Evaluation of depth of invasion is important for decision on radical endoscopic removal of early colorectal cancer. Objectives: To carry out comparative analysis of different methods of evaluation of tumor invasion depth. Materials and methods: In 59 patients with suspicious early colorectal cancer endoscopic ultrasonography, endoscopic characterization of tumor surface and lifting of the lesion by submucous liquid injection. Comparison of accuracy, sensitivity and specificity of the methods in preoperative evaluation of depth of tumor invasion has been carried out. Exclusion criteria were: Ip tumor, recurrent cancer and tumor on the background of inflammatory bowel disease. Results: Inclusion criteria in the study were noted in 49 patients. Due to histological grade high-differentiated adenocarcinoma were the most common - 65.9%. Average tumor size was 18.8±2.04 mm. Stage 0 and Is tumors were revealed in most cases (55.3%). In 42.6% of cases tumors were localized in the rectum. 48.9% of tumors had submucous invasion and 10.7% - grew into the muscular layer of the intestinal wall. Accuracy, sensitivity and specificity of evaluation of the structure of surface in differential diagnosis of deep and superficial tumors comprised 91.5, 90.9 and 91.6%, respectively that was superior to the values of EUS (82.9, 72.7 and 86.1%) and lifting method (87.2, 54.5 and 97.2%). Accuracy of combination of the methods amounted to: evaluation of structure of surface+EUS - 94.4%, EUS+lifting - 97.2%, evaluation of structure of surface+lifting - 100%. Conclusion: Use of combination of methods for evaluation of depth of invasion enables to advance diagnostic accuracy.