the treatment of androgenetic alopecia

Authors:

Pakhomova E.E., Smirnova I.O.

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Journal: Russian Journal of Clinical Dermatology and Venereology. 2017;16(6): 16‑22

DOI: 10.17116/klinderma201716616-21

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Table of contents

MOLECULAR, BIOLOGICAL, AND CLINICAL ASPECTS OF THE USE OF PLATELET-RICH PLASMA IN THE TREATMENT OF ANDROGENETIC ALOPECIA
MOLECULAR, BIOLOGICAL, AND CLINICAL ASPECTS OF THE USE OF PLATELET-RICH PLASMA IN THE TREATMENT OF ANDROGENETIC ALOPECIA

To cite this article:

Pakhomova EE, Smirnova IO. Molecular, biological, and clinical aspects of the use of platelet-rich plasma in the treatment of androgenetic alopecia. Russian Journal of Clinical Dermatology and Venereology. 2017;16(6):16‑22. (In Russ.)
https://doi.org/10.17116/klinderma201716616-21

Подписка 2026 Клиническая дерматология и венерология (Russian Journal of Clinical Dermatology and Venereology)
МСФ на ЯМ
Использование инфографики авторами научных работ
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Abstract:

Androgenetic alopecia is one of the most common types of hair loss and it is associated with social and psychological discomfort. The available repertoire of treatment tools has a number of limitations. The development of new treatments is very important. Analysis of scientific medical literature focusing on the investigation of platelet-rich plasma effect on hair growth and clinical results confirm the validity of the use of this technique in patients with androgenetic alopecia and form the basis for the further study of therapeutic action mechanisms. The features of the functioning of hair follicles in the pathogenesis of androgenetic alopecia are described. Basic clinical and biological effects associated with the use of platelet-rich plasma, affecting hair growth, were specified. We determined limitations of the investigation and evaluation of the results of treatment with platelet-rich plasma in terms of evidence-based medicine.

Keywords:

androgenetic alopecia
treatment
platelet rich plasma
PRP-therapy

Authors:

Pakhomova E.E.

St. Petersburg State University, St. Petersburg, Russia, 199034

Smirnova I.O.

Sankt-Peterburgskiĭ gosudarstvennyĭ universitet, Sankt-Peterburg, Rossiia, 199106

Close metadata

References:

  1. Gan DC, Sinclair RD. Prevalence of male and female pattern hair loss in Maryborough. J Investig Dermatol Symp Proc. 2005;10(3):184-189.
  2. Blumeyer A, Tosti A, Messenger A et al. Evidence-based (S3) guide-line for the treatment of androgenetic alopecia in women and in men. J Dtsch Dermatol Ges. 2011 Oct;9 Suppl 6:S1-S57. https://doi.org/10.1111/j.1610-0379.2011.07802.x
  3. Semalty M, Semalty A, Joshi GP, Rawat MSM. Hair growth and rejuvenation: an overview. J Dermatol Treat 2011;22(3):123-132.
  4. Rogers NE. Hair transplantation update. Semin Cutan Med Surg. 2015 Jun;34(2):89-94. https://doi.org/10.12788/j.sder.2015.0131
  5. Chaudhari ND, Sharma YK, Dash K, Deshmukh P. Role of platelet-rich plasma in the management of androgenetic alopecia. Int J Trichology. 2012 Oct-Dec;4(4):291-292. https://doi.org/10.4103/0974-7753.111222
  6. Carter CA, Jolly DG, Worden CESr, et al. Platelet-rich plasma gel promotes differentiation and regeneration during equine wound healing. Exp Mol Pathol. 2003 Jun;74(3):244-255.
  7. Sampson S, Gerhardt M, Mandelbaum B. Platelet rich plasma injection grafts for musculoskeletal injuries: a review. Curr Rev Musculoskelet Med. 2008 Dec;1(3-4):165-174. https://doi.org/10.1007/s12178-008-9032-5
  8. Esposito M. Effectiveness of sinus lift procedures for dental implant rehabilitation: a Cochrane systematic review. Eur J Oral Implantol. 2010;3(1):7-26.
  9. Sclafani AP. Platelet-rich fibrin matrix (PRFM) for androgenetic alopecia. Facial Plast Surg. 2014;30:219-224.
  10. Arshdeep, Kumaran M.S. Platelet-rich plasma in dermatology: boon or a bane? Indian J Dermatol Venereol Leprol. 2014;80:5-14. https://doi.org/10.4103/0378-6323.125467
  11. Chaudhari ND, Sharma YK, Dash K, Deshmukh P. Role of platelet-rich plasma in the management of androgenetic alopecia. Int J Trichology. 2012 Oct-Dec;4(4):291-292. https://doi.org/10.4103/0974-7753.111222
  12. Lacci K, Dardik A Platelet-rich plasma: support for its use in wound healing. Yale J Biol Med. 2010 March;83(1):1-9.
  13. Greco J, Brandt R. The effects of autologous platelet rich plasma and various growth factors on non-transplanted miniaturized hair. Hair Transplant Forum International. 2009 March-April;49-50.
  14. Foster TE, Puskas BL, Mandelbaum BR, Gerhardt MB, Rodeo SA. Platelet-rich plasma: from basic science to clinical applications. Am J Sports Med. 2009 Nov;37(11):2259-2272. https://doi.org/10.1177/0363546509349921
  15. Uebel CO, da Silva JB, Cantarelli D, Martins P. The role of platelet plasma growth factors in male pattern baldness surgery. Plast Reconstr Surg. 2006;118:1458-1467. https://doi.org/10.1097/01.prs.0000239560.29172.33
  16. Park KY, Kim HK, Kim BJ, Kim MN. Letter: platelet-rich plasma for treating male pattern baldness. Dermatol Surg. 2012 Dec;38(12):2042-2044. https://doi.org/10.1111/dsu.12037
  17. Betsi EE, Germain E, Kalbermatten DF, et al. Platelet-rich plasma injection is effective and safe for the treatment of alopecia. Eur J Plast Surg. 2013;36:407-412.
  18. Cervelli V, Garcovich S, Bielli A, et al. The effect of autologous activated platelet rich plasma (AA-PRP) injection on pattern hair loss: clinical and histomorphometric evaluation. Biomed Res Int 2014. https://doi.org/10.1155/2014/760709
  19. Khatu SS, More YE, Gokhale NR, et al. Platelet-rich plasma in androgenic alopecia: Myth or an effective tool. J Cutan Aesthet Surg. 2014;7:107-110.
  20. Sclafani AP. Platelet-rich fibrin matrix (PRFM) for androgenetic alopecia. Facial Plast Surg. 2014;30:219-224.
  21. Gkini MA, Kouskoukis AE, Tripsianis G, et al. Study of platelet-rich plasma injections in the treatment of androgenetic alopecia through an one-year period. J Cutan Aesthet Surg. 2014;7:213-219.
  22. Gkini MA, Alexandros-Efstratios K, Dimitris R, Konstantinos K. Platelet-rich plasma as a potential treatment for noncicatricial alopecias. Int J Trichology. 2015 Apr-Jun;7(2):54-63. https://doi.org/10.4103/0974-7753.160098
  23. Yip L, Rufaut N, Sinclair R. Role of genetics and sex steroid hormones in male androgenetic alopecia and female pattern hair loss: an update of what we now know. Australas J Dermatol. 2011 May;52(2):81-88. https://doi.org/10.1111/j.1440-0960.2011.00745.x
  24. Kozlowska U, Blume-Peytavi U, Kodelja V, et al. Expression of vascular endothelial growth factor (VEGF) in various compartments of the human hair follicle. Arch Dermatol Res. 1998 Dec;290(12):661-668.
  25. Yano K, Brown LF, Detmar M. Control of hair growth and follicle size by VEGF-mediated angiogenesis. J Clin Invest. 2001 Feb;107(4):409-417.
  26. Li W, Enomoto M, Ukegawa M, et al. Subcutaneous injections of platelet-rich plasma into skin flaps modulated proangiogenic gene expression and improve survival rates. Plast Reconstr Surg. 2012;129(4):858-866. https://doi.org/10.1097/PRS.0b013e3182450ac9
  27. Li ZJ, Choi H-I, Choi D-K, et al. Autologous platelet-rich plasma: a potential therapeutic tool for promoting hair growth. Dermatol Surg. 2012 Jul;38(7 Pt 1):1040-1046. https://doi.org/10.1111/j.1524-4725.2012.02394.x
  28. Kwack M, Kim M, Kim J, Sung J. Dickkopf 1 promotes regression of hair follicles. J Invest Dermatol. 2012 Jun;132(6):1554-1560. https://doi.org/10.1038/jid.2012.24
  29. Sohn KC, Shi G, Jang S, et al. Pitx2, a beta-catenin-regulated transcription factor, regulates the differentiation of outer root sheath cells cultured in vitro. J Dermatol Sci. 2009 Apr;54(1):6-11. https://doi.org/10.1016/j.jdermsci.2008.11.006
  30. Uebel CO, da Silva JB, Cantarelli D, Martins P. The role of platelet plasma growth factors in male pattern baldness surgery. Plastic and Reconstructive Surgery. 2006;118:1458-1467. https://doi.org/10.1097/01.prs.0000239560.29172.33
  31. Takakura N, Yoshida H, Kunisada T, et al. Involvement of platelet-derived growth factor receptor-alpha in hair canal formation. J Invest Dermatol. 1996 Nov;107(5):770-777.
  32. Rinaldi F, Sorbellini E, Bezzola P. The role of up-stimulation of growth factors in hair transplantation: improve the revascularization of transplanted hair growth mediated by angiogenesis. Hair Transplant Forum Int. 2007;17(4):125-127.
  33. Dhurat R, Sukesh M. Principles and methods of preparation of platelet-rich plasma: a review and author’s perspective. J Cutan Aesthet Surg. 2014 Oct-Dec;7(4):189-197. https://doi.org/10.4103/0974-2077.150734
  34. Graziani F, Ivanovski S, Cei S, et al. The in vitro effect of different PRP concentrations on osteoblasts and fibroblasts. Clin Oral Implants Res. 2006 Apr;17(2):212-219. https://doi.org/101111/j1600-0901.2009.01203.x
  35. Kakudo N, et al. Proliferation-promoting effect of platelet-rich plasma on human adipose-derived stem cells and human dermal fibroblasts. Plast Reconstr Surg. 2008 Nov;122(5):1352-1360. https://doi.org/10.1097/PRS.0b013e3181882046
  36. Tuomi H, Best TM. The inflammatory response: friend or enemy to muscle tissue? Br J Sports Med. 2003 Aug;37(4):284-286. https://doi.org/10.1136/bjsm.37.4.284
  37. Anitua E, et al. Antibacterial effect of plasma rich in growth factors (PRGF-Endoret) against Staphylococcus aureus and Staphylococcus epidermidis strains. Clin Exp Dermatol. 2012 Aug;37(6):652-657.
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