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Prikhodko V.A.

Saint Petersburg State Chemical and Pharmaceutical University of the Ministry of Health of Russia

Okovityi S.V.

Saint Petersburg State Chemical and Pharmaceutical University of the Ministry of Health of Russia

Pharmacokinetic and pharmacodynamic aspects of the anti-edematous agent escin lysinate

Authors:

Prikhodko V.A., Okovityi S.V.

More about the authors

Journal: Russian Journal of Anesthesiology and Reanimatology. 2025;(4): 81‑86

DOI: 10.17116/anaesthesiology202504181

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Table of contents

PHARMACOKINETIC AND PHARMACODYNAMIC ASPECTS OF THE ANTI-EDEMATOUS AGENT ESCIN LYSINATE
PHARMACOKINETIC AND PHARMACODYNAMIC ASPECTS OF THE ANTI-EDEMATOUS AGENT ESCIN LYSINATE

To cite this article:

Prikhodko VA, Okovityi SV. Pharmacokinetic and pharmacodynamic aspects of the anti-edematous agent escin lysinate. Russian Journal of Anesthesiology and Reanimatology. 2025;(4):81‑86. (In Russ.)
https://doi.org/10.17116/anaesthesiology202504181

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Abstract:

Edema is a typical pathological process that complicates a wide spectrum of disorders and conditions. Edema management is necessary to restore normal tissue perfusion and nutrient supply, prevent secondary injury and complications, relieve pain, and improve patient overall well-being. This article reviews the mechanisms of anti-edematous activity of escin, a triterpene saponin, in edema of different origins and locations. Escin inhibits hydrolytics enzymes, prevents the induction of cell adhesion molecules, downregulates pro-inflammatory signaling pathways, supports intercellular junction integrity, ameliorates endothelial cell damage and dysfunction. Experimental and clinical studies have found escin to possess additional anti-inflammatory, analgesic, and antioxidant effects.

Keywords:

escin
escin lysinate
edema
anti-edematous agents
endothelium-protective agents

Authors:

Prikhodko V.A.

Saint Petersburg State Chemical and Pharmaceutical University of the Ministry of Health of Russia

Okovityi S.V.

Saint Petersburg State Chemical and Pharmaceutical University of the Ministry of Health of Russia

Received:

08.05.2025

Accepted:

09.06.2025

Conflict of Interest :

The article was prepared with the sponsorship support of Pharmactive Capital LLC.

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References:

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