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Moskalenko R.A.

Medical Institute, Sumy State University, Ministry of Education and Science of Ukraine, Sumy, Ukraine

Korneva Yu.S.

Smolensk Regional Institute of Pathology, Smolensk, Russia;
Federal State Budgetary Educational Institution of Higher Education 'Smolensk State Medical University' of the Ministry of Healthcare of the Russian Federation, Smolensk, Russia

Role of adipose tissue in the development and progression of colorectal cancer

Authors:

Moskalenko R.A., Korneva Yu.S.

More about the authors

Journal: Russian Journal of Archive of Pathology. 2019;81(1): 52‑56

DOI: 10.17116/patol20198101152

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To cite this article:

Moskalenko RA, Korneva YuS. Role of adipose tissue in the development and progression of colorectal cancer. Russian Journal of Archive of Pathology. 2019;81(1):52‑56. (In Russ.)
https://doi.org/10.17116/patol20198101152

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The paper gives the current data available in the literature on the relationship and pathogenetic mechanisms of influence of adipose tissue on colorectal carcinogenesis. It considers the aspects of changes in adipose tissue and microenvironment of the tumor itself, including those under the influence of biologically active substances secreted by adipocytes; differences in subcutaneous and visceral fat and their importance in the development and progression of colorectal cancer (CRC), as well as the role of adipose tissue-derived stem cells. Understanding these mechanisms for adipose tissue influence on CRC will assist not only in preventing this disease, but also in searching for new therapeutic targets.

Keywords:

colorectal cancer
adipose tissue
visceral fat
adipose tissue-derived stem cells

Authors:

Moskalenko R.A.

Medical Institute, Sumy State University, Ministry of Education and Science of Ukraine, Sumy, Ukraine

Korneva Yu.S.

Smolensk Regional Institute of Pathology, Smolensk, Russia;
Federal State Budgetary Educational Institution of Higher Education 'Smolensk State Medical University' of the Ministry of Healthcare of the Russian Federation, Smolensk, Russia

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