The objective of this work was to evaluate the state of the biliary excretory system in patients with psoriasis and concomitant chronic opisthorchosis. The study included a total of 60 patients with psoriasis and chronic opisthorchosis, 45 patients with psoriasis without helmintosis, and 15 healthy subjects. The patients were examined using chromatic fractional duodenal probing, dynamic hepatobiliscintigraphic and ultrasonic techniques for visualization of liver and gallbladder. The levels of cholesterol, bile acids, bilirubin, total lipids, and phospholipids were measured in the bile. The colloid state of the bile was evaluated from a variety of indirect characteristics, such as cholatocholesterol coefficient, Thomas-Hofmann lithogenicity index, and Rubens lithogenicity index. The study has demonstrated changes in the biliary excretory system of the patients presenting with psoriasis and concurrent chronic opisthorchosis that require antihelminthic therapy to be corrected.