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Sukhanov D.S.

Sankt-Peterburgskaia gosudarstvennaia meditsinskaia akademiia im. I.I. Mechnikova

Vinogradova T.I.

Sankt-Peterburgskiĭ nauchno-issledovatel'skiĭ institut ftiziopul'monologii

Zabolotnykh N.V.

Sankt-Peterburgskiĭ nauchno-issledovatel'skiĭ institut ftiziopul'monologii

Vasil'eva S.N.

Vitovskaia M.L.

Laboratoriia éksperimental'nogo tuberkuleza i novykh meditsinskikh tekhnologiĭ FGBU "Sankt-Peterburgskiĭ nauchno-issledovatel'skiĭ institut ftiziopul'monologii" Minzdravsotsrazvitiia Rossii

The hepatoprotective activity of remaxol and S-adenosyl-L-methionine for liver damage caused by reserve-series antituberculosis drugs

Authors:

Sukhanov D.S., Vinogradova T.I., Zabolotnykh N.V., Vasil'eva S.N., Vitovskaia M.L.

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Journal: Russian Journal of Archive of Pathology. 2013;75(2): 25‑29

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To cite this article:

Sukhanov DS, Vinogradova TI, Zabolotnykh NV, Vasil'eva SN, Vitovskaia ML. The hepatoprotective activity of remaxol and S-adenosyl-L-methionine for liver damage caused by reserve-series antituberculosis drugs. Russian Journal of Archive of Pathology. 2013;75(2):25‑29. (In Russ.)

Подписка 2025 (Russian Journal of Archive of Pathology)
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Experiments on male albino outbred rats investigated the hepatoprotective activity of remaxol and ademethionine in liver damage caused by reserve-series antituberculosis drugs. The test drugs had a mixed action, by reducing the degree of cytolytic and cholestatic syndromes. Remaxol and ademethionine assist in diminishing the degree of liver structural and functional impairments occurring with reserve-series antituberculosis drugs, by restoring the girder structure of lobes and decreasing the magnitude of dystrophic changes to stimulate reparative processes. Histological examination of liver tissue sections from rats receiving ademethionine revealed the enhanced activity of alterative processes in the liver.

Keywords:

remaxol
S-adenosyl-L-methionine
drug-induced liver damage
tuberculosis

Authors:

Sukhanov D.S.

Sankt-Peterburgskaia gosudarstvennaia meditsinskaia akademiia im. I.I. Mechnikova

Vinogradova T.I.

Sankt-Peterburgskiĭ nauchno-issledovatel'skiĭ institut ftiziopul'monologii

Zabolotnykh N.V.

Sankt-Peterburgskiĭ nauchno-issledovatel'skiĭ institut ftiziopul'monologii

Vasil'eva S.N.

Vitovskaia M.L.

Laboratoriia éksperimental'nogo tuberkuleza i novykh meditsinskikh tekhnologiĭ FGBU "Sankt-Peterburgskiĭ nauchno-issledovatel'skiĭ institut ftiziopul'monologii" Minzdravsotsrazvitiia Rossii

List of references:

  1. Vol'f S.B., Sukhanov D.S., Romantsov M.G. Medikamentoznye porazheniya pecheni pri polikhimioterapii tuberkuleza. Vestnik Sankt-Peterburgskoi gosudarstvennoi meditsinskoi akademii im. I.I. Mechnikova. 2009; 1: 172-6.
  2. Ivanova D.A. Nezhelatel'nye pobochnye reaktsii pri lechenii bol'nykh tuberkulezom. Tuberkulez i bolezni legkikh. 2011; 6: 60-9.
  3. Okovityi S.V., Sukhanov D.S., Petrov A.Yu., Romantsov M.G. Gepatotropnye sredstva: sovremennoe sostoyanie problemy. Terapevticheskii arkhiv. 2012; 84 (2): 62-8.
  4. Sukhanov D.S. Effektivnost' gepatoprotektornogo deistviya i otsenka riskov pri ispol'zovanii reamberina, remaksola i ademetionina u bol'nykh tuberkulezom organov dykhaniya s lekarstvennymi porazheniyami pecheni. Terapevticheskii arkhiv. 2012; 84 (11): 26-30.
  5. Banerzhi A. Meditsinskaya statistika ponyatnym yazykom. M.: Prakticheskaya meditsina; 2007.
  6. Sukhanov D.S., Vinogradova T.I., Zabolotnykh N.V., Kovalenko A.L., Vasil'eva S.N., Romantsov M.G. Sravnitel'noe izuchenie gepatoprotektivnogo deistviya remaksola, reamberina i ademetionina pri povrezhdenii pecheni protivotuberkuleznymi preparatami (eksperimental'noe issledovanie). Antibiotiki i khimioterapiya. 2011; 56 (1-2): 13-7.

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