Rivaroxaban as monotherapy in patients with venous thromboembolism

Krivoshchekov E.P.; Migunov I.A.; Romanov V.E.

doi:https://doi.org/10.17116/hirurgia20161061-65

Krivoshchekov E.P.

V.D. Seredavin Samara Regional Clinical Hospital, Samara State Medical University, Ministry of Health of the Russian Federation, Samara, Russia

Migunov I.A.

V.D. Seredavin Samara Regional Clinical Hospital, Samara State Medical University, Ministry of Health of the Russian Federation, Samara, Russia

Romanov V.E.

V.D. Seredavin Samara Regional Clinical Hospital, Samara State Medical University, Ministry of Health of the Russian Federation, Samara, Russia

Rivaroxaban as monotherapy in patients with venous thromboembolism

Authors:

Krivoshchekov E.P., Migunov I.A., Romanov V.E.

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Journal: Pirogov Russian Journal of Surgery. 2016;(10): 61‑65

DOI: 10.17116/hirurgia20161061-65

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To cite this article:

Krivoshchekov EP, Migunov IA, Romanov VE. Rivaroxaban as monotherapy in patients with venous thromboembolism. Pirogov Russian Journal of Surgery. 2016;(10):61‑65. (In Russ.)
https://doi.org/10.17116/hirurgia20161061-65

Подписка 2026 Хирургия. Журнал им. Н.И. Пирогова (Pirogov Russian Journal of Surgery)

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Abstract:

Venous thromboembolism is the major cause of death and important health problem. Anticoagulants is the mainstay modality of VTE treatment and rivaroxaban was the first novel anticoagulant approved for VTE treatment and secondary prevention in Russia. Current study was designed to assess efficacy and safety of rivaroxaban from the first day of VTE treatment. There were 78 patients in control group treated with LMWH and VKA, and 46 patients in the rivaroxaban group. Treatment duration was not less than 3 months. After 3 months there were 3 (3.85%) patients in control group and 1 (2.2%) patient in the rivaroxaban group with thrombus deterioration. Bleeding complications were observed in 6 (7.7%) patients in LMWH/VKA group and in 2 (4.3%) patients in the rivaroxaban group. In conclusion, results of the study show favorable benefit profile of rivaroxaban in VTE patients and rivaroxaban could be considered as initial therapy.

Keywords:

deep vein thrombosis

oral anticoagulant

pulmonary embolism

rivaroxaban

Authors:

Krivoshchekov E.P.

V.D. Seredavin Samara Regional Clinical Hospital, Samara State Medical University, Ministry of Health of the Russian Federation, Samara, Russia

Migunov I.A.

V.D. Seredavin Samara Regional Clinical Hospital, Samara State Medical University, Ministry of Health of the Russian Federation, Samara, Russia

Romanov V.E.

V.D. Seredavin Samara Regional Clinical Hospital, Samara State Medical University, Ministry of Health of the Russian Federation, Samara, Russia

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References:

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