Objective — the study is aimed at assessing methylation status of WNT-inhibitory factor 1 (WIF1) gene in benign lesions of the skin and mucous membranes caused by human papilloma virus (HPV). Material and methods. We analyzed 32 specimens of benign skin tumor bioptates obtained by means of shaving biopsies in patients aged 16 to 67 years. The study group included removed benign skin tumors caused by HPV, such as seborrheic keratomas, actinic keratomas, vulgar warts, plantar warts, acrochordones, condyloma accuminatum, and fibropapillomas. The diagnosis was established on the basis of medical history, clinical presentation, and dermoscopy results. DNA was isolated from all the samples followed by bisulfite conversion, PCR-amplification, sequencing, and statistical processing of sequencing results. Results. Hypermethylation of WIF1 gene promoter was detected in all the samples. Conclusion. The observed hypermethylation of WIF1 promoter may lead to decrease in expression level of these gene and activation of WNT-signaling pathway. Activation of WNT-signaling pathway is a possible key factor in the development and recurrence of benign skin lesions caused by HPV. However, further research in this field is required for full understanding of epigenetic mechanisms.