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Pyatkov A.A.

Sechenov First Moscow State Medical University (Sechenov University)

Sergeev A.V.

Sechenov First Moscow State Medical University (Sechenov University)

Sokolov E.A.

Sechenov First Moscow State Medical University (Sechenov University)

Nurmeeva A.R.

Sechenov First Moscow State Medical University (Sechenov University)

Kononirova A.A.

Sechenov First Moscow State Medical University (Sechenov University);
Federal Center for Brain and Neurotechnology

Makarov S.A.

Center for Surgical Treatment of Obesity and Metabolic Disorders — St. George Hospital

Transcranial magnetic stimulation in visual snow syndrome and functional disorders of visual perception

Authors:

Pyatkov A.A., Sergeev A.V., Sokolov E.A., Nurmeeva A.R., Kononirova A.A., Makarov S.A.

More about the authors

Journal: Russian Journal of Pain. 2025;23(1): 46‑54

Read: 2129 times


To cite this article:

Pyatkov AA, Sergeev AV, Sokolov EA, Nurmeeva AR, Kononirova AA, Makarov SA. Transcranial magnetic stimulation in visual snow syndrome and functional disorders of visual perception. Russian Journal of Pain. 2025;23(1):46‑54. (In Russ.)
https://doi.org/10.17116/pain20252301146

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References:

  1. Headache Classification Committee of the International Headache Society. The International Classification of Headache Disorders 3rd edition. Cephalalgia. 2018;38:1-211.  https://doi.org/10.1177/0333102417738202
  2. Puledda F, Schankin C, Goadsby PJ. Visual snow syndrome: A clinical and phenotypical description of 1,100 cases. Neurology. 2020 Feb 11;94(6): e564-e574. https://doi.org/10.1212/WNL.0000000000008909
  3. Liu GT, Schatz NJ, Galetta SL, Volpe NJ, Skobieranda F, Kosmorsky GS. Persistent positive visual phenomena in migraine. Neurology. 1995;45: 664-668.  https://doi.org/10.1212/wnl.45.4.664
  4. Klein A, Schankin CJ. Visual snow syndrome, the spectrum of perceptual disorders, and migraine as a common risk factor: A narrative review. Headache. 2021 Oct;61(9):1306-1313. https://doi.org/10.1111/head.14213
  5. Schankin CJ, Maniyar FH, Sprenger T, Chou DE, Eller M, Goadsby PJ. The relation between migraine, typical migraine aura and “visual snow”. Headache. 2014 June;54(6):957-966.  https://doi.org/10.1111/head.12378
  6. Schankin CJ, Maniyar FH, Digre KB, Goadsby PJ. ‘Visual snow’ — a disorder distinct from persistent migraine aura. Brain. 2014 May;137(Pt 5): 1419-1428. https://doi.org/10.1093/brain/awu050
  7. Silva EM, Puledda F. Visual snow syndrome and migraine: a review. Eye (Lond). 2023 Aug;37(12):2374-2378. Epub 2023 Feb 14.  https://doi.org/10.1038/s41433-023-02435-w
  8. Fraser CL, Hepschke JL, Jenkins B, Prasad S. Migraine Aura: Pathophysiology, Mimics, and Treatment Options. Semin Neurol. 2019 Dec;39(6):739-748.  https://doi.org/10.1055/s-0039-1700525
  9. Traber GL, Piccirelli M, Michels L. Visual snow syndrome: a review on diagnosis, pathophysiology, and treatment. Curr Opin Neurol. 2020 Feb;33(1):74-78.  https://doi.org/10.1097/WCO.0000000000000768
  10. Shaidegger YuM, Klimenko TV. Persistiruyushchee rasstrojstvo vospriyatiya, vyzvannoe gallyutsinogenami (HPPD): obzor literatury. Voprosy narkologii. 2021;8(203):23-38. (In Russ.). https://doi.org/10.47877/0234-0623_2021_08_23
  11. Vis PJ, Goudriaan AE, Ter Meulen BC, Blom JD. On Perception and Consciousness in HPPD: A Systematic Review. Front Neurosci. 2021 Aug 11;15:675768. PMID: 34456666; PMCID: PMC8385145. https://doi.org/10.3389/fnins.2021.675768
  12. Hang C, Leishangthem L, Yan Y. Not All Cases of Visual Snows are Benign: Mimics of Visual Snow Syndrome. Neuropsychiatr Dis Treat. 2021 Nov 10;17:3293-300.  https://doi.org/10.2147/NDT.S338111
  13. Tuekprakhon A, Pawestri AR, Suvannaboon R, Thongyou K, Trinavarat A, Atchaneeyasakul LO. Rare Co-Occurrence of Visual Snow in a Female Carrier With RPGRORF15-Associated Retinal Disorder. Front Genet. 2021 Oct 01;12:728085. https://doi.org/10.3389/fgene.2021.728085
  14. Hamel CP. Cone rod dystrophies. Orphanet J Rare Dis. 2007 Feb 01;2:7.  https://doi.org/10.1186/1750-1172-2-7
  15. Behbehani R. Clinical approach to optic neuropathies. Clin Ophthalmol. 2007 Sept;1(3):233-246. PMID: 19668477; PMCID: PMC2701125.
  16. Minos E, Barry RJ, Southworth S, Folkard A, Murray PI, Duker JS, Keane PA, Denniston AK. Birdshot chorioretinopathy: current knowledge and new concepts in pathophysiology, diagnosis, monitoring and treatment. Orphanet J Rare Dis. 2016 May 12;11(1):61.  https://doi.org/10.1186/s13023-016-0429-8
  17. Duker JS, Kaiser PK, Binder S, de Smet MD, Gaudric A, Reichel E, Sadda SR, Sebag J, Spaide RF, Stalmans P. The International Vitreomacular Traction Study Group classification of vitreomacular adhesion, traction, and macular hole. Ophthalmology. 2013 Dec;120(12):2611-2619. https://doi.org/10.1016/j.ophtha.2013.07.042
  18. Gishti O, van den Nieuwenhof R, Verhoekx J, van Overdam K. Symptoms related to posterior vitreous detachment and the risk of developing retinal tears: a systematic review. Acta Ophthalmol. 2019 June;97(4):347-352.  https://doi.org/10.1111/aos.14012
  19. Michal M, Lüchtenberg M, Overbeck G, Fronius M. Gestörtevisuelle Wahrnehmungbeim Depersonalisations-Derealisationssyndrom [Visual distortions and depersonalization-de-realization syndrome]. Klinische Monatsblätter für Augenheilkunde. 2006;223(4):279-284. (In German). https://doi.org/10.1055/s-2005-858716
  20. Staab JP, Eckhardt-Henn A, Horii A, Jacob R, Strupp M, Brandt T, Bronstein A. Diagnostic criteria for persistent postural-perceptual dizziness (PPPD): Consensus document of the committee for the Classification of Vestibular Disorders of the Bárány Society. J Vestib Res. 2017;27(4):191-208. PMID: 29036855; PMCID: PMC9249299. https://doi.org/10.3233/VES-170622
  21. Diukova GM, Zamergrad MV, Golubev VL, Adilova SM, Makarov SA. Functional (psychogenic) vertigo. S.S. Korsakov Journal of Neurology and Psychiatry. 2017;117(6):91-98. (In Russ.). https://doi.org/10.17116/jnevro20171176191-98
  22. Kamaeva AS, Kiryanova EA, Tabeeva GR. The phenomenon of “visual snow”: clinical and pathophysiological correlations, differential diagnosis and treatment (literature review). Nevrologiya, neiropsikhiatriya, psikhosomatika = Neurology, Neuropsychiatry, Psychosomatics. 2023;15(5):65-71. (In Russ.). https://doi.org/10.14412/2074-2711-2023-5-65-71
  23. Catarci T. Occipital ischaemic stroke after visual snow phenomenon — a case report. Cephalalgia. 2021 June;41(7):871-874.  https://doi.org/10.1177/0333102420985444
  24. Puledda F, Villar-Martínez MD, Goadsby PJ. Case Report: Transformation of Visual Snow Syndrome From Episodic to Chronic Associated With Acute Cerebellar Infarct. Front Neurol. 2022 Feb 15;13:811490. https://doi.org/10.3389/fneur.2022.811490
  25. Virdee J, Mollan SP. Photopsia. Pract Neurol. 2020;20(5):415-419.  https://doi.org/10.1136/practneurol-2019-002460
  26. Eren O, Schankin CJ. Insights into pathophysiology and treatment of visual snow syndrome: A systematic review. Prog Brain Res. 2020;255:311-326.  https://doi.org/10.1016/bs.pbr.2020.05.020
  27. Grangeon L, Lange KS, Waliszewska-Prosół M, Onan D, Marschollek K, Wiels W, Mikulenka P, Farham F, Gollion C, Ducros A; European Headache Federation School of Advanced Studies (EHF-SAS). Genetics of migraine: where are we now? J Headache Pain. 2023 Feb 20;24(1):12.  https://doi.org/10.1186/s10194-023-01547-8
  28. Volcheck MM, Graham SM, Fleming KC, Mohabbat AB, Luedtke CA. Central sensitization, chronic pain, and other symptoms: Better understanding, better management. Cleve Clin J Med. 2023 Apr 03;90(4):245-254.  https://doi.org/10.3949/ccjm.90a.22019
  29. Puledda F, Ffytche D, Lythgoe DJ, O’Daly O, Schankin C, Williams SCR, Goadsby PJ. Insular and occipital changes in visual snow syndrome: a BOLD fMRI and MRS study. Ann Clin Transl Neurol. 2020 Mar;7(3):296-306.  https://doi.org/10.1002/acn3.50986
  30. Puledda F, O’Daly O, Schankin C, Ffytche D, Williams SC, Goadsby PJ. Disrupted connectivity within visual, attentional and salience networks in the visual snow syndrome. Hum Brain Mapp. 2021 May;42(7):2032-2044. https://doi.org/10.1002/hbm.25343
  31. Puledda F, Dipasquale O, Gooddy BJM, Karsan N, Bose R, Mehta MA, Williams SCR, Goadsby PJ. Abnormal Glutamatergic and Serotonergic Connectivity in Visual Snow Syndrome and Migraine with Aura. Ann Neurol. 2023 Nov;94(5):873-884.  https://doi.org/10.1002/ana.26745
  32. Aeschlimann SA, Klein A, Schankin CJ. Visual snow syndrome: recent advances in understanding the pathophysiology and potential treatment approaches. Curr Opin Neurol. 2024 June 01;37(3):283-288.  https://doi.org/10.1097/WCO.0000000000001258
  33. van Dongen RM, Waaijer LC, Onderwater GLJ, Ferrari MD, Terwindt GM. Treatment effects and comorbid diseases in 58 patients with visual snow. Neurology. 2019 July 23;93(4):e398-e403. Epub 2019 June 18. PMID: 31213497; PMCID: PMC6669936. https://doi.org/10.1212/WNL.0000000000007825
  34. Fekete R. Visual snow syndrome successfully treated with lamotrigine: case report. (P4.129). Neurology. 2018) Apr 10;90(15 Suppl):129.  https://doi.org/10.1212/WNL.90.15_supplement.P4.129
  35. Mehler DMA, Sokunbi MO, Habes I, Barawi K, Subramanian L, Range M, Evans J, Hood K, Lührs M, Keedwell P, Goebel R, Linden DEJ. Targeting the affective brain-a randomized controlled trial of real-time fMRI neurofeedback in patients with depression. Neuropsychopharmacology. 2018 Dec;43(13):2578-2585. Epub 2018 June 23. PMID: 29967368; PMCID: PMC6186421. https://doi.org/10.1038/s41386-018-0126-5
  36. Zhao Z, Yao S, Li K, Sindermann C, Zhou F, Zhao W, Li J, Lührs M, Goebel R, Kendrick KM, Becker B. Real-Time Functional Connectivity-Informed Neurofeedback of Amygdala-Frontal Pathways Reduces Anxiety. Psychother Psychosom. 2019;88(1):5-15. Epub 2019 Jan 30. PMID: 30699438. https://doi.org/10.1159/000496057
  37. Lefaucheur JP, Aleman A, Baeken C, Benninger DH, Brunelin J, Di Lazzaro V, Filipović SR, Grefkes C, Hasan A, Hummel FC, Jääskeläinen SK, Langguth B, Leocani L, Londero A, Nardone R, Nguyen JP, Nyffeler T, Oliveira-Maia AJ, Oliviero A, Padberg F, Palm U, Paulus W, Poulet E, Quartarone A, Rachid F, Rektorová I, Rossi S, Sahlsten H, Schecklmann M, Szekely D, Ziemann U. Evidence-based guidelines on the therapeutic use of repetitive transcranial magnetic stimulation (rTMS): An update (2014-2018). Clin Neurophysiol. 2020 Feb;131(2):474-528. Epub 2020 Jan 01. Erratum in: Clin Neurophysiol. 2020 May;131(5):1168-1169. PMID: 31901449. https://doi.org/10.1016/j.clinph.2019.11.002
  38. Misra UK, Kalita J, Tripathi G, Bhoi SK. Role of β endorphin in pain relief following high rate repetitive transcranial magnetic stimulation in migraine. Brain Stimul. 2017 May-June;10(3):618-623.  https://doi.org/10.1016/j.brs.2017.02.006
  39. Paillère-Martinot ML, Galinowski A, Plaze M, Andoh J, Bartrés-Faz D, Bellivier F, Lefaucheur JP, Rivière D, Gallarda T, Martinot JL, Artiges E. Active and placebo transcranial magnetic stimulation effects on external and internal auditory hallucinations of schizophrenia. Acta Psychiatr Scand. 2017 Mar;135(3):228-238.  https://doi.org/10.1111/acps.12680
  40. Klomjai W, Katz R, Lackmy-Vallée A. Basic principles of transcranial magnetic stimulation (TMS) and repetitive TMS (rTMS). Ann Phys Rehabil Med. 2015 Sep;58(4):208-213. Epub 2015 Aug 28. PMID: 26319963. https://doi.org/10.1016/j.rehab.2015.05.005
  41. Creton S, Boulanger G, Pereon T, Batail JM, Drapier D. Treatment of Hallucinogen-Persisting Perception Disorder: A case report on repetitive transcranial magnetic stimulation targeting the right temporoparietal junction. Brain Stimul. 2024 Jan-Feb;17(1):107-108. Epub 2024 Jan 05. PMID: 38185321. https://doi.org/10.1016/j.brs.2023.12.015
  42. Eichhammer P, Kleinjung T, Landgrebe M, Hajak G, Langguth B. TMS for treatment of chronic tinnitus: neurobiological effects. Prog Brain Res. 2007;166:369-375.  https://doi.org/10.1016/S0079-6123(07)66035-X
  43. Cacace AT, Hu J, Romero S, Xuan Y, Burkard RF, Tyler RS. Glutamate is down-regulated and tinnitus loudness-levels decreased following rTMS over auditory cortex of the left hemisphere: A prospective randomized single-blinded sham-controlled cross-over study. Hear Res. 2018 Feb;358:59-73.  https://doi.org/10.1016/j.heares.2017.10.017
  44. Lau CI, Chen WH, Walsh V. The visual system as target of non-invasive brain stimulation for migraine treatment: Current insights and future challenges. Prog Brain Res. 2020;255:207-247. Epub 2020 June 15. PMID: 33008507. https://doi.org/10.1016/bs.pbr.2020.05.018
  45. Brighina F, Piazza A, Daniele O, Fierro B. Modulation of visual cortical excitability in migraine with aura: effects of 1 Hz repetitive transcranial magnetic stimulation. Exp Brain Res. 2002 July;145(2):177-181.  https://doi.org/10.1007/s00221-002-1096-7
  46. Grey V, Klobusiakova P, Minks E. Can repetitive transcranial magnetic stimulation of the visual cortex ameliorate the state of patients with visual snow? Bratisl Med J. 2020;121:395-399.  https://doi.org/10.4149/BLL_2020_064
  47. Grande M, Lattanzio L, Buard I, McKendrick AM, Chan YM, Pelak VS. A Study Protocol for an Open-Label Feasibility Treatment Trial of Visual Snow Syndrome With Transcranial Magnetic Stimulation. Front Neurol. 2021 Sept 24;12:724081. https://doi.org/10.3389/fneur.2021.724081
  48. Klein A, Aeschlimann SA, Zubler F, Scutelnic A, Riederer F, Ertl M, Schankin CJ. Alterations of the alpha rhythm in visual snow syndrome: a case-control study. J Headache Pain. 2024 Apr 08;25(1):53. PMID: 38584260; PMCID: PMC11000394. https://doi.org/10.1186/s10194-024-01754-x
  49. Orrù G, Bertelloni D, Cesari V, Conversano C, Gemignani A. Targeting temporal parietal junction for assessing and treating disembodiment phenomena: a systematic review of TMS effect on depersonalization and derealization disorders (DPD) and body illusions. AIMS Neurosci. 2021;8(2):181-194.  https://doi.org/10.3934/Neuroscience.2021009
  50. Lev-Ran S, Feingold D, Goodman C, Lerner AG. Comparing triggers to visual disturbances among individuals with positive vs negative experiences of hallucinogenpersisting perception disorder (HPPD) following LSD use. Am J Addict. 2017;26(6): 568-571.  https://doi.org/10.1111/ajad.12577
  51. Jay EL, Nestler S, Sierra M, McClelland J, Kekic M, David AS. Ventrolateral prefrontal cortex repetitive transcranial magnetic stimulation in the treatment of depersonalization disorder: A consecutive case series. Psychiatry Res. 2016 June 30;240:118-122.  https://doi.org/10.1016/j.psychres.2016.04.027
  52. Karris BC, Capobianco M, Wei X, Ross L. Treatment of Depersonalization Disorder With Repetitive Transcranial Magnetic Stimulation. J Psychiatr Pract. 2017 Mar;23(2):141-144.  https://doi.org/10.1097/PRA.0000000000000215
  53. Eren OE, Ruscheweyh R, Rauschel V, Eggert T, Schankin CJ, Straube A. Magnetic Suppression of Perceptual Accuracy Is Not Reduced in Visual Snow Syndrome. Front Neurol. 2021 May 04;12:658857. https://doi.org/10.3389/fneur.2021.658857
  54. Vucic S, Stanley Chen KH, Kiernan MC, Hallett M, Benninger DH, Di Lazzaro V, Rossini PM, Benussi A, Berardelli A, Currà A, Krieg SM, Lefaucheur JP, Long Lo Y, Macdonell RA, Massimini M, Rosanova M, Picht T, Stinear CM, Paulus W, Ugawa Y, Ziemann U, Chen R. Clinical diagnostic utility of transcranial magnetic stimulation in neurological disorders. Updated report of an IFCN committee. Clin Neurophysiol. 2023 June;150:131-175.  https://doi.org/10.1016/j.clinph.2023.03.010
  55. Valente M, Lettieri C, Russo V, Janes F, Gigli GL. Clinical and Neurophysiological Effects of Botulinum Neurotoxin Type A in Chronic Migraine. Toxins (Basel). 2021 May 29;13(6):392.  https://doi.org/10.3390/toxins13060392
  56. Neverdahl JP, Omland PM, Uglem M, Engstrøm M, Sand T. Reduced motor cortical inhibition in migraine: A blinded transcranial magnetic stimulation study. Clin Neurophysiol. 2017 Dec;128(12):2411-2418. https://doi.org/10.1016/j.clinph.2017.08.032
  57. Marchetti E, Lise I, Galmonte A, Murena L, Manganotti P. Efficacy of a dual task protocol on neurophysiological and clinical outcomes in migraine: a randomized control trial. Neurol Sci. 2024 Aug;45(8):4015-4026. https://doi.org/10.1007/s10072-024-07611-8

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