Aim — to establish features of ACS patoautokinesis and mexidol’s effect on its course using infrared spectrometry of blood lipid-phospholipid complexes. Material and methods. 120 patients with ACS were enrolled including 39 (group 1) with following unstable angina, 19 (group 2)  — non-Q-myocardial infarction, and 62 (group 3) — Q-myocardial infarction. 90 patients of subgroup A did not receive mexidol and 30 — received antioxidant therapy (subgroup B). We investigated common laboratory parameters and the percentage of lipid-phospholipid complexes absorption in serum using infrared spectrometry before and during intravenous administration of mexidol 250 mg for 10 days. The control group consisted of 20 healthy people. Results. It was first found that serum concentration of lipid-phospholipid complexes is the highest in case of unstable angina, it relatively reduces in non-Q- and especially in case of Q- myocardial infarction. Their concentration exceeds control data at the first day of disease and continues to grow by the 10th day in case of unstable angina and especially non-Q-myocardial infarction with less pronounced increase in case of Q-myocardial infarction. Use of mexidol in standard therapy enhances the positive multimodal effect of endogenous phospholipids on regression of myocardial necrobiotic processes.