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Rynda A.Yu.

Polenov Russian Neurosurgery Institute — Branch of the Almazov National Medical Research Center

Olyushin V.E.

Polenov Russian Neurosurgery Institute — Branch of the Almazov National Medical Research Center

Rostovtsev D.M.

Polenov Russian Neurosurgery Institute — Branch of the Almazov National Medical Research Center

Zabrodskaya Yu.M.

Prof. A.L. Polenov Russian Research Institute of Neurosurgery — Branch V.A. Almazov National Medical Research Center of the Ministry of Health of Russia

Papayan G.V.

Pavlov First St. Petersburg State Medical University;
Almazov National Medical Research Center

Comparative analysis of 5-ALA and chlorin E6 fluorescence-guided navigation in malignant glioma surgery

Authors:

Rynda A.Yu., Olyushin V.E., Rostovtsev D.M., Zabrodskaya Yu.M., Papayan G.V.

More about the authors

Journal: Pirogov Russian Journal of Surgery. 2022;(1): 5‑14

DOI: 10.17116/hirurgia20220115

Read: 3967 times

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Table of contents

COMPARATIVE ANALYSIS OF 5-ALA AND CHLORIN E6 FLUORESCENCE-GUIDED NAVIGATION IN MALIGNANT GLIOMA SURGERY
COMPARATIVE ANALYSIS OF 5-ALA AND CHLORIN E6 FLUORESCENCE-GUIDED NAVIGATION IN MALIGNANT GLIOMA SURGERY

To cite this article:

Rynda AYu, Olyushin VE, Rostovtsev DM, Zabrodskaya YuM, Papayan GV. Comparative analysis of 5-ALA and chlorin E6 fluorescence-guided navigation in malignant glioma surgery. Pirogov Russian Journal of Surgery. 2022;(1):5‑14. (In Russ.)
https://doi.org/10.17116/hirurgia20220115

Подписка 2026 Хирургия. Журнал им. Н.И. Пирогова (Pirogov Russian Journal of Surgery)
МСФ на ЯМ
Использование инфографики авторами научных работ
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Abstract:

OBJECTIVE

To analyze specificity and sensitivity of 5-ALA and chlorin E6 fluorescence-guided navigation in malignant glioma surgery.

MATERIAL AND METHODS

Fluorescence-guided navigation was analyzed in 50 patients (2 groups) with high-grade glioma. All patients were treated at the Polenov Russian Neurosurgery Institute. Chlorin E6 1 mg/kg intravenously (Photoditazin) was used as a fluorescence inducer in 25 patients (the 1st group), 5-ALA 20 mg/kg orally (Alasens) — in other 25 patients (the 2nd group). Each group included 10 patients with glioma grade III and 15 patients with glioma grade IV. Both groups were statistically representative (p>0.05).

RESULTS

In patients with glioma grade III, sensitivity of chlorin E6 fluorescence-guided navigation was 83.8%, 5-ALA fluorescence — 82.5%. Specificity was 66.7% and 64.1%, respectively. In patients with glioma grade IV, sensitivity was 87.7% for chlorin E6 and 88.3% for 5-ALA. Specificity was 85.2% and 88.1%, respectively.

CONCLUSION

Statistical analysis confirmed comparable high efficacy of both agents in surgery of malignant gliomas. Sensitivity and specificity of fluorescence-guided navigation with chlorin E6 and 5-ALA were similar (p>0.05).

Keywords:

glioma
fluorescence-guided navigation
chlorin E6
5-ALA
specificity
sensitivity

Authors:

Rynda A.Yu.

Polenov Russian Neurosurgery Institute — Branch of the Almazov National Medical Research Center

Olyushin V.E.

Polenov Russian Neurosurgery Institute — Branch of the Almazov National Medical Research Center

Rostovtsev D.M.

Polenov Russian Neurosurgery Institute — Branch of the Almazov National Medical Research Center

Zabrodskaya Yu.M.

Prof. A.L. Polenov Russian Research Institute of Neurosurgery — Branch V.A. Almazov National Medical Research Center of the Ministry of Health of Russia

Papayan G.V.

Pavlov First St. Petersburg State Medical University;
Almazov National Medical Research Center

Received:

04.03.2021

Accepted:

09.06.2021

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