The site of the Media Sphera Publishers contains materials intended solely for healthcare professionals.
By closing this message, you confirm that you are a certified medical professional or a student of a medical educational institution.

Login
EN
+7 (495) 482-4118
+7 (495) 482-4329
+8 800 250-18-12
  • (toll-free number for subscriptions)
    Mon-Fri from 10 a.m. to 6 p.m.

  • © 1998-2026
+7 (495) 482-43-29
EN
All journals
Journal
Year
Year
Search result: 0

Dyachuk E.E.

Novosibirsk State Medical University

Ageeva T.A.

Novosibirsk State Medical University

Voronina E.I.

Novosibirsk State Medical University

Seliakova M.S.

Novosibirsk State Medical University

Primary lymphoma of the central nervous system

Authors:

Dyachuk E.E., Ageeva T.A., Voronina E.I., Seliakova M.S.

More about the authors

Journal: Russian Journal of Archive of Pathology. 2025;87(6): 56‑60

DOI: 10.17116/patol20258706156

Read: 619 times

Buy for 300₽
Contact the author
Table of contents

PRIMARY LYMPHOMA OF THE CENTRAL NERVOUS SYSTEM
PRIMARY LYMPHOMA OF THE CENTRAL NERVOUS SYSTEM

To cite this article:

Dyachuk EE, Ageeva TA, Voronina EI, Seliakova MS. Primary lymphoma of the central nervous system. Russian Journal of Archive of Pathology. 2025;87(6):56‑60. (In Russ.)
https://doi.org/10.17116/patol20258706156

Подписка 2026 Архив патологии (Russian Journal of Archive of Pathology)
МСФ на ЯМ
Использование инфографики авторами научных работ
Recommended articles:
The impact of combined immu­notherapy on the cellular composition of the tumor microenvironment in patients with gastric carcinoma. Russian Journal of Archive of Pathology. 2025;(4):24-30
Characteristics of the immune microenvironment of endo­metrial cancer depe­nding on the MMR status of the tumor. Russian Journal of Archive of Pathology. 2025;(5):11-19
An improved algo­rithm for gene­tic diagnostics of aggressive B-cell lymphomas in pediatric onco­hematology: the expe­rience of the Dmitry Roga­chev National Medi­cal Research Center of Pediatric Hema­tology, Onco­logy and Immu­nology. Russian Journal of Archive of Pathology. 2026;(1):5-10
The role of the tumor microenvironment and BAP1 protein expression in the prognosis of uveal mela­noma. Russian Annals of Ophthalmology. 2026;(2):21-28
Abstract:

Primary central nervous system lymphoma is a rare type of extranodal non-Hodgkin’s lymphoma that occurs primarily in the central nervous system and represented by diffuse B-cell large cell lymphoma. Despite the fact that this tumor has been known for almost 100 years, studying it is difficult due to the rarity and, consequently, the limited number of statistically significant samples for research. This review analyzes the available literature data on the biological features of primary central nervous system lymphomas, pathogenesis and tumor microenvironment. In addition, we analyzed prognostic factors and current treatment strategies. The objective of this review is to determine the prospects for further study of this tumor.

Keywords:

primary CNS lymphoma
tumor microenvironment
diffuse B-cell large cell lymphoma

Authors:

Dyachuk E.E.

Novosibirsk State Medical University

Ageeva T.A.

Novosibirsk State Medical University

Voronina E.I.

Novosibirsk State Medical University

Seliakova M.S.

Novosibirsk State Medical University

Received:

29.05.2025

Accepted:

25.06.2025

Close metadata

References:

  1. WHO Classification of Tumours Editorial Board. Haematolymphoid tumours. (WHO classification of tumours series, 5th ed.; vol. 11). France, Lyon: IARC; 2024. https://publications.iarc.who.int/637
  2. Bailey P. Intracranial sarcomatous tumors of leptomeningeal origin. Arch Surg. 1929;8:1359-1402. https://doi.org/10.1001/archsurg.1929.01140130449031
  3. Cherkashina IV, Vernyuk MA, Chervontseva AM, et al. Modern aspects of the diagnosis and treatment of primary central nervous system lymphomas. P.A.Herzen Journal of Oncology. 2022;11(6):49-56. (In Russ.). https://doi.org/10.17116/onkolog20221106149
  4. Hoffman S, Propp JM, McCarthy BJ. Temporal trends in incidence of primary brain tumors in the United States, 1985—1999. Neuro Oncol. 2006;8(1):27-37.  https://doi.org/10.1215/S1522851705000323
  5. Mendez JS, Ostrom QT, Gittleman H, et al. The elderly left behind-changes in survival trends of primary central nervous system lymphoma over the past 4 decades. Neuro Oncol. 2018;20(5): 687-694.  https://doi.org/10.1093/neuonc/nox187
  6. Gandhi MK, Hoang T, Law SC, et al. Ebv-associated primary CNS lymphoma occurring after immunosuppression is a distinct immunobiological entity. Blood. 2021;137(11):1468-1477. https://doi.org/10.1182/blood.2020008520
  7. Patel N, Charate R. Diagnosis of primary CNS lymphoma in a HIV patient with multiple ring-enhancing lesions. IDCases. 2021;24:e01065. https://doi.org/10.1016/j.idcr.2021.e01065
  8. Chatterjee S, Angelov L, Ahluwalia MS, Yeaney GA. Epstein-Barr virus-associated primary central nervous system lymphoma in a patient with diffuse cutaneous systemic sclerosis on long-term mycophenolate mofetil. Joint Bone Spine. 2020;87(2):163-166.  https://doi.org/10.1016/j.jbspin.2019.10.005
  9. Brandsma D, Bromberg JEC. Primary CNS lymphoma in HIV infection. Handb Clin Neurol. 2018;152:177-186.  https://doi.org/10.1016/B978-0-444-63849-6.00014-1
  10. Sugita Y, Terasaki M, Niino D, et al. Epstein-Barr virus-associated primary central nervous system lymphomas in immunocompetent elderly patients: analysis for latent membrane protein-1 oncogene deletion and EBNA-2 strain typing. J Neurooncol. 2010;100(2): 271-279.  https://doi.org/10.1007/s11060-010-0191-z
  11. Corboy JR, Garl PJ, Kleinschmidt-DeMasters BK. Human herpesvirus 8 DNA in CNS lymphomas from patients with and without AIDS. Neurology. 1998;50(2):335-340.  https://doi.org/10.1212/wnl.50.2.335
  12. Foster H, Piper K, DePledge L, et al. Human cytomegalovirus seropositivity is associated with decreased survival in glioblastoma patients. Neurooncol Adv. 2019;1(1):vdz020. https://doi.org/10.1093/noajnl/vdz020
  13. Hickey WF. Leukocyte traffic in the central nervous system: the participants and their roles. Semin Immunol. 1999;11(2):125-137.  https://doi.org/10.1006/smim.1999.0168
  14. Aspelund A, Antila S, Proulx ST, et al. A dural lymphatic vascular system that drains brain interstitial fluid and macromolecules. J Exp Med. 2015;212(7):991-999.  https://doi.org/10.1084/jem.20142290
  15. Muldoon LL, Lewin SJ, Dosa E, et al. Imaging and therapy with rituximab anti-CD20 immunotherapy in an animal model of central nervous system lymphoma. Clin Cancer Res. 2011;17:2207-2215. https://doi.org/10.1158/1078-0432.ccr-10-2923
  16. Zyablitskaya EYu, Kubyshkin AV, Sorokina LE, et al. Cellular microenvironment as an object of targeted therapy for malignant neoplasms. Advances in Molecular Oncology. 2023;10(4):8-20. (In Russ.). https://doi.org/10.17650/2313-805X-2023-10-4-8-20
  17. Ponzoni M, Berger F, Chassagne-Clement C, et al; International Extranodal Lymphoma Study Group. Reactive perivascular T-cell infiltrate predicts survival in primary central nervous system B-cell lymphomas. Br J Haematol. 2007;138(3):316-323.  https://doi.org/10.1111/j.1365-2141.2007.06661.x
  18. Berghoff AS, Ricken G, Widhalm G, et al. PD1 (CD279) and PD-L1 (CD274, B7H1) expression in primary central nervous system lymphomas (PCNSL). Clin Neuropathol. 2014;33(1):42-49.  https://doi.org/10.5414/NP300698
  19. Sasayama T, Nakamizo S, Nishihara M, et al. Cerebrospinal fluid interleukin-10 is a potentially useful biomarker in immunocompetent primary central nervous system lymphoma (PCNSL). Neuro Oncol. 2012;14(3):368-380.  https://doi.org/10.1093/neuonc/nor203
  20. Ikeda H, Kawase K, Nishi T, et al. Immune evasion through mitochondrial transfer in the tumour microenvironment. Nature. 2025;638(8049):225-236.  https://doi.org/10.1038/s41586-025-08764-y
  21. Cai Q, Fang Y, Young KH. Primary Central Nervous System Lymphoma: Molecular Pathogenesis and Advances in Treatment. Transl Oncol. 2019;12(3):523-538.  https://doi.org/10.1016/j.tranon.2018.11.011
  22. Bruno A, Boisselier B, Labreche K, et al. Mutational analysis of primary central nervous system lymphoma. Oncotarget. 2014;5(13):5065-5075. https://doi.org/10.18632/oncotarget.2080
  23. Rubenstein JL, Fridlyand J, Shen A, et al. Gene expression and angiotropism in primary CNS lymphoma. Blood. 2006;107(9):3716-3723. https://doi.org/10.1182/blood-2005-03-0897
  24. Koroleva DA, Zvonkov EE, Shchetsova OO, et al. Biopsy-free diagnosis of primary diffuse large B-cell lymphoma of the central nervous system. Russian Journal of Hematology and Transfusiology (Gematologiya i transfuziologiya). 2024;69(3):368-383. (In Russ.). https://doi.org/10.35754/0234-5730-2024-69-3-368-383
  25. Khan RB, Shi W, Thaler HT, et al. Is intrathecal methotrexate necessary in the treatment of primary CNS lymphoma? J Neurooncol. 2002;58(2):175-178.  https://doi.org/10.1023/a:1016077907952
  26. Kumar R, Laack N, Pollock BE, et al. Stereotactic Radiosurgery in the Treatment of Recurrent CNS Lymphoma. World Neurosurg. 2015;84:390-397.  https://doi.org/10.1016/j.wneu.2015.03.062
  27. Nepal G, Khurana M, Bucheli DH, et al. Ibrutinib in Refractory or Relapsing Primary Central Nervous System Lymphoma: A Systematic Review. Neurol Int. 2022;14(1):99-108.  https://doi.org/10.3390/neurolint14010009
  28. Cook MR, Dorris CS, Makambi KH, et al. Toxicity and efficacy of CAR T-cell therapy in primary and secondary CNS lymphoma: a meta-analysis of 128 patients. Blood Adv. 2023;7(1):32-39.  https://doi.org/10.1182/bloodadvances.2022008525
  29. Alcantara M, Fuentealba J, Soussain C. Emerging Landscape of Immunotherapy for Primary Central Nervous System Lymphoma. Cancers (Basel). 2021;13(20):5061. https://doi.org/10.3390/cancers13205061
  30. Houillier C, Soussain C, Ghesquières H, et al. Management and outcome of primary CNS lymphoma in the modern era: An LOC network study. Neurology. 2020;94(10):e1027-e1039. https://doi.org/10.1212/WNL.0000000000008900
  31. Ohanyan S, Buxbaum C, Stein P, et al. Prognostic Impacts of Age, Diagnosis Time, and Relapses in Primary CNS Lymphoma. Journal of Clinical Medicine. 2024;13(16):4745. https://doi.org/10.3390/jcm13164745
  32. Tao K, Wang X, Tian X. Relapsed Primary Central Nervous System Lymphoma: Current Advances. Front Oncol. 2021;11:649789. https://doi.org/10.3389/fonc.2021.649789
Contact the author
Email
Message
The publishing house "Media Sphere" does not provide treatment services, does not give recommendations on contacting medical institutions and specific specialists, on the prescription of medicines and dietary supplements.

Email Confirmation

An email was sent to test@gmail.com with a confirmation link. Follow the link from the letter to complete the registration on the site.

Email Confirmation

Submit Application

You can become an author of one of our magazines, send a request and we will consider it in during the day.

Name
Phone
E-mail
Message
Login
Registration
E-mail
Password
Forgot Password?

Log in to the site using your account in one of the services

Password recovery
E-mail
Login
Register

We use cооkies to improve the performance of the site. By staying on our site, you agree to the terms of use of cооkies. To view our Privacy and Cookie Policy, please. click here.