Aim — the objective the present study was to determine the frequency and localization of deep vein thrombosis in the patient with the fractures of bones and/or large joints who received the treatment with anticoagulants to prevent venous thromboembolism and had indications for the surgical treatment of the bone and joint injuries. Material and methods. The study included 221 patients with venous thromboembolism and concomitant multiple bone fractures or joint injuries receiving the course of anticoagulant prophylaxis. Duplex ultrasnjuriesound was performed to evaluate the condition of the deep venous system in the lower extremities on day 5.0±0.6 after the admission to the hospital. Results. Venous thromboembolism (VTE) was documented in 6.5% of the patients. Pulmonary embolism (PE) was diagnosed in two cases. 55.1% of the patients with venous thromboembolism suffered from the femoral or hip fractures, 21.4% of such patients had injuries to the shinbones, and 23.5% experienced a multiple trauma. Thrombosis of femoral or popliteal veins was the most frequently registered condition (51.3%). The cases of distal thrombosis prevailed among the patients with the fractures of shinbones (60.1%) due to the direct traumatic impact on the deep veins. Bilateral thrombosis was found in 20.8% of the patients. The thrombus with the free-floating proximal part was found in 46.2% of the cases. Conclusion. Venous thromboembolism developed in 6.5% of the patients with multiple bone fractures or joint injuries receiving the course of anticoagulant therapy at the prophylactic doses. The duplex ultrasound study should be used as an indispensable component of the examination of such patients for the early detection of deep vein thrombosis and the timely correction of the algorithm of the anticoagulation treatment.