The article describes the clinical and epidemiological features of human papillomavirus infection and reports the results of the complex therapy with Panavir in patients with viral and bacterial multi-infections. Objective. The study was aimed at evaluating the effectiveness of complex therapy with Panavir in patients with viral and bacterial multi-infections. Material and methods. Clinical and laboratory study involved 320 females, the study group included 70 patients diagnosed with HPV infection. Results. When assessing the effectiveness of therapy, it should be noted that there was significant reduction of viral load, pronounced regression of the inflammatory process, higher efficacy of specific antibiotic therapy, normalization of colposcopic picture, reduced area of chronic cervicitis foci and CIN I in more than 68% of patients, as well as elimination of human papilloma virus in 35% of females. Conclusions. The use of immunocorrecting and pathogenetic therapy (such as Panavir), acting on both the pathogen and microorganism, can improve the effectiveness of therapy and substantially reduce the risk of life-threatening consequences of HPV infection