Contemporary diagnostic algorithm for coronary artery disease: achievements and prospects

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This review is devoted to the algorithm of the diagnosis of coronary artery disease (CAD) with analysis of the possibilities and shortcomings of conventional instrumental techniques and new laboratory research methods. The authors analyzed the prospects for simultaneous use of the well-known invasive and non-invasive (coronary angiography, contrast-enhanced multispiral computed tomography of the coronary arteries, stress-echocardiography, etc.) imaging methods and new non-invasive biomarkers in the diagnosis and stratification of the risk of CAD. Cellular (peripheral blood mononuclear cells, endothelial progenitor cells), biochemical (transforming growth factor beta (TGF-beta1), cell adhesion molecules (CAM), monocyte chemoattractant protein-1 (MCP-1), stromal cell factor 1a (SDF-1a), lectin-like receptor of low-density oxidized lipoproteins 1 (LOX-1), pentraxin 3 (PTX3), etc.), and epigenetic biomarkers (miR-208a, miR-499, miR-133 and miR -1 and others) are analyzed.

Keywords:

coronary angiography

contrast-enhanced multispiral computed tomography of the coronary arteries

microRNA

CAD

ACS

circulating biomarkers

Authors:

Ngo Bilong Ekedi Anzh Veronik

Sechenov First Moscow State Medical University of the Ministry of Health of the Russia, Moscow, Russia

Akselrod A.S.

Sechenov First Moscow State Medical University of Healthcare Ministry of the Russia, Moscow, Russia, Federal Research Clinical Center for Physico-Chemical Medicine, FMBA of Russia, Moscow, Russia

Shchekochikhin D.Iu.

Pervyĭ Moskovskiĭ gosudarstvennyĭ meditsinskiĭ universitet im. I.M. Sechenova;
Moskovskiĭ gosudarstvennyĭ universitet im. M.V. Lomonosova

Tebenkova E.S.

Sechenov First Moscow State Medical University of the Ministry of Health of the Russia, Moscow, Russia

Zhelankin A.V.

Sechenov First Moscow State Medical University of Healthcare Ministry of the Russia, Moscow, Russia, Federal Research Clinical Center for Physico-Chemical Medicine, FMBA of Russia, Moscow, Russia

Stonogina D.A.

Sechenov First Moscow State Medical University of Healthcare Ministry of the Russia, Moscow, Russia, Federal Research Clinical Center for Physico-Chemical Medicine, FMBA of Russia, Moscow, Russia

Syrkina E.A.

Chair of Preventive and Emergency Cardiology, Research Center of Mental Health RAS, Moscow, Russia

Ternovoy S.K.

FGBU National medical research cardiology center of Russia, Moscow, Russia

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