The site of the Media Sphera Publishers contains materials intended solely for healthcare professionals.
By closing this message, you confirm that you are a certified medical professional or a student of a medical educational institution.

Login
EN
+7 (495) 482-4118
+7 (495) 482-4329
+8 800 250-18-12
  • (toll-free number for subscriptions)
    Mon-Fri from 10 a.m. to 6 p.m.

  • © 1998-2026
+7 (495) 482-43-29
EN
All journals
Journal
Year
Year
Search result: 0

Zhirkova E.A.

Sklifosovsky Research Institute for Emergency Care, Moscow, Russia

Spiridonova T.G.

Sklifosovsky Research Institute for Emergency Care, Moscow, Russia

Sachkov A.V.

Sklifosovsky Research Institute for Emergency Care, Moscow, Russia

Eliseenkova E.I.

Sklifosovsky Research Institute for Emergency Care, Moscow, Russia

Medvedev A.O.

Sklifosovsky Research Institute for Emergency Care, Moscow, Russia

Borisov I.G.

Sklifosovsky Research Institute for Emergency Care, Moscow, Russia

Klychnikova E.V.

Sklifosovsky Research Institute for Emergency Care, Moscow, Russia

Godkov M.A.

Sklifosovsky Research Institute for Emergency Care, Moscow, Russia

Rogal M.L.

Sklifosovsky Research Institute for Emergency Care, Moscow, Russia

Petrikov S.S.

Sklifosovsky Research Institute for Emergency Care, Moscow, Russia;
Russian University of Medicine, Moscow, Russia

Leukocyte and platelet count for predicting thermal injury outcomes in patients with RFI score 71—180

Authors:

Zhirkova E.A., Spiridonova T.G., Sachkov A.V., Eliseenkova E.I., Medvedev A.O., Borisov I.G., Klychnikova E.V., Godkov M.A., Rogal M.L., Petrikov S.S.

More about the authors

Journal: Russian Journal of Anesthesiology and Reanimatology. 2026;(2): 26‑31

DOI: 10.17116/anaesthesiology202602126

Read: 338 times

Contact the author
Table of contents

LEUKOCYTE AND PLATELET COUNT FOR PREDICTING THERMAL INJURY OUTCOMES IN PATIENTS WITH RFI SCORE 71—180
LEUKOCYTE AND PLATELET COUNT FOR PREDICTING THERMAL INJURY OUTCOMES IN PATIENTS WITH RFI SCORE 71—180

To cite this article:

Zhirkova EA, Spiridonova TG, Sachkov AV, et al. Leukocyte and platelet count for predicting thermal injury outcomes in patients with RFI score 71—180. Russian Journal of Anesthesiology and Reanimatology. 2026;(2):26‑31. (In Russ.)
https://doi.org/10.17116/anaesthesiology202602126

МСФ на ЯМ
Использование инфографики авторами научных работ
Recommended articles:
Electrical Injury in Pediatric Practice. Piro­gov Russian Journal of Surgery. 2025;(8):67-74
Evidence-based model for reha­bilitation quality mana­gement. Rege­nerative Biotechnologies, Preventive, Digi­tal and Predictive Medi­cine. 2026;(1):12-15
Chemical burns in children. Piro­gov Russian Journal of Surgery. 2026;(7):104-110
Abstract:

There are no algorithms for treating burn patients based on burn injury outcome prediction indices.

OBJECTIVE

To improve prognosis of burn injury outcomes in patients with a Revised Frank Index (RFI) score 71—180 by taking into account white blood cell (WBC) and platelet counts.

MATERIAL AND METHODS

The study included 104 ICU patients with skin burns. WBC and platelet counts were measured on the first day after injury. We compared WBC and platelet counts in patients with different outcomes. Their predictive ability was assessed using binary logistic regression analysis and classification tree analysis.

RESULTS

WBC and platelet counts on the first day were significantly lower in survivors. Binary logistic regression analysis suggested that WBC and platelet counts were associated with injury outcome. We developed the outcome prediction algorithm and determined prognostic WBC and platelet counts. The algorithm is as follows: leukocyte count is first assessed, and WBC count >25.1·109/L is unfavorable. In case of WBC count ≤25.1·109/L, platelet count is assessed. This value ≤396·109/L is favorable, while platelet count >396·109/L is unfavorable.

CONCLUSION

Original burn injury outcome prediction algorithm takes into account leukocyte and platelet count and enables predicting favorable outcomes in patients with RFI score 71—180 with 93% accuracy.

Keywords:

burns
injury outcome prediction
leukocytes
platelets
patient stratification
RFI

Authors:

Zhirkova E.A.

Sklifosovsky Research Institute for Emergency Care, Moscow, Russia

Spiridonova T.G.

Sklifosovsky Research Institute for Emergency Care, Moscow, Russia

Sachkov A.V.

Sklifosovsky Research Institute for Emergency Care, Moscow, Russia

Eliseenkova E.I.

Sklifosovsky Research Institute for Emergency Care, Moscow, Russia

Medvedev A.O.

Sklifosovsky Research Institute for Emergency Care, Moscow, Russia

Borisov I.G.

Sklifosovsky Research Institute for Emergency Care, Moscow, Russia

Klychnikova E.V.

Sklifosovsky Research Institute for Emergency Care, Moscow, Russia

Godkov M.A.

Sklifosovsky Research Institute for Emergency Care, Moscow, Russia

Rogal M.L.

Sklifosovsky Research Institute for Emergency Care, Moscow, Russia

Petrikov S.S.

Sklifosovsky Research Institute for Emergency Care, Moscow, Russia;
Russian University of Medicine, Moscow, Russia

Received:

28.04.2025

Accepted:

02.10.2025

Close metadata

References:

  1. Zhirkova EA, Spiridonova TG, Sachkov AV, Medvedev AO, Eliseenkova EI, Borisov IG, Rogal ML, Petrikov SS. Comparing the Indices predictive of the thermal injury outcome. Transplantologiya. 2024;16(1):64-73. (In Russ.). https://doi.org/10.23873/2074-0506-2024
  2. Zhirkova EA, Spiridonova TG, Sachkov AV, Sinyakova OG, Eliseenkova EI, Medvedev AO, Rogal ML, Petrikov SS. Risk stratification of mortality in patients with thermal injury based on the Revised Frank Index. Russian Journal of Anesthesiology and Reanimatology. 2024;(2):32-38. (In Russ.). https://doi.org/10.17116/anaesthesiology202402132
  3. Sen S, Hsei L, Tran N, Romanowski K, Palmieri T, Greenhalgh D, Cho K. Early clinical complete blood count changes in severe burn injuries. Burns. 2019;45(1):97-102.  https://doi.org/10.1016/j.burns.2018.09.004
  4. Zhirkova EA, Spiridonova TG, Sachkov AV, Rebrova OYu, Petrikov SS. Revision of the Frank Index for Predicting Death in Thermal Injury. Russian Sklifosovsky Journal “Emergency Medical Care”. 2023;12(2):224-229. (In Russ.). https://doi.org/10.23934/2223-9022-2023-12-2-224-229
  5. Ozhogi termicheskie i khimicheskie. Ozhogi solnechnye. Ozhogi dykhatelnykh putej. Natsional’nye klinicheskie rekomendatsii. M. 2024. (In Russ.). Accessed April 09, 2025. https://cr.minzdrav.gov.ru/preview-cr/687_3
  6. Trukhacheva NV. Matematicheskaya statistika v mediko-biologicheskikh issledovaniyakh s primeneniem paketa Statistica. M.: GEOTAR-Media; 2012. (In Russ.).
  7. Narkevich AN, Vinogradov KA, Grjibovski AM. Intelligent Data Analysis in Biomedical Research: Classification Trees. Ekologiya cheloveka. 2021; (3):54-64. (In Russ.). https://doi.org/10.33396/1728-0869-2021-3-54-64
  8. Yadgarov MYa, Berikashvili LB, Kadantseva KK, Kuzovlev AN, Perehodov SN, Likhvantsev VV. Multivariate analysis in clinical medicine. Russian Journal of Anesthesiology and Reanimatology. 2021;(5):64-70. (In Russ.). https://doi.org/10.17116/anaesthesiology202105164
  9. Radivilko AS, Grigor’ev EV, Shukevich DL, Plotnikov GP. Multiple organ failure: early diagnosis and prognosis. Russian Journal of Anesthesiology and Reanimatology. 2018;(6):15-21. (In Russ.). https://doi.org/10.17116/anaesthesiology201806115
  10. Gajbhiye AS, Meshram MM, Kathod AP. Platelet count as a prognostic indicator in burn septicemia. Indian Journal of Surgery. 2013;75(6):444-448.  https://doi.org/10.1007/s12262-012-0532-6
  11. Osuka A, Ishihara T, Shimizu K, Shintani A, Ogura H, Ueyama M. Natural kinetics of blood cells following major burn: Impact of early decreases in white blood cells and platelets as prognostic markers of mortality. Burns. 2019;45(8):1901-1907. https://doi.org/10.1016/j.burns.2019.07.014
  12. Hussien AIM, Elsaka DMM, Ammar MS, Elkashty SM. Role of platelet count in predicting outcomes in major burn patients. Menoufia Medical Journal. 2022;35(3):1600-1603.
  13. Khan AY, Waheed F, Rehan M, Arshad Z, Iqbal T, Waqar S, Waheed U. Hematological Trends in Severe Burn Patients: A Comprehensive Study for Prognosis and Clinical Insights. Journal of Burn Care and Research. 2024; 45(5):1315-1320. https://doi.org/10.1093/jbcr/irae057
  14. Park J, Kym D, Kim M, Cho YS, Hur J, Chun W, Yoon D, Yoon J. Pioneering predictions of AKI and AKIN severity in burn patients: a comprehensive CBC approach. Scientific Reports. 2024;14(1):675.  https://doi.org/10.1038/s41598-024-51253-x
  15. Ma QM, Tang WB, Li XJ, Chang F, Yin X, Chen ZH, Wu GH, Xia CD, Li XL, Wang DY, Chu ZG, Zhang Y, Wang L, Wu CL, Tong YL, Cui P, Guo GH, Zhu ZH, Huang SY, Chang L, Liu R, Liu YJ, Wang YS, Liu XB, Shen T, Zhu F. [Multicenter retrospect analysis of early clinical features and analysis of risk factors on prognosis of elderly patients with severe burns]. Zhonghua Shao Shang Yu Chuangclinical fe Mian Xiu Fu Za Zhi. 2024;40(3):249-257.  https://doi.org/10.3760/cma.j.cn501225-20230808-00042
  16. Kral JB, Schrottmaier WC, Salzmann M, Assinger A. Platelet Interaction with Innate Immune Cells. Transfusion Medicine and Hemotherapy. 2016; 43(2):78-88.  https://doi.org/10.1159/000444807
  17. Carter JV, Pan J, Rai SN, Galandiuk S. ROC-ing along: Evaluation and interpretation of receiver operating characteristic curves. Surgery. 2016;159(6): 1638-1645. https://doi.org/10.1016/j.surg.2015.12.029
Contact the author
Email
Message
The publishing house "Media Sphere" does not provide treatment services, does not give recommendations on contacting medical institutions and specific specialists, on the prescription of medicines and dietary supplements.

Email Confirmation

An email was sent to test@gmail.com with a confirmation link. Follow the link from the letter to complete the registration on the site.

Email Confirmation

Contact us
If you have any questions, complaints or suggestions, please use this feedback form.
Email
Message
The publishing house "Media Sphere" does not provide treatment services, does not give recommendations on contacting medical institutions and specific specialists, on the prescription of medicines and dietary supplements.
Submit Application

You can become an author of one of our magazines, send a request and we will consider it in during the day.

Name
Phone
E-mail
Message
Login
Registration
E-mail
Password
Forgot Password?

Log in to the site using your account in one of the services

Password recovery
E-mail
Login
Register

We use cооkies to improve the performance of the site. By staying on our site, you agree to the terms of use of cооkies. To view our Privacy and Cookie Policy, please. click here.