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Gumba V.M.

Pervyĭ MGMU im. I.M. Sechenova, klinika kardiologii

Giliarov M.Yu.

I.M. Sechenov First Moscow State Medical University under the Ministry of Health of the Russia, 119991, Moscow, Russia;
N.I. Pirogov Moscow Municipal Hospital №1, Moscow, 119049, Russia

Novikova N.A.

Pervyĭ MGMU im. I.M. Sechenova, klinika kardiologii

Impact of proxodolol and metoprolol on left ventricle remodeling in patients with prior myocardial infarction

Authors:

Gumba V.M., Giliarov M.Yu., Novikova N.A.

More about the authors

Journal: Russian Journal of Cardiology and Cardiovascular Surgery. 2012;5(1): 14‑17

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Table of contents

IMPACT OF PROXODOLOL AND METOPROLOL ON LEFT VENTRICLE REMODELING IN PATIENTS WITH PRIOR MYOCARDIAL INFARCTION
IMPACT OF PROXODOLOL AND METOPROLOL ON LEFT VENTRICLE REMODELING IN PATIENTS WITH PRIOR MYOCARDIAL INFARCTION

To cite this article:

Gumba VM, Giliarov MYu, Novikova NA. Impact of proxodolol and metoprolol on left ventricle remodeling in patients with prior myocardial infarction. Russian Journal of Cardiology and Cardiovascular Surgery. 2012;5(1):14‑17. (In Russ.)

Подписка 2025-2 (Russian Journal of Cardiology and Cardiovascular Surgery)
 
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Impact of prodoxolol and metoprolol on post-infarction left ventricle remodeling was comparatively evaluated. 60 patients aged 37-75 years (mean age 58±9 years) were included in randomized prospective trial. It is shown that therapy with prodoxolol and metoprolol in patients with prior myocardial infarction provides equal improvement of echocardiographic indices (decrease in size of left heart chambers, increase of global myocardial contractility).

Keywords:

myocardial infarction
post-infarction remodeling
alpha- and beta-blockers
echocardiograph

Authors:

Gumba V.M.

Pervyĭ MGMU im. I.M. Sechenova, klinika kardiologii

Giliarov M.Yu.

I.M. Sechenov First Moscow State Medical University under the Ministry of Health of the Russia, 119991, Moscow, Russia;
N.I. Pirogov Moscow Municipal Hospital №1, Moscow, 119049, Russia

Novikova N.A.

Pervyĭ MGMU im. I.M. Sechenova, klinika kardiologii

List of references:

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  2. Florya V.G. Rol' remodelirovaniya levogo zheludochka v patogeneze khronicheskoi nedostatochnosti krovoobrashchenii. Kardiologiya 1997; 5: 63-67.
  3. Duncker D., Boontje NM., Merkus D. et al. Prevention of myofilament dysfunction by beta-blocker therapy in post-infarct remodeling. Circ Heart Fail 2009.
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  5. Gajarsa J., Kloner R. Left ventricular remodeling in the post-infarction heart: a review of cellular, molecular mechanisms, and therapeutic modalities. Heart Fail Rev 2011; 16: 1: 13-21.
  6. Landmesser U., Wollert K., Drexler H. Potential novel pharmacological therapies for myocardial remodeling. Cardiovasc Res 2009; 81: 519-527.
  7. Pocock S., Henderson R., Seed P. et al. Quality of life, employment status, and anginal symptoms after coronary angioplasty or bypass surgery. 3-year follow-up in the Randomized Intervention Treatment of Angina (RITA) Trial. Circulation 1996; 94: 135-142.
  8. Rossini R., Senni M., Musumeci G. et al. Prevention of left ventricular remodelling after acute myocardial infarction: an update. Recent Pat Cardiovasc Drug Dis 2010; 5: 3: 196-207.
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  10. Vilahur G., Juan-Babot O., Peña E. et al. Molecular and cellular mechanisms involved in cardiac remodeling after acute myocardial infarction. J Mol Cell Cardiol 2011; 50: 3: 522-533.

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