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Atkov O.Yu.

FSBEI FPE Russian Medical Academy of Continuous Professional Education, 2/1, Barrikadnaya ul., 125993 Moscow, Russian Federation

Gorokhova S.G.

FSBEI FPE Russian Medical Academy of Continuous Professional Education, 2/1, Barrikadnaya ul., 125993 Moscow, Russian Federation

Circadian genes and circulatory system

Authors:

Atkov O.Yu., Gorokhova S.G.

More about the authors

Journal: Russian Cardiology Bulletin. 2019;14(2): 36‑42

DOI: 10.17116/Cardiobulletin20191402136

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CIRCADIAN GENES AND CIRCULATORY SYSTEM
CIRCADIAN GENES AND CIRCULATORY SYSTEM

To cite this article:

Atkov OYu, Gorokhova SG. Circadian genes and circulatory system. Russian Cardiology Bulletin. 2019;14(2):36‑42. (In Russ.)
https://doi.org/10.17116/Cardiobulletin20191402136

 
Подписка 2025-2 (Russian Cardiology Bulletin)
 
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It is now assumed that the main parameters of cardiovascular system have diurnal rhythmicity, which is defined by molecular and genetic biological clock based on circadian genes that are found in suprachiasmatic nuclei of hypothalamus as well as in other parts of the body including heart and vessels. These circadian genes play an important role in regulation of blood pressure, heart rhythm, hemostatic systems, and in other processes. Many studies also demonstrated that circadian genes have a pleiotropic effect and control many non-circadian genes. Mutations in circadian genes are associated with a range of cardiovascular diseases including arterial hypertension, myocardial infarction, and cardiomyopathy. The clarification of the role of circadian genetic mechanisms presents a new opportunity to solve complex problems of general and individual therapeutic approaches to the treatment of cardiovascular diseases.

Keywords:

circadian genes
circadian rhythm
hypertension
myocardial infarction
arrhythmogenesis
thrombosis

Authors:

Atkov O.Yu.

FSBEI FPE Russian Medical Academy of Continuous Professional Education, 2/1, Barrikadnaya ul., 125993 Moscow, Russian Federation

Gorokhova S.G.

FSBEI FPE Russian Medical Academy of Continuous Professional Education, 2/1, Barrikadnaya ul., 125993 Moscow, Russian Federation

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