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Charnaia M.A.

RNTsKh im. akad. B.V. Petrovskogo RAMN, Moskva

Morozov Iu.A.

RNTsKh im. akad. B.V. Petrovskogo RAMN, Moskva

Concentrates of prothrombin complex in treatment of coagulopathy of non-hemophilic genesis (literary review)

Authors:

Charnaia M.A., Morozov Iu.A.

More about the authors

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To cite this article:

Charnaia MA, Morozov IuA. Concentrates of prothrombin complex in treatment of coagulopathy of non-hemophilic genesis (literary review). Russian Journal of Cardiology and Cardiovascular Surgery. 2012;5(2):104‑108. (In Russ.)

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References:

  1. Dement'eva I.I., Charnaya M.A., Morozov Yu.A. Sistema gemostaza pri operatsiyakh na serdtse i magistral'nykh sosudakh. M: GEOTAR-Media 2009; 373-394.
  2. Sukhanova G.A., Vdovin V.V., Svirin P.V. Vozmozhnosti primeneniya preparata Protrompleks v klinicheskoi praktike. Tromboz gemostaz i reologiya 2011; 1: 24-30.
  3. Aguilar M.I., Hart R.G., Kase C.S. et al. Treatment of warfarin-associated intracerebral hemorrhage: Literature review and expert opinion. Mayo Clin Proc 2007; 82: 82-92.
  4. Allen G.A., Wolberg A.S., Oliver J.A. et al. Impact of procoagulant concentration on rate, peak and total thrombin generation in a model system. J Thromb Haemost 2004; 2: 402-413.
  5. Ansell J., Hirsh J., Poller L. et al. The Pharmacology and Management of the Vitamin K Antagonists. Chest 2004; 126: 204-233.
  6. Baglin T. Recommendations from the British Committee for Standards in Haematology and National Patient Safety Agency. Br J Haematol 2007; 136: 26-29.
  7. Bagot C.N., Cregg R.K., Patel R.K. et al. Perioperative myocardial infarction in a patient receiving low dose prothrombin complex concentrate. Thromb Haemost 2007; 98: 1141-1142.
  8. Bruce D., Nokes T.J. Prothrombin complex concentrate (Beriplex P/N) in severe bleeding: experience in a large tertiary hospital. Crit Care 2008; 12: 105.
  9. Cartmill M., Dolan G., Byrne J.L., Byrne P.O. Prothrombin complex concentrate for oral anticoagulant reversal in neurosurgical emergencies. Br J Neurosurg 2000; 14: 458-461.
  10. Demeyere R., Gillardin S., Arnout J., Strengers P.F. Comparison of fresh frozen plasma and prothrombin complex concentrate for the reversal of oral anticoagulants in patients undergoing cardiopulmonary bypass surgery: a randomized study. Vox Sanguinis 2010; 99: 251-260.
  11. Dickneite G., Pragst I. Prothrombin complex concentrate vs fresh frozen plasma for reversal of dilutional coagulopathy in a porcine trauma model. Br J Anaesth 2009; 102: 3: 345-354.
  12. Dickneite G. Prothrombin complex concentrate versus recombinant factor VIIa for reversal of coumarin anticoagulation. Thromb Res 2007; 19: 5: 643-651.
  13. Dusel C.H., Grundmann C., Eich S. et al. Identification of prothrombin as a major thrombogenic agent in prothrombin complex concentrates. Blood Coagul Fibrinolysis 2004; 15: 405-411.
  14. Erber W.N., Perry D.J. Plasma and plasma products in the treatment of massive haemorrhage. Best Pract Res Clin Haematol 2006; 19: 1: 97-112.
  15. Ferraris V.A., Brown J.R., Despotis G.J. et al. 2011 Update to The Society of Thoracic Surgeons and the Society of Cardiovascular Anesthesiologists Blood Conservation Clinical Practice Guidelines. Ann Thorac Surg 2011; 91: 944-982.
  16. Fraser T.A., Corke C.F., Mohajeri M. et al. A retrospective audit of the use of Prothrombinex-HT for refractory bleeding following adult cardiac surgery. Crit Care Res 2006; 8: 141-145.
  17. Fredriksson K., Norrving B., Stromblad L.G. Emergency reversal of anticoagulation after intracerebral hemorrhage. Stroke 1992; 23: 972-977.
  18. Gallistl S., Cvirn G., Leschnik B., Muntean W. Respective roles of factors II, VII, IX and X in procoagulant activity of FEIBA. Blood Coagul Fibrinolysis 2002; 13: 653-655.
  19. Godier A., Durand M., Emmerich J. et al. Efficacy of prothrombin complex concentrate to reverse the anticoagulant effect of the pentasaccharide fondaparinux in a rabbit model. Thromb Haemost 2011; 105: 1: 161-168.
  20. Grottke O., Braunschweig T., Spronk H.M.H. et al. Increasing concentrations of prothrombin complex concentrate induce disseminated intravascular coagulation in a pig model of coagulopathy with blunt liver injury. Blood 2011; 118: 7: 1943-1951.
  21. Hirsh J., Dalen J.E., Anderson D.R. et al. Oral anticoagulants: mechanism of action, clinical effectiveness, and optimal therapeutic range. Chest 1998; 114: Suppl 5: 445S-469S.
  22. Holland L., Warkentin T.E., Refaai M. Suboptimal effect of a three-factor prothrombin complex concentrate (Profilnine-SD) in correcting supratherapeutic international normalized ratio due to warfarin overdose. Transfusion 2009; 49: 6: 1171-1177.
  23. Kaspereit F., Hoffman S., Pragst I., Dickneite G. Prothrombin complex concentrate mitigates diffuse bleeding after cardiopulmonary bypass in a porcine model. Br J Anaesth 2010; 105: 5: 576-582.
  24. Key N.S., Negrier C. Coagulation factor concentrates: past, present and future. Lancet 2007; 370: 439-448.
  25. Kohler M. Thrombogenicity of prothrombin complex concentrate. Thromb Res 1999; 95: S13-S17.
  26. Kozek-Langenecker S. Management of massive operative blood loss. Minerva Anestesiol 2007; 73: 401-415.
  27. Lankiewicz M.W., Hays J., Friedman K.D. et al. Urgent reversal of warfarin with prothrombin complex concentrate. J Thromb Haemost 2006; 4: 967-970.
  28. Leissinger C.A., Blatt P.M., Hoots W.K., Ewenstein B. Role of prothrombin complex concentrates in reversing wapfarin anticoagulation: a review of the literature. Am J Hematol 2007; 83: 137-143.
  29. Levy J.H., Tanaka K.A., Dietrich W. Perioperative hemostatic management of patients treated with vitamin K antagonists. Anesthesiology 2008; 109: 905-917.
  30. Lorenz R., Kienast J., Otto U. et al. Successful emergency reversal of phenprocoumon anticoagulation with prothrombin complex concentrate: a prospective clinical study. Blood Coagul Fibrinolysis 2007; 18: 6: 565-570.
  31. Lubetsky A., Hoffman R., Zimlichman R. et al. Efficacy and safety of a prothrombin complex concentrate (Octaplex) for rapid reversal of oral anticoagulation. Thromb Res 2004; 113: 6: 371-378.
  32. Makris M., Greaves M., Phillips W.S. et al. Emergency oral anticoagulant reversal: the relative efficacy of infusions of fresh frozen plasma and clotting factor concentrate on correction of the coagulopathy. Thromb Haemost 1997; 77: 477-480.
  33. Makris M., Watson H.G. The management of coumarininduced over-anticoagulation Annotation. Br J Haematol 2001; 114: 271-280.
  34. Mayer S.A., Rincon F. Ultra-early hemostatic therapy for acute intracerebral hemorrhage. Semin Hematol 2006; 43: S70-76.
  35. Ostermann H., Haertel S., Knaub S. et al. Pharmacokinetics of Beriplex P/N prothrombin complex concentrate in healthy volunteers. Thromb Haemost 2007; 98: 790-797.
  36. Pabinger I., Brenner B., Kalina U. et al. Prothrombin complex concentrate (Beriplex((R)) P/N) for emergency anticoagulation reversal: a prospective multinational clinical trial. J Thromb Haemost 2008; 6: 622-631.
  37. Pabinger I., Tiede A., Kalina U. et al. Impact of infusion speed on the safety and effectiveness of prothrombin complex concentrate: a prospective clinical trial of emergency anticoagulation reversal. Ann Hematol 2010; 89: 3: 309-316.
  38. Samama C.M. Prothombin complex concentrates: a brief review. Eur J Anaesth 2008; 25: 784-789.
  39. Schick K.S., Fertmann J.M., Jauch K.W., Hoffmann J.N. Prothrombin complex concentrate in surgical patients: retrospective evaluation of vitamin K antagonist reversal and treatment of severe bleeding. Crit Care 2009; 13: 6: 191.
  40. Schochl H., Nienaber U., Hofer G. Goal-directed coagulation management of major trauma patients using thromboelastometry (ROTEM(R))-guided administration of fibrinogen concentrate and prothrombin complex concentrate. Crit Care 2010; 14: R55.
  41. Sniecinski R., Szlam F., Chen E.P. et al. Antithrombin deficiency increases thrombin activity after prolonged cardiopulmonary bypass. Anesth Analg 2008; 106: 713- 718.
  42. Sørensen B., Spahn D.R., Innerhofer P. et al. Prothrombin complex concentrates - evaluation of safety and thrombogenicity. Critical Care 2011; 15: 201-223.
  43. Stadinger T., Frass M., Rintelen C. et al. Influence prothrombin complex concentrates on plasma coagulation in critical ill patients. Int Care Med 1999; 25: 1105-1110.
  44. Stuklis R.G., O'Shaughnessy D.F., Ohri S.K. Novel approach to bleeding in patients undergoing cardiac surgery with liver dysfunction. Eur J Cardio Thorac Surg 2001; 19: 219-220.
  45. van Aart L., Eijkhout HW., Kamphuis J.S. et al. Individualized dosing regimen for prothrombin complex concentrate more effective than standard treatment in the reversal of oral anticoagulant therapy: an open, prospective randomized controlled trial. Thromb Res 2006; 118: 313-320.
  46. Vigue B., Ract C., Tremey B. et al. Ultra-rapid management of oral anticoagulant therapy-related surgical intracranial hemorrhage. Int Care Med 2007; 33: 721-725.
  47. Warren O., Simon B. Massive, fatal, intracardiac thrombosis associated with prothrombin complex concentrate. Ann Emerg Med 2009; 53: 758-761.
  48. Xi M., Beguin S., Hemker H.C. The relative importance of the factors II, VII, IX and X for the prothrombinase activity in plasma of orally anticoagulated patients. Thromb Haemost 1989; 62: 788-791.
  49. Yasaka M., Sakata T., Naritomi H., Minematsu K. Optimal dose of prothrombin complex concentrate for acute reversal of oral anticoagulation. Thromb Res 2005; 115: 455-459.
  50. Yusuf S., Mehta S.R., Chrolavicius S. et. al. Efficacy and safety of fondaparinux compared to enoxaparin in 20 078 patients with acute coronary syndromes without ST-segment elevation. The OASIS-5 Investigators. N Engl J Med 2006; 354: 1464-1476.

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