Indocyanine green in liver tumor resection

Close metadata

Recommended articles:

Own experience of indocyanine green use in the diagnosis and treatment of breast cancer in N.N. Petrov NMRC of Oncology. Pirogov Russian Journal of Surgery. 2024;(7):111-114

ICG angiography is a safety standard in bariatric surgery. Pirogov Russian Journal of Surgery. 2024;(7):115-123

Indocyanine green is an integral part of breast reconstructive surgery using perforator flaps. Pirogov Russian Journal of Surgery. 2024;(8):34-40

Experience of indocyanine green use in acute calculous cholecystitis. Pirogov Russian Journal of Surgery. 2024;(8):52-56

The Russian consensus on the treatment of intrahepatic cholangiocarcinoma. Pirogov Russian Journal of Surgery. 2024;(10):7-20

Diagnostic value of fluorescence lymphography for sentinel lymph node biopsy in breast cancer. Summary experience of several specialized centers. Pirogov Russian Journal of Surgery. 2024;(10):49-61

Comparative analysis of laparoscopic cholecystectomy outcomes in acute calculous cholecystitis: importance of indocyanine green, optimal dosing regimen. Pirogov Russian Journal of Surgery. 2024;(11):72-76

Prognostic factors and preoperative therapy in resectable intrahepatic cholangiocarcinoma. Pirogov Russian Journal of Surgery. 2025;(1):5-13

Laparoscopic ALPPS procedure: a series of cases. Pirogov Russian Journal of Surgery. 2025;(2):20-26

Preliminary results of fluorescent lymphography in patients with biliary cancer undergoing liver resection. Pirogov Russian Journal of Surgery. 2025;(2):27-36

Primary liver cancer and colorectal cancer liver metastases are among the leading causes of cancer-related mortality worldwide. Surgery is one of the main methods of treatment to achieve the best results in overall and recurrence-free survival. The main objectives in this surgery are preoperative planning, assessment of functional viability of liver parenchyma and total resection with low complication rate. Post-resection liver failure is one of the most formidable and often fatal complication following functional failure of liver remnant. Thus, preoperative assessment of liver functional reserves is a necessary step for adequate selection of patients and safe surgery. Passive liver tests, such as biochemical parameters or clinical scales, do not accurately reflect the actual functional component of liver parenchyma. The most accurate method is dynamic quantitative test of liver, such as indocyanine green clearance. The authors discuss the practical aspects of preoperative assessment of liver functional reserves using indocyanine green, as well as the concept and technical foundations of fluorescent imaging in hepatobiliary surgery.

Keywords:

post-resection liver failure

liver resection

liver function tests

ICG test

indocyanine green

Authors:

Kaprin A.D.

P.A. Herzen Moscow Oncology Research Institute — Branch of the National Medical Radiology Research Center of Ministry of Russia;
Peoples’ Friendship University of Russia

SPIN RSCI: 1759-8101
Scopus AuthorID: 6602709853
ResearcherID: K-1445-2014
ORCID: 0000-0001-8784-8415

Ivanov S.A.

Tsyb Medical Radiology Research Center

ORCID: 0000-0001-7689-6032

Petrov L.O.

National Medical Research Center for Radiology

ORCID: 0000-0001-6272-9647

Isaeva A.G.

Tsyb Medical Radiology Research Center

ORCID: 0000-0002-3038-5904

Received:

05.06.2023

Accepted:

07.07.2023

List of references:

Andreou A, Brouquet A, Abdalla EK, Aloia TA, Curley SA, Vauthey JN. Repeat hepatectomy for recurrent colorectal liver metastases is associated with a high survival rate. HPB. 2011;13(11):774-782. https://doi.org/10.1111/j.1477-2574.2011.00370.x
Sakka SG. Assessing liver function. Current Opinion in Critical Care. 2007;13(2):207-214. https://doi.org/10.1097/MCC.0b013e328012b268
Inderbitzin D, Muggli B, Ringger A, Beldi G, Gass M, Gloor B, Uehlinger D, Regli B, Reichen J, Candinas D. Molecular absorbent recirculating system for the treatment of acute liver failure in surgical patients. Journal of Gastrointestinal Surgery. 2005;9(8):1155-1161. https://doi.org/10.1016/j.gassur.2005.07.026
Malinchoc M, Kamath PS, Gordon FD, Peine CJ, Rank J, ter Borg PC. A model to predict poor survival in patients undergoing transjugular intrahepatic portosystemic shunts. Hepatology. 2000;31(4):864-871. https://doi.org/10.1053/he.2000.5852
Landsman ML, Kwant G, Mook GA, Zijlstra WG. Light-absorbing properties, stability, and spectral stabilization of indocyanine green. Journal of Applied Physiology. 1976;40(4):575-583. https://doi.org/10.1152/jappl.1976.40.4.575
Guyer DR, Puliafito CA, Monés JM, Friedman E, Chang W, Verdooner SR. Digital indocyanine-green angiography in chorioretinal disorders. Ophthalmology. 1992;99(2):287-291. https://doi.org/10.1016/s0161-6420(92)31981-5
Ogata F, Azuma R, Kikuchi M, Koshima I, Morimoto Y. Novel lymphography using indocyanine green dye for near-infrared fluorescence labeling. Ann Plast Surg. 2007;58(6):652-655. https://doi.org/10.1097/01.sap.0000250896.42800.a2
Kitai T, Inomoto T, Miwa M, Shikayama T. Fluorescence navigation with indocyanine green for detecting sentinel lymph nodes in breast cancer. Breast Cancer. 2005;12(3):211-215. https://doi.org/10.2325/jbcs.12.211
Kusano M, Tajima Y, Yamazaki K, Kato M, Watanabe M, Miwa M. Sentinel node mapping guided by indocyanine green fluorescence imaging: a new method for sentinel node navigation surgery in gastrointestinal cancer. Digestive Surgery. 2008;25(2):103-108. https://doi.org/10.1159/000121905
Rubens FD, Ruel M, Fremes SE. A new and simplified method for coronary and graft imaging during CABG. The Heart Surgery Forum. 2002;5(2):141-144.
Raabe A, Nakaji P, Beck J, Kim LJ, Hsu FP, Kamerman JD, Seifert V, Spetzler RF. Prospective evaluation of surgical microscope-integrated intraoperative near-infrared indocyanine green videoangiography during aneurysm surgery. Journal of Neurosurgery. 2005;103(6):982-989. https://doi.org/10.3171/jns.2005.103.6.0982
de Graaf W, Bennink RJ, Heger M, Maas A, de Bruin K, van Gulik TM. Quantitative assessment of hepatic function during liver regeneration in a standardized rat model. Journal of Nuclear Medicine. 2011;52(2):294-302. https://doi.org/10.2967/jnumed.110.078360
de Graaf W, Häusler S, Heger M, van Ginhoven TM, van Cappellen G, Bennink RJ, Kullak-Ublick GA, Hesselmann R, van Gulik TM, Stieger B. Transporters involved in the hepatic uptake of (99m)Tc-mebrofenin and indocyanine green. Journal of Hepatology. 2011;54(4):738-745. https://doi.org/10.1016/j.jhep.2010.07.047
Faybik P, Hetz H. Plasma disappearance rate of indocyanine green in liver dysfunction. Transplantation Proceedings. 2006;38(3):802-802. https://doi.org/10.1016/j.transproceed.2006.01.049
Wissler EH. Identifying a long standing error in single-bolus determination of the hepatic extraction ratio for indocyanine green. European Journal of Applied Physiology. 2011;111(4):641-646. https://doi.org/10.1007/s00421-010-1678-1
Sakka SG, Reinhart K, Meier-Hellmann A. Prognostic value of the indocyanine green plasma disappearance rate in critically ill patients. Chest. 2002;122(5):1715-1720. https://doi.org/10.1378/chest.122.5.1715
Sakaguchi T, Suzuki A, Unno N, Morita Y, Oishi K, Fukumoto K, Inaba K, Suzuki M, Tanaka H, Sagara D, Suzuki S, Nakamura S, Konno H. Bile leak test by indocyanine green fluorescence images after hepatectomy. American Journal of Surgery. 2010;200(1):19-23. https://doi.org/10.1016/j.amjsurg.2009.10.015
Wang L, Xie L, Zhang N, Zhu W, Zhou J, Pan Q, Mao A, Lin Z, Wang L, Zhao Y. Predictive Value of Intraoperative Indocyanine Green Clearance Measurement on Postoperative Liver Function After Anatomic Major Liver Resection. Journal of Gastrointestinal Surgery. 2020;24(6):1342-1351. https://doi.org/10.1007/s11605-019-04262-5
Paumgartner G. The handling of indocyanine green by the liver. Schweizerische Medizinische Wochenschrift. 1975;105:1-30.
Imamura H, Sano K, Sugawara Y, Kokudo N, Makuuchi M. Assessment of hepatic reserve for indication of hepatic resection: decision tree incorporating indocyanine green test. Journal of Hepato-Biliary-Pancreatic Surgery. 2005;12(1):16-22. https://doi.org/10.1007/s00534-004-0965-9
Kortgen A, Paxian M, Werth M, Recknagel P, Rauchfuss F, Lupp A, Krenn CG, Müller D, Claus RA, Reinhart K, Settmacher U, Bauer M. Prospective assessment of hepatic function and mechanisms of dysfunction in the critically ill. Shock. 2009;32(4):358-365. https://doi.org/10.1097/SHK.0b013e31819d8204
Takamoto T, Hashimoto T, Ichida A, Shimada K, Maruyama Y, Makuuchi M. Surgical Strategy Based on Indocyanine Green Test for Chemotherapy-Associated Liver Injury and Long-Term Outcome in Colorectal Liver Metastases. Journal of Gastrointestinal Surgery. 2018;22(6):1077-1088. https://doi.org/10.1007/s11605-018-3712-2
Ban D, Tanabe M, Kumamaru H, Nitta H, Otsuka Y, Miyata H, Kakeji Y, Kitagawa Y, Kaneko H, Wakabayashi G, Yamaue H, Yamamoto M. Safe dissemination of laparoscopic liver resection in 27,146 cases between 2011 and 2017 From the National Clinical Database of Japan. Annals of Surgery. 2021;274(6):1043-1050. https://doi.org/10.1097/SLA.0000000000003799
Olthof PB, Elfrink AKE, Marra E, Belt EJT, van den Boezem PB, Bosscha K, Consten ECJ, den Dulk M, Gobardhan PD, Hagendoorn J, van Heek TNT, IJzermans JNM, Klaase JM, Kuhlmann KFD, Leclercq WKG, Liem MSL, Manusama ER, Marsman HA, Mieog JSD, Oosterling SJ, Patijn GA, Te Riele W, Swijnenburg RJ, Torrenga H, van Duijvendijk P, Vermaas M, Kok NFM, Grünhagen DJ; Dutch Hepato Biliary Audit Group. Volume-outcome relationship of liver surgery: a nationwide analysis. British Journal of Surgery. 2020;107(7):917-926. https://doi.org/10.1002/bjs.11586
Račkauskas R, Baušys A, Sokolovas V, Paškonis M, Strupas K. Short- and long-term outcomes of surgery for colorectal and non-colorectal liver metastasis: a report from a single center in the Baltic country. World journal of surgical oncology. 2020;18(1):164. https://doi.org/10.1186/s12957-020-01944-2
Benedetti Cacciaguerra A, Görgec B, Cipriani F, Aghayan D, Borelli G, Aljaiuossi A, Dagher I, Gayet B, Fuks D, Rotellar F, D’Hondt M, Vanlander A, Troisi RI, Vivarelli M, Edwin B, Aldrighetti L, Abu Hilal M. Risk factors of positive resection margin in laparoscopic and open liver surgery for colorectal liver metastases: a new perspective in the perioperative assessment: a European multicenter study. Annals of Surgery. 2022;275(1):213-221. https://doi.org/10.1097/SLA.0000000000004077
Marino MV, Podda M, Fernandez CC, Ruiz MG, Fleitas MG. Theapplication of indocyanine green-fluorescence imaging during robotic-assisted liver resection for malignant tumors: a single-arm feasibility cohort study. HPB. 2020;22(3):422-431. https://doi.org/10.1016/j.hpb.2019.07.013
Wakabayashi T, Cacciaguerra AB, Abe Y, Bona ED, Nicolini D, Mocchegiani F, Kabeshima Y, Vivarelli M, Wakabayashi G, Kitagawa Y. Indocyanine Green Fluorescence Navigation in Liver Surgery: A Systematic Review on Dose and Timing of Administration. Annals of Surgery. 2022;275(6):1025-1034. https://doi.org/10.1097/SLA.0000000000005406
Dip F, Boni L, Bouvet M, Carus T, Diana M, Falco J, Gurtner GC, Ishizawa T, Kokudo N, Lo Menzo E, Low PS, Masia J, Muehrcke D, Papay FA, Pulitano C, Schneider-Koraith S, Sherwinter D, Spinoglio G, Stassen L, Urano Y, Vahrmeijer A, Vibert E, Warram J, Wexner SD, White K, Rosenthal RJ. Consensus conference statement on the general use of near-infrared fluorescence imaging and indocyanine green guided surgery: results of a Modified Delphi Study. Annals of Surgery. 2022;275(4):685-691. https://doi.org/10.1097/SLA.0000000000004412
Abo T, Nanashima A, Tobinaga S, Hidaka S, Taura N, Takagi K, Arai J, Miyaaki H, Shibata H, Nagayasu T. Usefulness of intraoperative diagnosis of hepatic tumors located at the liver surface and hepatic segmental visualization using indocyanine green-photodynamic eye imaging. European Journal of Surgical Oncology. 2015;41(2):257-264. https://doi.org/10.1016/j.ejso.2014.09.008
Takahashi H, Zaidi N, Berber E. An initial report on the intraoperative use of indocyanine green fluorescence imaging in the surgical management of liver tumorss. Journal of Surgical Oncology. 2016;114(5):625-629. https://doi.org/10.1002/jso.24363
Zhang YM, Shi R, Hou JC, Liu ZR, Cui ZL, Li Y, Wu D, Shi Y, Shen ZY. Liver tumor boundaries identified intraoperatively using real-time indocyanine green fluorescence imaging. Journal of Cancer Research and Clinical Oncology. 2017;143(1):51-58. https://doi.org/10.1007/s00432-016-2267-4
Handgraaf HJM, Boogerd LSF, Höppener DJ, Peloso A, Sibinga Mulder BG, Hoogstins CES, Hartgrink HH, van de Velde CJH, Mieog JSD, Swijnenburg RJ, Putter H, Maestri M, Braat AE, Frangioni JV, Vahrmeijer AL. Long-term follow-up after near-infrared fluorescence-guided resection of colorectal liver metastases: A retrospective multicenter analysis. European Journal of Surgical Oncology. 2017;43(8):1463-1471. https://doi.org/10.1016/j.ejso.2017.04.016
Peloso A, Franchi E, Canepa MC, Barbieri L, Briani L, Ferrario J, Bianco C, Quaretti P, Brugnatelli S, Dionigi P, Maestri M. Combined use of intraoperative ultrasound and indocyanine green fluorescence imaging to detect liver metastases from colorectal cancer. HPB. 2013;15(12):928-934. https://doi.org/10.1111/hpb.12057
Kudo H, Ishizawa T, Tani K, Harada N, Ichida A, Shimizu A, Kaneko J, Aoki T, Sakamoto Y, Sugawara Y, Hasegawa K, Kokudo N. Visualization of subcapsular hepatic malignancy by indocyanine-green fluorescence imaging during laparoscopic hepatectomy. Surgical Endoscopy. 2014;28(8):2504-2508. https://doi.org/10.1007/s00464-014-3468-z

Close metadata