Current concepts of scleroderma

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The present review considers the data extracted from various literature sources concerning peculiarities of the clinical picture of circumscribed scleroderma. The authors discuss the hypothesis that regards circumscribed and systemic scleroderma as manifestations of one and the same pathological process. This view is based on the reports of unidirectional metabolic disturbances, common mechanisms underlying the development of pathohistological changes of the skin in both forms of the disease, and transformation of the localized process into progressive systemic sclerosis. The data on the incidence and predominance of different forms of circumscribed scleroderma are presented in conjunction with the information about their clinical symptoms, duration of the disease and its relation to other pathological conditions. Different therapeutic modalities (both multi-course and combined) for the treatment of circumscribed scleroderma are analysed.

Keywords:

circumscribed scleroderma

antibiotics

chemotherapy

methotrexate

corticosteroids

photochemotherapy

Authors:

Gurskiĭ G.É.

GBOU VPO "Rostovskiĭ gosudarstvennyĭ meditsinskiĭ universitet", Rostov-na-Donu

Grebennikov V.A.

Rostov State Medical University, Rostov-on-Don

Khoron'ko V.V.

GBOU VPO "Rostovskiĭ gosudarstvennyĭ meditsinskiĭ universitet", Rostov-na-Donu

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