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Omelchenko M.A.

Mental Health Research Centre

Migalina V.V.

Mental Health Research Centre

Kaleda V.G.

Mental Health Research Centre

Therapeutic targets of adolescent depression with attenuated symptoms of schizophrenia

Authors:

Omelchenko M.A., Migalina V.V., Kaleda V.G.

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Journal: S.S. Korsakov Journal of Neurology and Psychiatry. 2024;124(12): 69‑74

DOI: 10.17116/jnevro202412412169

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THERAPEUTIC TARGETS OF ADOLESCENT DEPRESSION WITH ATTENUATED SYMPTOMS OF SCHIZOPHRENIA
THERAPEUTIC TARGETS OF ADOLESCENT DEPRESSION WITH ATTENUATED SYMPTOMS OF SCHIZOPHRENIA

To cite this article:

Omelchenko MA, Migalina VV, Kaleda VG. Therapeutic targets of adolescent depression with attenuated symptoms of schizophrenia. S.S. Korsakov Journal of Neurology and Psychiatry. 2024;124(12):69‑74. (In Russ.)
https://doi.org/10.17116/jnevro202412412169

 
 
Подписка 2025-2 (S.S. Korsakov Journal of Neurology and Psychiatry)
 
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OBJECTIVE

Identification of therapeutic targets in the treatment of adolescent depression with attenuated symptoms of schizophrenia and assessment of the effectiveness of therapeutic interventions.

MATERIAL AND METHODS

One hundred and twenty-three patients (mean age 19.6±2.3 years) hospitalized in the clinic of the Mental Health Research Center for adolescent depression with non-psychotic mental disorders (ICD-10: F31, F32, F33, F34; F60; F21) were examined. Group 1 (44.7%, n=55) received only psychopharmacotherapy, Group 2 (24.4%, n=30) additionally received a course of repetitive transcranial magnetic stimulation (rTMS) therapy, Group 3 (13.0%, n=16) was administered to TMS, Group 4 (17.9%, n=22) received psychotherapy. Psychometric scales (HDRS SOPS CGI, SANS) were used. Statistical analysis was performed using Statistica 12 software.

RESULTS

The addition of additional non-drug treatment methods (brain feedback and TMS) did not lead to a reliable improvement in the results, and in some cases negative results were obtained. Psychotherapy conducted according to protocols, taking into account the clinical characteristics of patients, demonstrated a significantly higher treatment effectiveness (p<0.05).

CONCLUSION

Additional therapy targets for adolescent depression with attenuated symptoms of schizophrenia have been identified, including specific mild positive, negative symptoms, and disorganization symptoms, which, although not prominent, are fundamentally important in the effectiveness of treatment.

Keywords:

youth depression
attenuated symptoms of schizophrenia
psychopharmacotherapy
non-pharmacological treatment methods
rTMS
TMS
depression psychotherapy

Authors:

Omelchenko M.A.

Mental Health Research Centre

Migalina V.V.

Mental Health Research Centre

Kaleda V.G.

Mental Health Research Centre

Received:

21.06.2024

Accepted:

08.09.2024

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