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Akhrieva Kh.M.

Ingush State University

Kogan E.A.

Sechenov First Moscow State Medical University

Tertychnyi A.S.

I.M. Sechenov First Moscow State Medical University (Sechenov University) of the Ministry of Health of Russia

Radenska-Lopovok S.G.

I.M. Sechenov First Moscow State Medical University

Zairatyants O.V.

Research Institute of Human Morphology;
Moscow State Medical and Dental University named after A.I. Evdokimov

Selivanova L.S.

National Medical Research Center of Endocrinology of the Ministry of Health of Russia

A new look at colonic mucosal structural rearrangement and the stages of chronic colitis

Authors:

Akhrieva Kh.M., Kogan E.A., Tertychnyi A.S., Radenska-Lopovok S.G., Zairatyants O.V., Selivanova L.S.

More about the authors

Journal: Russian Journal of Archive of Pathology. 2021;83(6): 14‑19

DOI: 10.17116/patol20218306114

Read: 8306 times

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Table of contents

A NEW LOOK AT COLONIC MUCOSAL STRUCTURAL REARRANGEMENT AND THE STAGES OF CHRONIC COLITIS
A NEW LOOK AT COLONIC MUCOSAL STRUCTURAL REARRANGEMENT AND THE STAGES OF CHRONIC COLITIS

To cite this article:

Akhrieva KhM, Kogan EA, Tertychnyi AS, Radenska-Lopovok SG, Zairatyants OV, Selivanova LS. A new look at colonic mucosal structural rearrangement and the stages of chronic colitis. Russian Journal of Archive of Pathology. 2021;83(6):14‑19. (In Russ.)
https://doi.org/10.17116/patol20218306114

Подписка 2026 Архив патологии (Russian Journal of Archive of Pathology)
МСФ на ЯМ
Использование инфографики авторами научных работ
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Abstract:

OBJECTIVE

To revise the existing criteria to improve the definition of chronic colitis stages in inflammatory bowel diseases (IBDs).

MATERIAL AND METHODS

A total of 100 cases of IBDs (ulcerative colitis (n=70) and Crohn’s disease (n=30) diagnosed in 2017 to 2019 were examined. Thirty patients with colitis were selected for a comparison group, who were assigned to an infective colitis group or a drug-induced colitis one at the final diagnosis.

RESULTS

The sequence of chronic colitis stages was defined from Stage 1 (early changes) to Stage 3, which are characterized by progressive mucosal structural rearrangement. Mainly at Stage 3 that characterizes the final stage of structural rearrangement in the mucous membrane, where dysplastic changes (the onset of tumor transformation) are detected.

CONCLUSION

For the diagnosis of chronic colitis in IBD, it is mandatory to detect mucosal structural rearrangement. Stages 1 and 2 are characterized by early structural changes in the mucous membrane, whereas the process becomes irreversible at Stage 3. The identification of colitis stages is of diagnostic and, undoubtedly, prognostic value.

Keywords:

inflammatory bowel disease
chronic colitis
staging

Authors:

Akhrieva Kh.M.

Ingush State University

Kogan E.A.

Sechenov First Moscow State Medical University

Tertychnyi A.S.

I.M. Sechenov First Moscow State Medical University (Sechenov University) of the Ministry of Health of Russia

Radenska-Lopovok S.G.

I.M. Sechenov First Moscow State Medical University

Zairatyants O.V.

Research Institute of Human Morphology;
Moscow State Medical and Dental University named after A.I. Evdokimov

Selivanova L.S.

National Medical Research Center of Endocrinology of the Ministry of Health of Russia

Received:

16.08.2021

Accepted:

17.09.2021

Close metadata

References:

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