Circulating miRNAs as risk biomarkers of cardiovascular complications in patients with coronary artery disease: achievements and difficulties of recent years

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We presented the results of the latest studies devoted to diagnostic and prognostic value of circulating plasma/serum miRNAs in patients with different subtypes of coronary artery disease (CAD). Diagnostic value was shown for miR-133a, miR-134, miR-145, miR-1 and miR-370 for patients with different severity of coronary atherosclerosis. MiR-133a/b, miR-208a/b and miR-499 indicated independent prognostic and diagnostic results in some cases more accurate than hs-cTnT among patients with acute coronary syndrome. In addition, the review shows association of some miRNAs (miR-133a, miR-208/b, miR-499, miR-150, miR-380, miR-145) with high risk of cardiac death and heart failure in CAD patients. Different combinations of miRNA have predictive value of CAD among healthy patients.

Keywords:

miRNA

coronary artery disease

acute coronary syndrome

circulating biomarkers

Authors:

Stonogina D.A.

Sechenov First Moscow State Medical University of Healthcare Ministry of the Russia, Moscow, Russia, Federal Research Clinical Center for Physico-Chemical Medicine, FMBA of Russia, Moscow, Russia

Zhelankin A.V.

Sechenov First Moscow State Medical University of Healthcare Ministry of the Russia, Moscow, Russia, Federal Research Clinical Center for Physico-Chemical Medicine, FMBA of Russia, Moscow, Russia

Akselrod A.S.

Sechenov First Moscow State Medical University of Healthcare Ministry of the Russia, Moscow, Russia, Federal Research Clinical Center for Physico-Chemical Medicine, FMBA of Russia, Moscow, Russia

Generozov E.V.

Sechenov First Moscow State Medical University of Healthcare Ministry of the Russia, Moscow, Russia, Federal Research Clinical Center for Physico-Chemical Medicine, FMBA of Russia, Moscow, Russia

Shchekochikhin D.Iu.

Pervyĭ Moskovskiĭ gosudarstvennyĭ meditsinskiĭ universitet im. I.M. Sechenova;
Moskovskiĭ gosudarstvennyĭ universitet im. M.V. Lomonosova

Vasilyev S.V.

Department of Surgical Diseases, Acad. I.P. Pavlov First Saint Petersburg State Medical University, Ministry of Health of Russia, Saint Petersburg, Russia

Syrkin A.L.

Sechenov First Moscow State Medical University

Scopus AuthorID: 7103104759
ORCID: 0000-0002-9602-292X

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