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Mezenova T.V.

Russian Academy of Postgraduate Education, Moscow, Russia

Forced osteoarthritis therapy: expanding the scope of the possible

Authors:

Mezenova T.V.

More about the authors

Journal: Pirogov Russian Journal of Surgery. 2018;(5): 91‑95

DOI: 10.17116/hirurgia2018591-95

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FORCED OSTEOARTHRITIS THERAPY: EXPANDING THE SCOPE OF THE POSSIBLE
FORCED OSTEOARTHRITIS THERAPY: EXPANDING THE SCOPE OF THE POSSIBLE

To cite this article:

Mezenova TV. Forced osteoarthritis therapy: expanding the scope of the possible. Pirogov Russian Journal of Surgery. 2018;(5):91‑95. (In Russ.)
https://doi.org/10.17116/hirurgia2018591-95

Подписка 2025-2 (Pirogov Russian Journal of Surgery)
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The article deals the modern concepts of the mechanism of pain in osteoarthritis. It was established that synovial inflammation and immune disorders play an important role in the pathogenesis of pain in osteoarthritis. Hyperproduction of pro-inflammatory cytokines supports inflammation and degradation of cartilaginous tissue in osteoarthritis. The mechanisms of pathogenetic action of chondroitin sulfate are disclosed, and the evidence base of its preclinical and clinical studies in the treatment of osteoarthritis is presented. The data of clinical application of the Mucosat — pharmaceutical substance chondroitin sulfate in the form of a ready-made dosage form for intramuscular injection are presented. The practical advantages of including SYSADOA in complex therapy of osteoarthritis are discussed.

Keywords:

osteoarthritis
pain
proinflammatory cytokines
chondroprotectors
chondroitin sulfate
Mucosat

Authors:

Mezenova T.V.

Russian Academy of Postgraduate Education, Moscow, Russia

List of references:

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  2. Ivkin DYu, Ivkina AS. Symptoms of delayed action in the therapy of osteoarthritis. Lechaschii vrach. 2012;7:100-104. (In Russ.) https://www.lvrach.ru/2012/07/15435482/
  3. Folomeeva OM, Erdes ShF. Prevalence and social significance of rheumatic diseases in the Russian Federation. Doktor (revmatologiya). 2007;10:3-12. (In Russ.)
  4. WHO Scientific Group on the Burden of Musculoskeletal Conditions at the Start of the Millennium. The Burden of Musculoskeletal Disease at the Start of the Millennium: report of a WHO scientific group. Geneva: WHO; 2003. http://www.who.int/iris/handle/10665/42721
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  8. Baici A, Bradamante P. Interaction between human leukocyte elastase and chondroitin sulfate. Chemico-Biological Interactions. 1984;51:1-11. https://doi.org/10.1016/0009-2797(84)90015-2
  9. Monfort J, Nacher M, Montell E, Vila J, Verges J, Benito P. Chondroitin sulfate and Hyaluronic acid (500―730 kDa) inhibit stromelysin-1 synthesis in human osteoarthritic chondrocytes. Drugs under experimental and clinical research. 2005;31:71-76.
  10. Chou MM, Vergnolle N, McDougall JJ, Wallace JL, Marty S, Teskey V, Buret AG. Effects of chondroitin and glucosamine sulfate in a dietary bar formulation on inflammation, interleukin-1beta, matrix metalloprotease-9, and cartilage damage in arthritis. Experimental Biology and Medicine. 2005;230:255-262.
  11. Martel-Pelletier J, Roubille C, Abram F, Hochberg MC, Dorais M, Delorme P, Raynauld J-P, Pelletier J-P. First-line analysis of the effects of treatment on progression of structural changes in knee osteoarthritis over 24 months: data from the osteoarthritis initiative progression cohort. Annals of the Rheumatic Diseases. 2015;74(3):547-556. https://doi.org/10.1136/annrheumdis-2013-203906
  12. Verbruggen G, Veys EM. Influence of sulphated glycosaminoglycans upon proteoglycan metabolism of the synovial lining cells. Acta Rhumatologica Belgica. 1977;1:75-92.
  13. Lippielo L, Grande D. In vivo chondroprotection of glucosamine and chondroitin sulfate in a rabbit model of a OA and demonstration of metabolic synergy on chondrocyte in vitro. Annals of the Rheumatic Diseases. 2000;59(I):266.
  14. Chan PS, Caron JP, Orth MW. Shot-term gene expression changes in cartilage explants stimulated with interleukin beta plus glucosamine and chondroitin sulfate. Journal of Rheumatology. 2006;33:1329-1340.
  15. Conrozier Т. Death of articular chondrocytes. Mechanisms and protection. Presse Medicale. 1998;21:1859-1861.
  16. Largo R, Sanches-Pernaute O, Moreno-Rubio J. Chondroitin sulfate prevents synovial inflammation in an experimental model of chronic arthritis, which might be mediated by the inhibition of the NF-kB dependent pathway. Osteoarthritis and Cartilage. 2008;16(4):28-29.
  17. Ronca F, Palmieri L, Panicucci P, Ronca G. Anti-inflammatory activity of chondroitin sulfate. Osteoarthritis and Cartilage. 1998;6(A):14-21.
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  19. Henrotin Y, Lambert С. Chondroitin and Glucosamine in the Management of Osteoarthritis: An Update. Current Rheumatology Reports. 2013;15:361. https://doi.org/10.1007/s11926-013-0361-z
  20. Henrotin Y, Marty M, Mobasheri A. What is the current status of chondroitin sulfate and glucosamine for the treatment of knee osteoarthritis? Maturitas. 2014;78:184-187. https://doi.org/10.1016/j.maturitas.2014.04.015.
  21. Blitterswijk WJ, van de Nes JCM, Wuisman PIJM. Glucosamine and chondroitin sulfate supplementation to treat symptomatic disc degeneration: Biochemical rationale and case report. BMC Complementary and Alternative Medicine. 2003;3(1):2. https://doi.org/10.1186/1472-6882-3-2
  22. Zhang W, Doherty M, Arden N, Bannwarth B, Bijlsma J, Gunther KP, Hauselmann HJ, Herrero-Beaumont G. EULAR evidence based recommendations for the management of hiposteoarthritis: report of a task force of the EULAR Standing Committee for International Clinical Studies Including Therapeutics (ESCISIT). Annals of the Rheumatic Diseases. 2005;64(5):669-681. https://doi.org/10.1136/ard.2004.028886
  23. Singh JA, Noorbaloochi S, MacDonald R, Maxwell LJ. Chondroitin for osteoarthritis. Cochrane Database of Systematic Reviews. 2015;1. https://doi.org/10.1002/14651858.CD005614.pub2
  24. Danilov AB. The antinociceptive effect of chondroprotectors is a myth or a reality? Manage pain. 2018;1:8-13. (In Russ.) http://logospress.ru/data/med/MP/2018/1-2018/Danilov-1_MP-1-2018.pdf
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