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Safronenko A.V.

GBOU VPO "Rostovskiĭ gosudarstvennyĭ meditsinskiĭ universitet Minzdravsotsrazvitiia RF"

Makliakov Iu.S.

GBOU VPO "Rostovskiĭ gosudarstvennyĭ meditsinskiĭ universitet Minzdravsotsrazvitiia RF"

Demidov I.A.

GBOU VPO "Rostovskiĭ gosudarstvennyĭ meditsinskiĭ universitet Minzdravsotsrazvitiia RF"

Lavnik D.V.

GBOU VPO "Rostovskiĭ gosudarstvennyĭ meditsinskiĭ universitet Minzdravsotsrazvitiia RF"

Luk'ianchikov M.K.

GBOU VPO "Rostovskiĭ gosudarstvennyĭ meditsinskiĭ universitet Minzdravsotsrazvitiia RF"

Condition and functional reserves of endothelium in patients with refractory arterial hypertension

Authors:

Safronenko A.V., Makliakov Iu.S., Demidov I.A., Lavnik D.V., Luk'ianchikov M.K.

More about the authors

Journal: Russian Journal of Cardiology and Cardiovascular Surgery. 2012;5(6): 44‑47

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Table of contents

CONDITION AND FUNCTIONAL RESERVES OF ENDOTHELIUM IN PATIENTS WITH REFRACTORY ARTERIAL HYPERTENSION
CONDITION AND FUNCTIONAL RESERVES OF ENDOTHELIUM IN PATIENTS WITH REFRACTORY ARTERIAL HYPERTENSION

To cite this article:

Safronenko AV, Makliakov IuS, Demidov IA, Lavnik DV, Luk'ianchikov MK. Condition and functional reserves of endothelium in patients with refractory arterial hypertension. Russian Journal of Cardiology and Cardiovascular Surgery. 2012;5(6):44‑47. (In Russ.)

Подписка 2025-2 (Russian Journal of Cardiology and Cardiovascular Surgery)
 
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Specifics of metabolic stability of endotheliocytes and significance of this phenomenon in endothelium-related vasodilation were studied in patients with refractory arterial hypertension. 42 patients with refractory arterial hypertension were enrolled in the study. Tests with metacholine and additional administration of ascorbic acid as well as with reactive hyperemia were carried out. It is shown that loss of endothelial tolerance to cytotoxic substances is observed in every third patient accompanied by progressive reduction of vasculomotor endothelial function of systemic vessels and decreased endothelium-related vasodilation.

Keywords:

refractory arterial hypertension
endothelial dysfunction
endothelium-related vasodilation.

Authors:

Safronenko A.V.

GBOU VPO "Rostovskiĭ gosudarstvennyĭ meditsinskiĭ universitet Minzdravsotsrazvitiia RF"

Makliakov Iu.S.

GBOU VPO "Rostovskiĭ gosudarstvennyĭ meditsinskiĭ universitet Minzdravsotsrazvitiia RF"

Demidov I.A.

GBOU VPO "Rostovskiĭ gosudarstvennyĭ meditsinskiĭ universitet Minzdravsotsrazvitiia RF"

Lavnik D.V.

GBOU VPO "Rostovskiĭ gosudarstvennyĭ meditsinskiĭ universitet Minzdravsotsrazvitiia RF"

Luk'ianchikov M.K.

GBOU VPO "Rostovskiĭ gosudarstvennyĭ meditsinskiĭ universitet Minzdravsotsrazvitiia RF"

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