Особенности фармакодинамики и фармакокинетики противоотечного средства эсцина лизината

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Отек является типовым патологическим процессом, сопровождающим широкий ряд заболеваний и состояний. Коррекция отека необходима для нормализации перфузии и трофики ткани, предупреждения вторичных нарушений и осложнений, облегчения боли и улучшения общего состояния пациента. Настоящий обзор посвящен механизмам действия тритерпенового сапонина эсцина и его эффективности при отеках различного генеза и с разной локализацией. Эсцин ингибирует гидролитические ферменты, предупреждает индукцию молекул клеточной адгезии, снижает активность провоспалительных сигнальных путей, поддерживает целостность межклеточных контактов, а также защищает клетки эндотелия от повреждения и нарушения функции. Экспериментальными и клиническими исследованиями установлено наличие у эсцина дополнительного противовоспалительного, анальгетического и антиоксидантного эффекта.

Ключевые слова:

эсцин

эсцина лизинат

отек

противоотечные средства

эндотелиопротекторы

Авторы:

Приходько В.А.

ФГБОУ ВО «Санкт-Петербургский государственный химико-фармацевтический университет» Минздрава России

ORCID: 0000-0002-4690-1811

Оковитый С.В.

ФГБОУ ВО «Санкт-Петербургский государственный химико-фармацевтический университет» Минздрава России

ORCID: 0000-0003-4294-5531

Дата поступления:

08.05.2025

Дата принятия в печать:

09.06.2025

Список литературы:

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