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Akhrieva Kh.M.

Ingush State University

Kogan E.A.

Sechenov First Moscow State Medical University

Tertychnyi A.S.

I.M. Sechenov First Moscow State Medical University (Sechenov University) of the Ministry of Health of Russia

Radenska-Lopovok S.G.

I.M. Sechenov First Moscow State Medical University

Zairatyants O.V.

Research Institute of Human Morphology;
Moscow State Medical and Dental University named after A.I. Evdokimov

Selivanova L.S.

National Medical Research Center of Endocrinology of the Ministry of Health of Russia

A new look at colonic mucosal structural rearrangement and the stages of chronic colitis

Authors:

Akhrieva Kh.M., Kogan E.A., Tertychnyi A.S., Radenska-Lopovok S.G., Zairatyants O.V., Selivanova L.S.

More about the authors

Journal: Russian Journal of Archive of Pathology. 2021;83(6): 14‑19

DOI: 10.17116/patol20218306114

Views: 5177

Downloaded: 199

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Table of contents

To cite this article:

Akhrieva KhM, Kogan EA, Tertychnyi AS, Radenska-Lopovok SG, Zairatyants OV, Selivanova LS. A new look at colonic mucosal structural rearrangement and the stages of chronic colitis. Russian Journal of Archive of Pathology. 2021;83(6):14‑19. (In Russ.)
https://doi.org/10.17116/patol20218306114

Подписка 2025 (Russian Journal of Archive of Pathology)
МСФ на ЯМ
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OBJECTIVE

To revise the existing criteria to improve the definition of chronic colitis stages in inflammatory bowel diseases (IBDs).

MATERIAL AND METHODS

A total of 100 cases of IBDs (ulcerative colitis (n=70) and Crohn’s disease (n=30) diagnosed in 2017 to 2019 were examined. Thirty patients with colitis were selected for a comparison group, who were assigned to an infective colitis group or a drug-induced colitis one at the final diagnosis.

RESULTS

The sequence of chronic colitis stages was defined from Stage 1 (early changes) to Stage 3, which are characterized by progressive mucosal structural rearrangement. Mainly at Stage 3 that characterizes the final stage of structural rearrangement in the mucous membrane, where dysplastic changes (the onset of tumor transformation) are detected.

CONCLUSION

For the diagnosis of chronic colitis in IBD, it is mandatory to detect mucosal structural rearrangement. Stages 1 and 2 are characterized by early structural changes in the mucous membrane, whereas the process becomes irreversible at Stage 3. The identification of colitis stages is of diagnostic and, undoubtedly, prognostic value.

Keywords:

inflammatory bowel disease
chronic colitis
staging

Authors:

Akhrieva Kh.M.

Ingush State University

Kogan E.A.

Sechenov First Moscow State Medical University

Tertychnyi A.S.

I.M. Sechenov First Moscow State Medical University (Sechenov University) of the Ministry of Health of Russia

Radenska-Lopovok S.G.

I.M. Sechenov First Moscow State Medical University

Zairatyants O.V.

Research Institute of Human Morphology;
Moscow State Medical and Dental University named after A.I. Evdokimov

Selivanova L.S.

National Medical Research Center of Endocrinology of the Ministry of Health of Russia

Received:

16.08.2021

Accepted:

17.09.2021

List of references:

  1. Choi EK, Appelman HD. Chronic Colitis in Biopsy Samples: Is It Inflammatory Bowel Disease or Something Else? Surg Pathol Clin. 2017;10(4):841-861.  https://doi.org/10.1016/j.path.2017.07.005
  2. Bressenot A, Cahn V, Danese S, Peyrin-Biroulet L. Microscopic features of colorectal neoplasia in inflammatory bowel diseases. World J Gastroenterol. 2014;20(12):3164-3172. https://doi.org/10.3748/wjg.v20.i12.3164
  3. Svrcek M, BorralhoNunes P, Villanacci V, et al. Clinicopathological and Molecular Specificities of Inflammatory Bowel Disease-Related Colorectal Neoplastic Lesions: The Role of Inflammation. J Crohns Colitis. 2018;12(12):1486-1498. https://doi.org/10.1093/ecco-jcc/jjy132
  4. Matkowskyj KA, Chen ZE, Rao MS, Yang GY. Dysplastic lesions in inflammatory bowel disease: molecular pathogenesis to morphology. Arch Pathol Lab Med. 2013;137(3):338-350.  https://doi.org/10.5858/arpa.2012-0086-RA
  5. Hnatyszyn A, Hryhorowicz S, Kaczmarek-Ryś M, et al. Colorectal carcinoma in the course of inflammatory bowel diseases. Hered Cancer ClinPract. 2019;17:18. Published 2019 Jul 12.  https://doi.org/10.1186/s13053-019-0118-4
  6. Eluri S, Parian AM, Limketkai BN, et al. Nearly a Third of High-Grade Dysplasia and Colorectal Cancer Is Undetected in Patients with Inflammatory Bowel Disease. Dig Dis Sci. 2017;62(12):3586-3593. https://doi.org/10.1007/s10620-017-4652-5
  7. Rugge M, Genta RM. Staging and grading of chronic gastritis. Hum Pathol. 2005;36(3):228-233.  https://doi.org/10.1016/j.humpath.2004.12.008
  8. Mosli MH, Feagan BG, Sandborn WJ, et al. Histologic evaluation of ulcerative colitis: A systematic review of disease activity indices. Inflamm Bowel Dis. 2014;20(3):564-575.  https://doi.org/10.1097/01.MIB.0000437986.00190.71
  9. Geboes K, Riddell R, Ost A, Jensfelt B, Persson T, Löfberg R. A reproducible grading scale for histological assessment of inflammation in ulcerative colitis. Gut. 2000;47(3):404-409.  https://www.ncbi.nlm.nih.gov/pubmed/10940279%5Cnhttps://www.ncbi.nlm.nih.gov/pubmed/10940279
  10. Jessurun J. The Differential Diagnosis of Acute Colitis: Clues to a Specific Diagnosis. Surg Pathol Clin. 2017;10(4):863-885.  https://doi.org/10.1016/j.path.2017.07.008
  11. Lai KK, Horvath B, Xie H, et al. Risk for colorectal neoplasia in patients with inflammatory bowel disease and mucosa indefinite for dysplasia. Inflamm Bowel Dis. 2015;21(2):378-384.  https://doi.org/10.1097/MIB.0000000000000286

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