Aim — the objective of the present study was to estimate the immediate results of combined therapy including the anticoagulant agents in the patients presenting with varicose vein thrombophlebitis. Material and methods. The study involved 45 patients with varicose veins in the lower extremities who underwent a course of conservative therapy with the use of anticoagulants for the treatment of acute superficial vein thrombophlebitis. The group of the patients was comprised of 9 (20%) men and 36 (80%) women at the age varying from 28 to 78 (mean 54.6) years. After the threat of thrombosis spreading onto the deep venous system had been eliminated, all the patients were given the  course of conservative treatment including the administration of direct anticoagulants at the therapeutic doses, non-steroidal anti-inflammatory drugs (NSAIDs), local anti-inflammatory therapy, wearing compression stockings, therapeutic physical exercises, and dosed walking. All these therapeutic procedures were initiated on the day of onset of the treatment. The patients were followed up during two months. Results. The clinical and ultrasound examination revealed positive dynamics of the patients’ conditions. At least two variants of dynamics were distinguished depending on the thrombus reaction to the therapeutic intervention: (A) the relatively rapid response associated with the changes in the thrombus within the first week after the onset of the treatment was apparent in 11 patients; and (B) the relatively slow response characterized by the development of changes during one months was documented in 34 patients. Conclusion. The introduction of anticoagulant agents into the combined treatment of varicose vein thrombophlebitis is both effective and safe. The most probable significant factors responsible for the rapid restoration of the venous lumen include the early treatment starting from the time of thrombus formation (i.e. duration of thrombosis), low echodensity of the proximal part of the thrombus, the thickness of the paravasal cellular tissue less than 5 mm in the projection of this part and  along the length of thrombotic masses.