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Stonogina D.A.
Sechenov First Moscow State Medical University of Healthcare Ministry of the Russia, Moscow, Russia, Federal Research Clinical Center for Physico-Chemical Medicine, FMBA of Russia, Moscow, Russia
Zhelankin A.V.
Sechenov First Moscow State Medical University of Healthcare Ministry of the Russia, Moscow, Russia, Federal Research Clinical Center for Physico-Chemical Medicine, FMBA of Russia, Moscow, Russia
Akselrod A.S.
Sechenov First Moscow State Medical University of Healthcare Ministry of the Russia, Moscow, Russia, Federal Research Clinical Center for Physico-Chemical Medicine, FMBA of Russia, Moscow, Russia
Generozov E.V.
Sechenov First Moscow State Medical University of Healthcare Ministry of the Russia, Moscow, Russia, Federal Research Clinical Center for Physico-Chemical Medicine, FMBA of Russia, Moscow, Russia
Shchekochikhin D.Iu.
Pervyĭ Moskovskiĭ gosudarstvennyĭ meditsinskiĭ universitet im. I.M. Sechenova;
Moskovskiĭ gosudarstvennyĭ universitet im. M.V. Lomonosova
Vasilyev S.V.
Department of Surgical Diseases, Acad. I.P. Pavlov First Saint Petersburg State Medical University, Ministry of Health of Russia, Saint Petersburg, Russia
Syrkin A.L.
Sechenov First Moscow State Medical University
Circulating miRNAs as risk biomarkers of cardiovascular complications in patients with coronary artery disease: achievements and difficulties of recent years
Journal: Russian Journal of Cardiology and Cardiovascular Surgery. 2019;12(1): 17‑24
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To cite this article:
Stonogina DA, Zhelankin AV, Akselrod AS, Generozov EV, Shchekochikhin DIu, Vasilyev SV, Syrkin AL. Circulating miRNAs as risk biomarkers of cardiovascular complications in patients with coronary artery disease: achievements and difficulties of recent years. Russian Journal of Cardiology and Cardiovascular Surgery.
2019;12(1):17‑24. (In Russ.)
https://doi.org/10.17116/kardio20191201117
We presented the results of the latest studies devoted to diagnostic and prognostic value of circulating plasma/serum miRNAs in patients with different subtypes of coronary artery disease (CAD). Diagnostic value was shown for miR-133a, miR-134, miR-145, miR-1 and miR-370 for patients with different severity of coronary atherosclerosis. MiR-133a/b, miR-208a/b and miR-499 indicated independent prognostic and diagnostic results in some cases more accurate than hs-cTnT among patients with acute coronary syndrome. In addition, the review shows association of some miRNAs (miR-133a, miR-208/b, miR-499, miR-150, miR-380, miR-145) with high risk of cardiac death and heart failure in CAD patients. Different combinations of miRNA have predictive value of CAD among healthy patients.
Authors:
Stonogina D.A.
Sechenov First Moscow State Medical University of Healthcare Ministry of the Russia, Moscow, Russia, Federal Research Clinical Center for Physico-Chemical Medicine, FMBA of Russia, Moscow, Russia
Zhelankin A.V.
Sechenov First Moscow State Medical University of Healthcare Ministry of the Russia, Moscow, Russia, Federal Research Clinical Center for Physico-Chemical Medicine, FMBA of Russia, Moscow, Russia
Akselrod A.S.
Sechenov First Moscow State Medical University of Healthcare Ministry of the Russia, Moscow, Russia, Federal Research Clinical Center for Physico-Chemical Medicine, FMBA of Russia, Moscow, Russia
Generozov E.V.
Sechenov First Moscow State Medical University of Healthcare Ministry of the Russia, Moscow, Russia, Federal Research Clinical Center for Physico-Chemical Medicine, FMBA of Russia, Moscow, Russia
Shchekochikhin D.Iu.
Pervyĭ Moskovskiĭ gosudarstvennyĭ meditsinskiĭ universitet im. I.M. Sechenova;
Moskovskiĭ gosudarstvennyĭ universitet im. M.V. Lomonosova
Vasilyev S.V.
Department of Surgical Diseases, Acad. I.P. Pavlov First Saint Petersburg State Medical University, Ministry of Health of Russia, Saint Petersburg, Russia
Syrkin A.L.
Sechenov First Moscow State Medical University
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