ATF-1, ATF-3 and ATF-4 genes expression in affected skin specimen from patients with morphea

Potekaev N.N.

Moscow Scientific and Practical Center of Dermatovenerology and Cosmetology, Moscow, Russia

Vavilov V.V.

MNPTsDK Departament zdravookhraneniia Moskvy;
Pervyĭ MGMU im. I.M. Sechenova

Sobolev V.V.

N.I. Vavilov Institute of General Genetics, Russian Academy of Sciences, Moscow

Soboleva A.G.

N.I. Vavilov Institute of General Genetics, Russian Academy of Sciences, Moscow

Zolotarenko A.D.

Institut obshcheĭ genetiki im. N.I. Vavilova RAN

Piruzian É.S.

FGBUN Institut obshcheĭ genetiki im. N.I. Vavilova RAN, Moskva

Korsunskaia I.M.

Centre of Theoretical Problems of Physico-Chemical Pharmacology, Russian Academy of Sciences

Bruskin S.A.

N.I. Vavilov Institute of General Genetics, Russian Academy of Sciences, Moscow

ATF-1, ATF-3 and ATF-4 genes expression in affected skin specimen from patients with morphea

Authors:

Potekaev N.N., Vavilov V.V., Sobolev V.V., Soboleva A.G., Zolotarenko A.D., Piruzian É.S., Korsunskaia I.M., Bruskin S.A.

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Journal: Russian Journal of Clinical Dermatology and Venereology. 2013;11(6): 13‑17

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To cite this article:

Potekaev NN, Vavilov VV, Sobolev VV, et al. . ATF-1, ATF-3 and ATF-4 genes expression in affected skin specimen from patients with morphea. Russian Journal of Clinical Dermatology and Venereology. 2013;11(6):13‑17. (In Russ.)

Подписка 2025-2 (Russian Journal of Clinical Dermatology and Venereology)

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The RT-PCR based quantitative analysis of A transcription factor gene expression was carried out and showed the up-regulation of ATF-1, ATF-3 and ATF-4 genes expression in morphea lesions. Overexpression of ATF-1, ATF-3 and ATF-4 genes in affected skin samples was shown to be evident. These findings suggest the concept that these parameters may be used to evaluate the activity of the pathologic process.

Keywords:

morphea

scleroderma

gene expression

RT-PCR

AP-1

TGF-Β

ATF

Authors:

Potekaev N.N.

Moscow Scientific and Practical Center of Dermatovenerology and Cosmetology, Moscow, Russia

Vavilov V.V.

MNPTsDK Departament zdravookhraneniia Moskvy;
Pervyĭ MGMU im. I.M. Sechenova

Sobolev V.V.

N.I. Vavilov Institute of General Genetics, Russian Academy of Sciences, Moscow

Soboleva A.G.

N.I. Vavilov Institute of General Genetics, Russian Academy of Sciences, Moscow

Zolotarenko A.D.

Institut obshcheĭ genetiki im. N.I. Vavilova RAN

Piruzian É.S.

FGBUN Institut obshcheĭ genetiki im. N.I. Vavilova RAN, Moskva

Korsunskaia I.M.

Centre of Theoretical Problems of Physico-Chemical Pharmacology, Russian Academy of Sciences

Bruskin S.A.

N.I. Vavilov Institute of General Genetics, Russian Academy of Sciences, Moscow

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