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Semenova L.A.

Nasonova Research Institute of Rheumatology, Moscow, Russia

Radenska-Lopovok S.G.

FGBU "Nauchno-issledovatel'skiĭ institut revmatologii im. V.A. Nasonovoĭ" RAMN, Moskva

Burtseva S.A.

Central Research Institute of Tuberculosis, Moscow, Russia

Berezovskiĭ Iu.S.

FGBU "TsNIIT" RAMN

Lepekha L.N.

Central Research Institute of Tuberculosis, Moscow, Russia

Necrotizing sarcoid granulomatosis

Authors:

Semenova L.A., Radenska-Lopovok S.G., Burtseva S.A., Berezovskiĭ Iu.S., Lepekha L.N.

More about the authors

Journal: Russian Journal of Archive of Pathology. 2016;78(5): 45‑49

DOI: 10.17116/patol201678545-49

Views: 5782

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To cite this article:

Semenova LA, Radenska-Lopovok SG, Burtseva SA, Berezovskiĭ IuS, Lepekha LN. Necrotizing sarcoid granulomatosis. Russian Journal of Archive of Pathology. 2016;78(5):45‑49. (In Russ.)
https://doi.org/10.17116/patol201678545-49

Подписка 2025 (Russian Journal of Archive of Pathology)
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Necrotizing sarcoid granulomatosis (NSG) belongs to productive small-vessel vasculitis with the formation of sarcoid-like granulomas, which is accompanied by ischemic necrosis of varying degrees and duration. The disease involves the lung only. The clinical symptoms of the disease are nonspecific so the latter is detected rather rarely. The main diagnostic technique is morphological examination. Immune complex inflammation develops in the vessel walls with the formation of macrophage-histiocytic granulomas that do not contain epithelioid cells. The etiology and pathogenesis of NSG remain little studied. Its differential diagnosis is mainly presented with tuberculosis, sarcoidosis, and granulomatosis with polyangiitis.

Keywords:

necrotizing sarcoid granulomatosis
sarcoidosis
granulomatosis with polyangiitis
tuberculosis

Authors:

Semenova L.A.

Nasonova Research Institute of Rheumatology, Moscow, Russia

Radenska-Lopovok S.G.

FGBU "Nauchno-issledovatel'skiĭ institut revmatologii im. V.A. Nasonovoĭ" RAMN, Moskva

Burtseva S.A.

Central Research Institute of Tuberculosis, Moscow, Russia

Berezovskiĭ Iu.S.

FGBU "TsNIIT" RAMN

Lepekha L.N.

Central Research Institute of Tuberculosis, Moscow, Russia

List of references:

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  2. Dem'yanenko N, Lepekha L. A complex case of differential diagnosis of disseminated pulmonary tuberculosis and necrotizing sarcoid granulomatosis. Tuberkulez i bolezni legkikh. 2013;(1):53-59. ISSN 2075-1230 (In Russ.)
  3. Tomashefski JF Jr, Cagle PT, Farver CF, Armando E Fraire AE, eds. Dail and Hammar’s pulmonary pathology. 3rd ed. New York: Springer-Verlag; 2008;vol.1:1088-1138. doi:10.1007/978-0-387-72114-9
  4. Spiteri V, Gledlull A, Campbell D. Necrotizing sarcoid granulomatosis. Br J Dis Chest. 1987;81:70-75.  doi:10.1016/0007-0971(87)90110-0
  5. Liebow A. Pulmonary angiitis and granulomatosis. Am Rev Respir Dis. 1973;108:1-18.
  6. Necrotizing sarcoid granulomatosis. In: Zander D, Farver C, eds. Pulmonary pathology. Philadelphia, PA: Elsevier; 2008:144-148.
  7. Churg A, Carrington C, Gupta R. Necrotizing sarcoid granulomatosis. Chest. 1979;76(4):406-413.  doi:10.1016/0007-0971(87)90110-0
  8. Chittock D, Joseph M, Paterson N, McFadden R. Necrotizing sarcoid granulomatosis with pleural involvement. Clinical and radiographic features. Chest. 1994;106(3):672-676.  doi:10.4236/health.2011.38089
  9. Doss M, Araneta R, Fiel-Gan M, Edelheit B. Cranial nerve VI palsy as initial presentation of necrotizing sarcoid granulomatosis in a 14-year-old female: case report and literature review. Semin Arthritis Rheum. 2015;44(4):456-460.  doi:10.1016/j.semarthrit.2014.07.004
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  11. Heinrich D, Gordjiani N, Trusen A, Marx A, Hebestreit H. Necrotizing sarcoid granulomatosis: a rarity in childhold. Pediatr Pulmonol. 2003;35(5):407-412.  doi:10.1002/ppul.10242
  12. Poper H, Klemen H, Colby T, Churg F. Necrotizing sarcoid granulomatosis - is it different from nоdular sarcоidosis? Pneumologie. 2003;57(5):268-271.
  13. Hsiung TC, Kuo CH, Kuo HP. A rare case of the coexistence of latent tuberculosis and necrotizing sarcoid granulomatosis with atypical presentation. J Formos Med Assoc. 2014;113(9):662-66  doi:10.1016/J.JFMA.2012.05.015
  14. Solov'eva I, Batyrov F, Ponomarev A, Fedorov D. Pathological anatomy of tuberculosis and differential diagnosis of granulomatous diseases. [Patologicheskaya anatomiya tuberkuleza i differentsial'naya diagnostika granulematoznykh zabolevanii]. Moscow: MMA imeni I.M. Sechenova; 2005. ISBN-5-85941-215-0 (In Russ.)
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