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Skvortsova T.A.

Morozov Children’s City Clinical Hospital;
N.I. Pirogov Russian National Research Medical University

Kildiyarova R.R.

I.M. Sechenov First Moscow State Medical University (Sechenov University)

Telikova S.V.

I.M. Sechenov First Moscow State Medical University (Sechenov University)

Kozlov M.Yu.

Morozov Children’s City Clinical Hospital

Nikitin A.V.

Morozov Children’s City Clinical Hospital;
N.I. Pirogov Russian National Research Medical University

Osovetskaya Yu.L.

I.M. Sechenov First Moscow State Medical University (Sechenov University)

Goryacheva O.A.

Morozov Children’s City Clinical Hospital;
N.I. Pirogov Russian National Research Medical University

An aggressive variant of Crohn’s disease in a teenage girl. (Case report)

Authors:

Skvortsova T.A., Kildiyarova R.R., Telikova S.V., Kozlov M.Yu., Nikitin A.V., Osovetskaya Yu.L., Goryacheva O.A.

More about the authors

Journal: Russian Journal of Evidence-Based Gastroenterology. 2024;13(1): 115‑120

DOI: 10.17116/dokgastro202413011115

Views: 2632

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Table of contents

AN AGGRESSIVE VARIANT OF CROHN’S DISEASE IN A TEENAGE GIRL. (CASE REPORT)
AN AGGRESSIVE VARIANT OF CROHN’S DISEASE IN A TEENAGE GIRL. (CASE REPORT)

To cite this article:

Skvortsova TA, Kildiyarova RR, Telikova SV, Kozlov MYu, Nikitin AV, Osovetskaya YuL, Goryacheva OA. An aggressive variant of Crohn’s disease in a teenage girl. (Case report). Russian Journal of Evidence-Based Gastroenterology. 2024;13(1):115‑120. (In Russ.)
https://doi.org/10.17116/dokgastro202413011115

Подписка 2025-2 (Russian Journal of Evidence-Based Gastroenterology)
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OBJECTIVE

To describe the course of the hormone-resistant form of Crohn’s disease, complicated by sepsis and gastrointestinal bleeding that required surgical intervention.

CASE REPORT

Inflammatory bowel diseases in adolescent patients often present with an atypical onset and a more severe progression, leading to frequent complications. The article describes a case of Crohn’s disease in a 17-year-old girl, complicated by gastrointestinal bleeding and pancytopenia. More aggressive therapy involving intestinal resection of the ileocecal angle was necessary given the history of hormone resistance and the concurrent Klebsiella sepsis.

CONCLUSION

The presented clinical case clearly demonstrates the severity of the disease in a teenager, as well as challenges involved in choosing conservative therapy.

Keywords:

inflammatory bowel diseases
Crohn’s disease
adolescence
clinical case
sepsis

Authors:

Skvortsova T.A.

Morozov Children’s City Clinical Hospital;
N.I. Pirogov Russian National Research Medical University

Kildiyarova R.R.

I.M. Sechenov First Moscow State Medical University (Sechenov University)

Telikova S.V.

I.M. Sechenov First Moscow State Medical University (Sechenov University)

Kozlov M.Yu.

Morozov Children’s City Clinical Hospital

Nikitin A.V.

Morozov Children’s City Clinical Hospital;
N.I. Pirogov Russian National Research Medical University

Osovetskaya Yu.L.

I.M. Sechenov First Moscow State Medical University (Sechenov University)

Goryacheva O.A.

Morozov Children’s City Clinical Hospital;
N.I. Pirogov Russian National Research Medical University

Received:

11.12.2023

Accepted:

23.02.2024

List of references:

  1. Gorelov AV, Yablokova EA, Borisova EV, Polotnyanko EYu. Features of treatment of complicated Crohn’s disease in a 17-year-old girl. Doktor Ru. 2016;6(123):28-31. (In Russ.).
  2. Shcherbakova OV, Poddubny IV, Kozlov MYu. Complicated Crohn’s disease in adolescents: features, indications for surgical treatment, difficulties in transition to adulthood (literature review). Colonoproctologiya. 2017;4(62):88-98. (In Russ.).
  3. Rosen MJ, Dhawan A, Saeed SA. Inflammatory Bowel Disease in Children and Adolescents. JAMA Pediatrics. 2015;169(11): 1053-1060. https://doi.org/10.1001/jamapediatrics.2015.1982
  4. Vernier-Massouille G, Balde M, Salleron J, Turck D, Dupas JL, Mouterde O, Merle V, Salomez JL, Branche J, Marti R, Lerebours E, Cortot A, Gower-Rousseau C, Colombel JF. Natural history of pediatric Crohn’s disease: a population-based cohort study. Gastroenterology. 2008;135(4):1106-1113. https://doi.org/10.1053/j.gastro.2008.06.079
  5. Sabel’nikova EA, Krums LM. Peculiarities of diagnostics of small intestine pathology. Dokazatel`naya gastroe`nterologiya. 2013;(4):39-43. (In Russ.).
  6. Akhrieva KhM, Kogan EA, Tertychnyi AS, Radenska-Lopovok SG, Zairatyants OV, Selivanova LS. Assessment of histologic activity in colitis. Arkhiv patologii. 2022;84(2):51-57. (In Russ.). https://doi.org/10.17116/patol20228402151
  7. Sheriff MZ, Mansoor E, Luther J, Ananthakrishnan AN, Abou Saleh M, Ho E, Briggs FBS, Dave M. Opportunistic Infections Are More Prevalent in Crohn’s Disease and Ulcerative Colitis: A Large Population-Based Study. Inflammatory Bowel Diseases. 2020;26(2):291-300.  https://doi.org/10.1093/ibd/izz147
  8. Bengoechea JA, Sa Pessoa J. Klebsiella pneumoniae infection biology: living to counteract host defences. FEMS Microbiology Reviews. 2019;43(2):123-144.  https://doi.org/10.1093/femsre/fuy043
  9. Holmes CL, Anderson MT, Mobley HLT, Bachman MA. Pathogenesis of Gram-Negative Bacteremia. Clinical Microbiology Reviews. 2021;34(2):e00234-20.  https://doi.org/10.1128/CMR.00234-20
  10. Hsu JY, Chuang YC, Wang JT, Chen YC, Hsieh SM. Healthcare-associated carbapenem-resistant Klebsiella pneumoniae bloodstream infections: Risk factors, mortality, and antimicrobial susceptibility, 2017-2019. Journal of the Formosan Medical Association. 2021;120(11):1994-2002. https://doi.org/10.1016/j.jfma.2021.04.014
  11. Bondarenko AL, Krasnykh AI, Poponin MV, Shironina NL. A case of sepsis of Klebsiella etiology. E`pidemiologiya i infekcionny`e bolezni. 2001;4:35-36. (In Russ.).
  12. Danilov MA, Demidova AA, Leontev AV, Tsvirkun VV. Early Ileocecal Resection for Crohn’s Disease. Dokazatel’naya gastroenterologiya. 2023;12(3):10-17. (In Russ.). https://doi.org/10.17116/dokgastro20231203110

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