The current state of phlebology is characterized by the rapid appearance of the new tools for the treatment of chronic venous disease (CVD). The large number of modifications suggested for this purpose by the specialists require the careful comparative evaluation of their efficacy and safety. It is nearly impossible to conduct separate individual studies for elucidating this issue. This problem can be solved by using a register in which prospectively accumulate the results of treatment by different methods. It is implies the creation of the national registry of the methods for the treatment of chronic venous diseases. Aim — the objective of the present study was to design and develop a registry of the methods for the treatment of chronic venous diseases. Material and methods. We designed a registry in the form of an open continuous cumulative database. The online platform on which it is located includes standard information parts, sections for the data import and export, and a section with auxiliary tools that can be used without registration in the system. The registry allows to introduce a detailed description of the patients, as well as the detailed information about the surgical interventions, their outcomes, and follow-up observations. Data entry and storage are organized in the form of case reports containing references to the initial data cards and control visits cards. The relevant data can be entered both retrospectively and prospectively. The interface makes it possible to fill the data either selectively or in an arbitrary order. The registry provides the randomization system for randomized controlled trials (RCT). Some data are automatically pre-processed before being entered. The export of the registry database is available to any registered user. The differential access to the data of interest guarantees copyright protection of individual studies. Pre-filters are available to simplify interactions with the database. Results. The Registry was opened in 2016 under the auspices of the Russian Phlebological Association. It has been registered on ClinicalTrials.gov. Currently, there are two randomized clinical trials and one observational study that are carried out based on the registry platform. Data harvesting for one observational study of a new medication is already completed. To date, as many as 166 participants are included in the registry into which the information about 3306 cases has been downloaded; 1622 of them are characterized based on the data of follow-up observations and control visits cards. Conclusions. The Russian Registry of the Methods for the Treatment of Chronic Venous Diseases is the actively used and continuously replenished database which has provided the basis for designing and conducting clinical studies. As increasingly more information becomes available, we expect to receive a significant volume of prospective and retrospective data for the analysis of a variety of clinical and epidemiological issues.