Venous wall weackness pathogenesis in varicose vein disease

Studennikova V.V.; Severgina L.O.; Sinyavin G.V.; Rapoport L.M.; Korovin I.A.

doi:https://doi.org/10.17116/hirurgia201910169

Studennikova V.V.

Sechenov First Moscow State Medical University, Ministry of Health of the Russia, Moscow, Russia

Severgina L.O.

Sechenov First Moscow State Medical University, Ministry of Health of the Russia, Moscow, Russia

Sinyavin G.V.

Department of Cardiovascular Surgery and Interventional Cardiology, Sechenov First Moscow State Medical University, Moscow, Russia

Rapoport L.M.

Sechenov First Moscow State Medical University of the Russian Healthcare Ministry, Research Institute of Uronephrology and Human Reproductive Health, Moscow, Russia

Korovin I.A.

Sechenov First Moscow State Medical University, Ministry of Health of the Russia, Moscow, Russia

Venous wall weackness pathogenesis in varicose vein disease

Authors:

Studennikova V.V., Severgina L.O., Sinyavin G.V., Rapoport L.M., Korovin I.A.

More about the authors

Journal: Pirogov Russian Journal of Surgery. 2019;(10): 69‑74

DOI: 10.17116/hirurgia201910169

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To cite this article:

Studennikova VV, Severgina LO, Sinyavin GV, Rapoport LM, Korovin IA. Venous wall weackness pathogenesis in varicose vein disease. Pirogov Russian Journal of Surgery. 2019;(10):69‑74. (In Russ.)
https://doi.org/10.17116/hirurgia201910169

Подписка 2026 Хирургия. Журнал им. Н.И. Пирогова (Pirogov Russian Journal of Surgery)

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Abstract:

Varicose veins of lower extremities, varicocele and varicose dilation of pelvic veins including ovaricovaricocele are the most common non-inflammatory diseases of venous system. The same mechanisms determined varicose dilatation regardless localization of the vein. First of all, these are wall weakness and valvular insufficiency combined with hereditary collagen fiber defectiveness in case of undifferentiated connective tissue syndrome. Imbalance between different types of collagen in vascular wall (especially types I and III) also results wall weakness. Other important mechanisms are smooth muscle cells dysfunction followed by excessive intracellular synthesis and intramuscular fibrosis and imbalance of protease system due to overproduction of metalloproteinases. We consider that different forms of varicose veins (varicose veins of lower extremities, varicocele, ovaricovaricocele) may be unified within one pathology (varicose vein disease).

Keywords:

review

mechanisms of varicose veins formation

varicose veins of lower extremities

varicocele

ovaricovaricocele

genetic factors

syndrome of undifferentiated connective tissue dysplasia

Authors:

Studennikova V.V.

Sechenov First Moscow State Medical University, Ministry of Health of the Russia, Moscow, Russia

Severgina L.O.

Sechenov First Moscow State Medical University, Ministry of Health of the Russia, Moscow, Russia

Sinyavin G.V.

Department of Cardiovascular Surgery and Interventional Cardiology, Sechenov First Moscow State Medical University, Moscow, Russia

Rapoport L.M.

Sechenov First Moscow State Medical University of the Russian Healthcare Ministry, Research Institute of Uronephrology and Human Reproductive Health, Moscow, Russia

Korovin I.A.

Sechenov First Moscow State Medical University, Ministry of Health of the Russia, Moscow, Russia

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References:

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