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Frank G.A.

Moskovskiĭ nauchno-issledovatel'skiĭ onkologicheskiĭ institut im. P.A. Gertsena Rosmedtekhnologiĭ, Moskva

Zavalishina L.É.

FGBU "Moskovskiĭ nauchno-issledovatel'skiĭ onkologicheskiĭ institut im. P.A. Gertsena" Minzdravsotsrazvitiia Rossii

Kekeeva T.V.

FGBU "Moskovskiĭ nauchno-issledovatel'skiĭ onkologicheskiĭ institut im. P.A. Gertsena" Minzdrava Rossii

Aleksakhina C.N.

FGBU "Nauchno- issledovatel'skiĭ institut onkologii im. N.N. Petrova" Minzdrava Rossii, Sankt-Peterburg

Garifullina T.R.

FGBU "Nauchno- issledovatel'skiĭ institut onkologii im. N.N. Petrova" Minzdrava Rossii, Sankt-Peterburg

Ivantsov O.A.

FGBU "Nauchno- issledovatel'skiĭ institut onkologii im. N.N. Petrova" Minzdrava Rossii, Sankt-Peterburg

Mitiushkina N.V.

FGBU "Nauchno- issledovatel'skiĭ institut onkologii im. N.N. Petrova" Minzdrava Rossii, Sankt-Peterburg

Pfaĭfer V.

FGBU "Nauchno- issledovatel'skiĭ institut onkologii im. N.N. Petrova" Minzdrava Rossii, Sankt-Peterburg

Strelkova T.N.

FGBU "Nauchno- issledovatel'skiĭ institut onkologii im. N.N. Petrova" Minzdrava Rossii, Sankt-Peterburg

Imianitov E.N.

NII onkologii im. N.N. Petrova, Sankt-Peterburg

First Russian nationwide molecular epidemiological study for melanoma: results of BRAF mutation analysis

Authors:

Frank G.A., Zavalishina L.É., Kekeeva T.V., Aleksakhina C.N., Garifullina T.R., Ivantsov O.A., Mitiushkina N.V., Pfaĭfer V., Strelkova T.N., Imianitov E.N.

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Journal: Russian Journal of Archive of Pathology. 2014;76(3): 65‑73

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FIRST RUSSIAN NATIONWIDE MOLECULAR EPIDEMIOLOGICAL STUDY FOR MELANOMA: RESULTS OF BRAF MUTATION ANALYSIS
FIRST RUSSIAN NATIONWIDE MOLECULAR EPIDEMIOLOGICAL STUDY FOR MELANOMA: RESULTS OF BRAF MUTATION ANALYSIS

To cite this article:

Frank GA, Zavalishina LÉ, Kekeeva TV, et al. . First Russian nationwide molecular epidemiological study for melanoma: results of BRAF mutation analysis. Russian Journal of Archive of Pathology. 2014;76(3):65‑73. (In Russ.)

Подписка 2026 Архив патологии (Russian Journal of Archive of Pathology)
МСФ на ЯМ
Использование инфографики авторами научных работ
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Abstract:

This report presents the initial results of the first Russian molecular epidemiological study of melanoma. The investigation included 1035 patients with stage IIIB-IV melanoma residing in various regions of Russia. Sequencing of BRAF gene revealed mutation in 627 (60.6%) tumors; c.1799T>A (p.V600E) substitution was detected in 563 cases, and other mutations in 64 melanomas. Frequency of BRAF alterations was significantly higher in patients of younger age (< 50 years: 72.9%; 50 years: 57.1%; p=0.00003). 710 melanomas included in the study were located in sun non-exposed regions of the skin; this category of tumors was characterized by the highest occurrence of BRAF mutations (63.9%). In conclusion, more than a half of Russian patients with advanced melanoma are potential candidates for the treatment of kinase inhibitors of mutated BRAF.

Keywords:

melanoma
molecular genetic study
mutations in the BRAF gene
melanoma
molecular genetic study
mutations in the BRAF gene

Authors:

Frank G.A.

Moskovskiĭ nauchno-issledovatel'skiĭ onkologicheskiĭ institut im. P.A. Gertsena Rosmedtekhnologiĭ, Moskva

Zavalishina L.É.

FGBU "Moskovskiĭ nauchno-issledovatel'skiĭ onkologicheskiĭ institut im. P.A. Gertsena" Minzdravsotsrazvitiia Rossii

Kekeeva T.V.

FGBU "Moskovskiĭ nauchno-issledovatel'skiĭ onkologicheskiĭ institut im. P.A. Gertsena" Minzdrava Rossii

Aleksakhina C.N.

FGBU "Nauchno- issledovatel'skiĭ institut onkologii im. N.N. Petrova" Minzdrava Rossii, Sankt-Peterburg

Garifullina T.R.

FGBU "Nauchno- issledovatel'skiĭ institut onkologii im. N.N. Petrova" Minzdrava Rossii, Sankt-Peterburg

Ivantsov O.A.

FGBU "Nauchno- issledovatel'skiĭ institut onkologii im. N.N. Petrova" Minzdrava Rossii, Sankt-Peterburg

Mitiushkina N.V.

FGBU "Nauchno- issledovatel'skiĭ institut onkologii im. N.N. Petrova" Minzdrava Rossii, Sankt-Peterburg

Pfaĭfer V.

FGBU "Nauchno- issledovatel'skiĭ institut onkologii im. N.N. Petrova" Minzdrava Rossii, Sankt-Peterburg

Strelkova T.N.

FGBU "Nauchno- issledovatel'skiĭ institut onkologii im. N.N. Petrova" Minzdrava Rossii, Sankt-Peterburg

Imianitov E.N.

NII onkologii im. N.N. Petrova, Sankt-Peterburg

Close metadata

References:

  1. Globocan 2012. Available at: http://globocan.iarc.fr
  2. Curiel-Lewandrowski C., Chen S.C., Swetter S.M. Melanoma Prevention Working Group-Pigmented Skin Lesion Sub-Committee. Screening and prevention measures for melanoma: is there a survival advantage? Curr. Oncol. Rep. 2012; 14 (5): 458-67.
  3. Eggermont A., Spatz A., Robert C. Cutaneous melanoma. Lancet. 2014; 383 (9919): 816-27.
  4. Ingraffea A. Melanoma. Fac. Plast. Surg. Clin. North Am. 2013; 21 (1): 33-42.
  5. Little E.G., Eide M.J. Update on the current state of melanoma incidence. Dermatol. Clin. 2012; 30 (3): 355-61.
  6. Russak J., Rigel D. et al. Risk factors for the development of primary cutaneous melanoma. Dermatol. Clin. 2012; 30 (3): 363-8.
  7. http://www.cancerresearchuk.org/cancer-info/cancerstats/types/skin/incidence/#world.
  8. Balch C. et al. Final version of the American Joint Committee on Cancer staging system for cutaneous melanoma. J. Clin. Oncol. 2001; 19 (16): 3635-48.
  9. Trinh V.A. Current management of metastatic melanoma. Am. J. Health Syst. Pharm. 2008; 65 (24, Suppl. 9): S3-8.
  10. Davies H., Bignell G.R., Cox C. et al. Mutations of the BRAF gene in human cancer. Nature. 2002; 417 (6892): 949-54.
  11. Govindarajan B., Bai X., Cohen C. et al. Malignant transformation of melanocytes to melanoma by constitutive activation of mitogen-activated protein kinase kinase (MAPKK) signaling. J. Biol. Chem. 2003; 278: 9790-5.
  12. Schlaak M., Bajah A., Podewski T. et al. Assessment of clinical parameters associated with mutational status in metastatic malignant melanoma: a single-centre investigation of 144 patients. Br. J. Dermatol. 2013; 168: 708-16.
  13. Bauer J., Buttner P., Murali R. et al. BRAF mutations in cutaneous melanoma are independently associated with age, anatomic site of the primary tumor and the degree of solar elastosis at the primary tumor site. Pigment Cell Melanoma Res. 2011; 24: 345-51.
  14. Long G.V., Trefzer U., Davies M.A. et al. Dabrafenib in patients with Val600Glu or Val600Lys BRAF-mutant melanoma metastatic to the brain (BREAK-MB): a multicentre, open-label, phase 2 trial. Lancet Oncol. 2012; 13 (11): 1087-95.
  15. Ponti G., Pellacani G., Tomasi A. et al. The somatic affairs of BRAF: tailored therapies for advanced malignant melanoma and orphan non-V600E (V600R-M) mutations. J. Clin. Pathol. 2013; 6 (5): 441-5.
  16. Cheng S., Chu P., Hinshaw M. et al. Frequency of mutations associated with targeted therapy in malignant melanoma petients. J. Clin. Oncol. 2011; 29 (15, Suppl.): abstr. 8597.
  17. McArthur G.A., Chapman P., Robert C. et al. Safety and efficacy of vemurafenib in BRAF V600E and BRAF V600K mutation-positive melanoma (BRIM-3): extended follow-up of a phase 3, randomized, open-label study. Lancet Oncol. 2014; 15 (3): 323-32.
  18. Pratilas C., Solit D. Targeting the mitogen-activated protein kinase pathway: physiological feedback and drug response. Clin. Cancer Res. 2010; 16 (13): 3329-34.
  19. Halaban R., Shang W., Bacchiocchi A. et al. PLX4032, a selective BRAF kinase inhibitor, activates the ERK pathway and enhances cell migration and proliferation of BRAF melanoma cells. Pigment Cell Melanoma Res. 2010; 23: 190-200.
  20. Bucheit A.D., Syklawer E., Jakob J.A. et al. Clinical characteristics and outcomes with specific BRAF and NRAS mutations in patients with metastatic melanoma. Cancer. 2013; 119 (21): 3821-9.
  21. Ekedahl H., Cirenajwis H., Harbst K. et al. The clinical significance of BRAF and NRAS mutations in a clinic-based metastatic melanoma cohort. Br. J. Dermatol. 2013; 169 (5): 1049-55.
  22. Greaves W.O., Verma S., Patel K.P. et al. Frequency and spectrum of BRAF mutations in a retrospective, single-institution study of 1112 cases of melanoma. J. Mol. Diagn. 2013; 15 (2): 220-6.
  23. Lui W., Kelly J.W., Trivett M. et al. Distinct clinical and pathological features are associated with the BRAF (T1799A(V600E)) mutation in primary melanoma. J. Invest. Dermatol. 2007; 127 (4): 900-5. doi:10.1038/sj.jid.5700632
  24. Venesio T., Chiorino G., Balsamo A. et al. In melanocytic lesions the fraction of BRAF V600E alleles is associated with sun exposure but unrelated to ERK phosphorylation. Mod. Pathol. 2008; 21 (6): 716-26.
  25. Chang Y., Barrett J., Bihop D. et al. Sun exposure and melanoma risk at different latitudes: a pooled analysis of 5700 cases and 7216 controls. Int. J. Epidemiol. 2009; 38 (3): 814-30.
  26. Thomas N., Edminston S., Alexander A. et al. Number of nevi and early-life ambient UV exposure are associated with BRAF-mutant melanoma. Cancer Epidemiol. Biomarkers Prev. 2007; 16 (5): 991-7.
  27. Lee J., Choi J., Kim Y. Frequencies of BRAF and NRAS mutations are different in histological types and sites of origin of cutaneous melanoma: a meta-analysis. Br. J. Dermatol. 2011; 164: 776-84.
  28. Andersen V., Fensterle J., Ugurel S. et al. Immunogenicity of constitutively active V599EBRaf. Cancer Res. 2004; 64: 5456-60.
  29. Long G., Menzies A., Nagrial A. et al. Prognostic and clinicopathologic association of oncogenic BRAF in metastatic melanoma. J. Clin. Oncol. 2011, 29: 1239-46.
  30. Starz H., Moody J., Welzel J. et al. Melanomas of the head-and-neck skin with mutations BRAF-V600K or Braf-V600R define a melanoma subtype with particular clinical features. J. Clin. Oncol. 2013; 31 (Suppl.): abstr. 9098.
  31. Colombino M., Lissia A., Capone M. et al. Heterogeneous distribution of BRAF/NRAS mutations among Italian patients with advanced melanoma. J. Transl. Med. 2013; 11: 202.
  32. Houben R., Becker J., Kappel A. et al. Constitutive activation of the Ras-Raf signaling pathway in metastatic melanoma is associated with poor prognosis. J. Carcinog. 2004; 3 (1): 6.
  33. Edlundh-Rose E., Egyhazi S., Omholt K. et al. NRAS and BRAF mutations in melanoma tumors in relation to clinical cheracteristics: a study based on mutation screening by pyrosequensing. Melanoma Res. 2006; 16: 471-8.
  34. Ascierto P.A., Schadendorf D., Berking C. et al. MEK162 for patients with advanced melanoma harbouring NRAS or Val600 BRAF mutations: a non-randomized, open-label phase 2 study. Lancet Oncol. 2013; 14 (3): 249-56.
  35. Hodi F.S., Corless C.L., Giobbie-Hurder A. et al. Imatinib for melanomas harboring mutationally activated or amplified KIT arising on mucosal, acral, and chronically sun-damaged skin. J. Clin. Oncol. 2013; 31 (26): 3182-90.
  36. Wolchok J.D., Kluger H., Callahan M.K. et al. Nivolumab plus ipilimumab in advanced melanoma. N. Engl. J. Med. 2013; 369 (2): 122-33.
  37. Jang S., Atkins M.B. Which drug, and when, for patients with BRAF-mutant melanoma? Lancet Oncol. 2013; 14 (2): e60-9.
  38. Kaprin A.V., Starinskiy V.V., Petrova G.V., eds. Sostoyanie onkologicheskoy pomoshchi naseleniyu Rossii v 2012 g.[ [State of oncological care in Russia in 2012]. Moscow: "Herzen Moscow Research Institute of Oncology" Publ.; 2013.
  39. Yanus G.A., Belyaeva A.V., Ivantsov A.O. et al. Pattern of clinically relevant mutations in consecutive series of ussian colorectal cancer patients. Med. Oncol. 2013; 30 (3): 686.
  40. Platz A., Egyhazi S., Ringborg U., Hansson J. Human cutaneous melanoma; a review of NRAS and BRAF mutation frequencies in relation to histogenetic subclass and body site. Mol. Oncol. 2008; 1 (4): 395-405.
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