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Torshin I.Yu.

Federal Research Center «Computer Science and Control»

Gromova O.A.

Federal Research Center «Computer Science and Control»

Neurological functions and synergism of vitamins B1, B6 and B12

Authors:

Torshin I.Yu., Gromova O.A.

More about the authors

Journal: Russian Journal of Pain. 2022;20(1): 56‑64

DOI: 10.17116/pain20222001156

Read: 61553 times

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Table of contents

NEUROLOGICAL FUNCTIONS AND SYNERGISM OF VITAMINS B1, B6 AND B12
NEUROLOGICAL FUNCTIONS AND SYNERGISM OF VITAMINS B1, B6 AND B12

To cite this article:

Torshin IYu, Gromova OA. Neurological functions and synergism of vitamins B1, B6 and B12. Russian Journal of Pain. 2022;20(1):56‑64. (In Russ.)
https://doi.org/10.17116/pain20222001156

 
Подписка 2025 Российский журнал боли (Russian Journal of Pain)
МСФ на ЯМ
Использование инфографики авторами научных работ
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Abstract:

Deficiencies of group B vitamins are associated with the formation of neurological pathology. The paper presents the results of a systematic analysis of 1670 publications on fundamental and clinical studies of the neurological effects of vitamins B1, B6, B12. The results of the studies of the neurological effects of individual vitamins are systematized, the main mechanisms of molecular synergism of vitamins and their participation in detoxification of the body, the importance of synergism B1+B6+B12 in the treatment of the consequences of alcohol intake, neurodegenerative pathology (including demyelination) and in pain therapy are considered.

Keywords:

thiamine
pyridoxine
cyanocobalamin
detoxification
demyelination
nociception

Authors:

Torshin I.Yu.

Federal Research Center «Computer Science and Control»

Gromova O.A.

Federal Research Center «Computer Science and Control»

Received:

04.11.2021

Accepted:

24.11.2021

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References:

  1. Torshin IYu, Gromova OA. Ekspertnyj analiz dannykh v molekulyarnoj farmakologii. 2012;748. (In Russ.).
  2. Gromova OA, Torshin IYu, Gusev EI. Sinergidnye nejroprotektornye effekty tiamina, piridoksina i tsianokobalamina v ramkakh proteoma cheloveka. Farmakokinetika i farmakodinamika. 2017;(1):40-51. (In Russ.).
  3. Torshin IYu, Rudakov KV. On the Procedures of Generation of Numerical Features Over Partitions of Sets of Objects in the Problem of Predicting Numerical Target Variables. Pattern Recognition and Image Analysis. 2019;29(4):654-667.  https://doi.org/10.1134/S1054661819040175
  4. Aleshin VA, Mkrtchyan GV, Bunik VI. Mechanisms of Non-coenzyme Action of Thiamine: Protein Targets and Medical Significance. Biochemistry (Mosc). 2019;84(8):829-850. PMID: 31522667. https://doi.org/10.1134/S0006297919080017
  5. Gromova OA, Rebrov VG. Vitaminy, makro- i mikroelementy. Obuchayushchie programmy RSTs instituta mikroelementov YuNESKO. M.: GEOTAR-Media; 2008;954. (In Russ.).
  6. Truong T, Hetzel F, Stiff KM, Husnain MG. Case of hypoactive delirium precipitated by thiamine deficiency. BMJ Case Rep. 2021;14(3):e239886. PMID: 33731408. https://doi.org/10.1136/bcr-2020-239886
  7. Liu D, Ke Z, Luo J. Thiamine Deficiency and Neurodegeneration: the Interplay Among Oxidative Stress, Endoplasmic Reticulum Stress, and Autophagy. Mol Neurobiol. 2017;54(7):5440-5448. Epub 2016 Sep 5. PMID: 27596507. https://doi.org/10.1007/s12035-016-0079-9
  8. Kattah JC. The Spectrum of Vestibular and Ocular Motor Abnormalities in Thiamine Deficiency. Curr Neurol Neurosci Rep. 2017;17(5):40. PMID: 28365885. https://doi.org/10.1007/s11910-017-0747-9
  9. Bowyer JF, Tranter KM, Sarkar S, Hanig JP. Microglial activation and vascular responses that are associated with early thalamic neurodegeneration resulting from thiamine deficiency. Neurotoxicology. 2018;65:98-110. PMID: 29427613. https://doi.org/10.1016/j.neuro.2018.02.005
  10. Ji Z, Fan Z, Zhang Y, Yu R, Yang H, Zhou C, Luo J, Ke ZJ. Thiamine deficiency promotes T cell infiltration in experimental autoimmune encephalomyelitis: the involvement of CCL2. J Immunol. 2014;193(5):2157-2167. PMID: 25063874. https://doi.org/10.4049/jimmunol.1302702
  11. Chauhan A, Srivastva N, Bubber P. Thiamine Deficiency Induced Dietary Disparity Promotes Oxidative Stress and Neurodegeneration. Indian J Clin Biochem. 2018;33(4):422-428. Epub 2017 Sept 01. PMID: 30319188. https://doi.org/10.1007/s12291-017-0690-1
  12. Liu H, Sang S, Lu Y, Wang Z, Yu X, Zhong C. Thiamine metabolism is critical for regulating correlated growth of dendrite arbors and neuronal somata. Sci Rep. 2017;7(1):5342. PMID: 28706281. https://doi.org/10.1038/s41598-017-05476-w
  13. Yu Q, Liu H, Sang S, Chen L, Zhao Y, Wang Y, Zhong C. Thiamine deficiency contributes to synapse and neural circuit defects. Biol Res. 2018;51(1):35. PMID: 30231926. https://doi.org/10.1186/s40659-018-0184-5
  14. Moreira-Lobo DC, Cruz JS, Silva FR, Ribeiro FM, Kushmerick C, Oliveira FA. Thiamine Deficiency Increases Ca2+ Current and CaV1.2 L-type Ca2+ Channel Levels in Cerebellum Granular Neurons. Cell Mol Neurobiol. 2017;37(3):453-460. Epub 2016 May 02. PMID: 27140189. https://doi.org/10.1007/s10571-016-0378-8
  15. Cruz JS, Kushmerick C, Moreira-Lobo DC, Oliveira FA. Thiamine deficiency in vitro accelerates A-type potassium current inactivation in cerebellar granule neurons. Neuroscience. 2012;221:108-114. PMID: 22771620. https://doi.org/10.1016/j.neuroscience.2012.06.053
  16. Ke ZJ, DeGiorgio LA, Volpe BT, Gibson GE. Reversal of thiamine deficiency-induced neurodegeneration. J Neuropathol Exp Neurol. 2003;62(2):195-207. PMID: 12578229. https://doi.org/10.1093/jnen/62.2.195
  17. Bolaños-Burgos IC, Bernal-Correa AM, Mahecha GAB, Ribeiro ÂM, Kushmerick C. Thiamine Deficiency Increases Intrinsic Excitability of Mouse Purkinje Cells. Cerebellum. 2021;20(2):186-202. PMID: 33098550. https://doi.org/10.1007/s12311-020-01202-x
  18. Ghatge MS, Al Mughram M, Omar AM, Safo MK. Inborn errors in the vitamin B6 salvage enzymes associated with neonatal epileptic encephalopathy and other pathologies. Biochimie. 2021;183:18-29. PMID: 33421502. https://doi.org/10.1016/j.biochi.2020.12.025
  19. Ramos RJ, Pras-Raves ML, Gerrits J, van der Ham M, Willemsen M, Prinsen H, Burgering B, Jans JJ, Verhoeven-Duif NM. Vitamin B6 is essential for serine de novo biosynthesis. J Inherit Metab Dis. 2017;40(6):883-891. PMID: 28801717. https://doi.org/10.1007/s10545-017-0061-3
  20. Claus D, Neundörfer B, Warecka K. The influence of vitamin B6 deficiency on somatosensory stimulus conduction in the rat. Eur Arch Psychiatry Neurol Sci. 1984;234(2):102-105. PMID: 6094193. https://doi.org/10.1007/BF00381215
  21. Rezazadeh A, Oveisgharan S, Shahidi G, Naghdi R. A Case Report of HomocystinuriaWith Dystonia and Stroke. Child Neurol Open. 2014;1(1):2329048X14545870. PMID: 28503581. https://doi.org/10.1177/2329048X14545870
  22. Nuru M, Muradashvili N, Kalani A, Lominadze D, Tyagi N. High methionine, low folate and low vitamin B6/B12 (HM-LF-LV) diet causes neurodegeneration and subsequent short-term memory loss. Metab Brain Dis. 2018;33(6):1923-1934. PMID: 30094804. https://doi.org/10.1007/s11011-018-0298-z
  23. Kirksey A, Morré DM, Wasynczuk AZ. Neuronal development in vitamin B6 deficiency. Ann N Y Acad Sci. 1990;585:202-218. PMID: 2356985. https://doi.org/10.1111/j.1749-6632.1990.tb28054.x
  24. Jung HY, Kim W, Hahn KR, Kang MS, Kim TH, Kwon HJ, Nam SM, Chung JY, Choi JH, Yoon YS, Kim DW, Yoo DY, Hwang IK. Pyridoxine Deficiency Exacerbates Neuronal Damage after Ischemia by Increasing Oxidative Stress and Reduces Proliferating Cells and Neuroblasts in the Gerbil Hippocampus. Int J Mol Sci. 2020;21(15):5551. PMID: 32759679. https://doi.org/10.3390/ijms21155551
  25. Cohen M, Bendich A. Safety of pyridoxine — A review of human and animal studies. Toxicology Letters. 1986;34:129-139. 
  26. Inada M, Toyoshima M, Kameyama M. Cobalamin contents of the brains in some clinical and pathologic states. Int J Vitam Nutr Res. 1982;52(4):423-429. PMID: 7160970.
  27. Güneş HN, Bekircan-Kurt CE, Tan E, Erdem-Özdamar S. The histopathological evaluation of small fiber neuropathy in patients with vitamin B12 deficiency. Acta Neurol Belg. 2018;118(3):405-410. Epub 2017 Oct 19. PMID: 29052170. https://doi.org/10.1007/s13760-017-0847-y
  28. Zhang A, Ackley BD, Yan D. Vitamin B12 Regulates Glial Migration and Synapse Formation through Isoform-Specific Control of PTP-3/LAR PRTP Expression. Cell Rep. 2020;30(12):3981-3988.e3. PMID: 32209461. https://doi.org/10.1016/j.celrep.2020.02.113
  29. Ayyildiz T, Dulkadiroglu R, Yilmaz M, Polat OA, Gunes A. Evaluation of macular, retinal nerve fiber layer and choroidal thickness by optical coherence tomography in children and adolescents with vitamin B12 deficiency. Int Ophthalmol. 2021;41(7):2399-2404. Epub 2021 Mar 25. PMID: 33768408. https://doi.org/10.1007/s10792-021-01794-1
  30. Carmel R. Efficacy and safety of fortification and supplementation with vitamin B12: biochemical and physiological effects. Food Nutr Bull. 2008;29(V2):S177-S187.
  31. Midttun O, Hustad S, Schneede J, Vollset SE, Ueland PM. Plasma vitamin B-6 forms and their relation to transsulfuration metabolites in a large, population-based study. Am J Clin Nutr. 2007;86(1):131-138. 
  32. Stakhovskaya LV, Gromova OA, Torshin IYu, Filimonova MV. Protivoopukholevye effekty sochetannogo primeneniya vitaminov V1, V6 i V12. Nevrologiya, nejropsikhiatriya, psikhosomatika. 2017;9(4):101-105. (In Russ.). https://doi.org/10.14412/2074-2711-2017-4-101-105
  33. Subramanya SB, Subramanian VS, Sekar VT, Said HM. Thiamin uptake by pancreatic acinar cells: effect of chronic alcohol feeding/exposure. Am J Physiol Gastrointest Liver Physiol. 2011;301(5):G896-904. Epub 2011 Aug 25. PMID: 21868632. https://doi.org/10.1152/ajpgi.00308.2011
  34. Dilrukshi MDSA, Ratnayake CAP, Gnanathasan CA. Oral pyridoxine can substitute for intravenous pyridoxine in managing patients with severe poisoning with isoniazid and rifampicin fixed dose combination tablets: A case report. BMC Res Notes. 2017;10(1):370. PMID: 28789699. https://doi.org/10.1186/s13104-017-2678-6
  35. Waly MI, Kharbanda KK, Deth RC. Ethanol lowers glutathione in rat liver and brain and inhibits methionine synthase in a cobalamin-dependent manner. Alcohol Clin Exp Res. 2011;35(2):277-283. Epub 2010 Dec 1. PMID: 21121936. https://doi.org/10.1111/j.1530-0277.2010.01343.x
  36. Xu Y, Li L, Zhang Z, Li Y. Effects of folinic acid and Vitamin B12 on ethanol-induced developmental toxicity in mouse. Toxicol Lett. 2006;167(3):167-172. Epub 2006 Sept 17. PMID: 17052868. https://doi.org/10.1016/j.toxlet.2006.07.341
  37. Usov KI, Yushkov GG, Mashanov AV. Ostraya toksichnost’ protivotuberkuleznykh preparatov, soderzhashchikh i ne soderzhashchikh piridoksina gidrokhlorid (eksperimental’noe issledovanie). Tuberkulez i bolezni legkikh. 2014;(12):76-82. (In Russ.).
  38. Federal’nye klinicheskie rekomendatsii po diagnostike i lecheniyu abstinentnogo sostoyaniya s deliriem, vyzvannogo upotrebleniem psikhoaktivnykh veshchestv. Rossijskoe obshchestvo psikhiatrov. Iyul’ 2014. (In Russ.). Accessed July 27, 2021. https://psychiatr.ru/download/1680
  39. Gofman AG. Lechenie bol’nykh alkogol’nymi psikhozami. Russkij meditsinskij zhurnal. 2002;12:556-566. (In Russ.).
  40. Chornyy S, Parkhomenko Y, Chorna N. Thiamine antagonists trigger p53-dependent apoptosis in differentiated SH-SY5Y cells. Sci Rep. 2017;7(1):10632. PMID: 28878400. https://doi.org/10.1038/s41598-017-10878-x
  41. Chornyy S, Parkhomenko J, Chorna N. Thiamine deficiency caused by thiamine antagonists triggers upregulation of apoptosis inducing factor gene expression and leads to caspase 3-mediated apoptosis in neuronally differentiated rat PC-12 cells. Acta Biochim Pol. 2007;54(2):315-22. PMID: 17502925 
  42. Wang X, Xu M, Frank JA, Ke ZJ, Luo J. Thiamine deficiency induces endoplasmic reticulum stress and oxidative stress in human neurons derived from induced pluripotent stem cells. Toxicol Appl Pharmacol. 2017;320:26-31. PMID: 28193519. https://doi.org/10.1016/j.taap.2017.02.009
  43. Nakagawasai O. Behavioral and neurochemical alterations following thiamine deficiency in rodents: relationship to functions of cholinergic neurons. Yakugaku Zasshi. 2005;125(7):549-54. PMID: 15997211. https://doi.org/10.1248/yakushi.125.549
  44. Hamada S, Hirashima H, Imaeda M, Okamoto Y, Hamaguchi-Hamada K, Kurumata-Shigeto M. Thiamine deficiency induces massive cell death in the olfactory bulbs of mice. J Neuropathol Exp Neurol. 2013;72(12):1193-1202. PMID: 24226264. https://doi.org/10.1097/NEN.0000000000000017
  45. Zera K, Zastre J. Thiamine deficiency activates hypoxia inducible factor-1α to facilitate pro-apoptotic responses in mouse primary astrocytes. PLoS One. 2017;12(10):e0186707. eCollection 2017. PMID: 29045486. https://doi.org/10.1371/journal.pone.0186707
  46. Danielyan KE, Simonyan AA. Protective abilities of pyridoxine in experimental oxidative stress settings in vivo and in vitro. Biomed Pharmacother. 2017;86:537-540. Epub 2016 Dec 23. PMID: 28024289. https://doi.org/10.1016/j.biopha.2016.12.053
  47. Wu F, Xu K, Liu L, Zhang K, Xia L, Zhang M, Teng C, Tong H, He Y, Xue Y, Zhang H, Chen D, Hu A. Vitamin B12 Enhances Nerve Repair and Improves Functional Recovery After Traumatic Brain Injury by Inhibiting ER Stress-Induced Neuron Injury. Front Pharmacol. 2019;10:406. eCollection 2019. PMID: 31105562. https://doi.org/10.3389/fphar.2019.00406
  48. Li EY, Zhao PJ, Jian J, Yin BQ, Sun ZY, Xu CX, Tang YC, Wu H. Vitamin B1 and B12 mitigates neuron apoptosis in cerebral palsy by augmenting BDNF expression through MALAT1/miR-1 axis. Cell Cycle. 2019;18(21):2849-2859. PMID: 31500509. https://doi.org/10.1080/15384101.2019.1638190
  49. Okamoto M, Tanaka H, Okada K, Kuroda Y, Nishimoto S, Murase T, Yoshikawa H. Methylcobalamin promotes proliferation and migration and inhibits apoptosis of C2C12 cells via the Erk1/2 signaling pathway. Biochem Biophys Res Commun. 2014;443(3):871-875. Epub 2013 Dec 14. PMID: 24342621. https://doi.org/10.1016/j.bbrc.2013.12.056
  50. Inaba H, Kishimoto T, Oishi S, Nagata K, Hasegawa S, Watanabe T, Kida S. Vitamin B1-deficient mice show impairment of hippocampus-dependent memory formation and loss of hippocampal neurons and dendritic spines: potential microendophenotypes of Wernicke-Korsakoff syndrome. Biosci Biotechnol Biochem. 2016;80(12):2425-2436. Epub 2016 Aug 31. PMID: 27576603. https://doi.org/10.1080/09168451.2016.1224639
  51. Okada K, Tanaka H, Temporin K, Okamoto M, Kuroda Y, Moritomo H, Murase T, Yoshikawa H. Akt/mammalian target of rapamycin signaling pathway regulates neurite outgrowth in cerebellar granule neurons stimulated by methylcobalamin. Neurosci Lett. 2011;495(3):201-204. Epub 2011 Mar 30. PMID: 21458538. https://doi.org/10.1016/j.neulet.2011.03.065
  52. Rathod RS, Khaire AA, Kale AA, Joshi SR. Effect of vitamin B12 and omega-3 fatty acid supplementation on brain neurotrophins and cognition in rats: A multigeneration study. Biochimie. 2016;128-129:201-208. Epub 2016 Aug 26. PMID: 27569259. https://doi.org/10.1016/j.biochi.2016.08.009
  53. Becker KW, Kienecker EW, Dick P. A contribution to the scientific assessment of degenerative and regenerative processes of peripheral nerve fibers following axonotmesis under the systemic administration of vitamins B1, B6 and B12 — light and electron microscopy findings of the saphenous nerve of the rabbit. Minim Invasive Neurosurg. 1990;33(4):113-121. PMID: 2395502. https://doi.org/10.1055/s-2008-1053569
  54. Ishibashi S, Yokota T, Shiojiri T, Matunaga T, Tanaka H, Nishina K, Hirota H, Inaba A, Yamada M, Kanda T, Mizusawa H. Reversible acute axonal polyneuropathy associated with Wernicke-Korsakoff syndrome: impaired physiological nerve conduction due to thiamine deficiency? J Neurol Neurosurg Psychiatry. 2003;74(5):674-676. PMID: 12700319. https://doi.org/10.1136/jnnp.74.5.674
  55. Knowles JF. An electron microscope study of the unmyelinated nerve fibres in normal baboon median nerves: negative effect of vitamin-B12 depletion. J Anat. 1976;121(Pt 3):461-474. PMID: 828156.
  56. Gromova OA, Torshin IYu, Chuchalin AG. On the prospects for the use of thiamine, pyridoxine, and cyanocobalamin in the complex therapy and rehabilitation of patients with COVID-19. Pulmonologiya. 2021;31(3):355-363. (In Russ.). https://doi.org/10.18093/0869-0189-2021-31-3-355-363
  57. Brito A, Verdugo R, Hertrampf E, Miller JW, Green R, Fedosov SN, Shahab-Ferdows S, Sanchez H, Albala C, Castillo JL, Matamala JM, Uauy R, Allen LH. Vitamin B-12 treatment of asymptomatic, deficient, elderly Chileans improves conductivity in myelinated peripheral nerves, but high serum folate impairs vitamin B-12 status response assessed by the combined indicator of vitamin B-12 status. Am J Clin Nutr. 2016;103(1):250-257. Epub 2015 Nov 25. PMID: 26607937. https://doi.org/10.3945/ajcn.115.116509
  58. Zhang K, Pei Y, Gan Z, Zhang X, Duan Y, Liu Y, Liu W. Local Administration of Thiamine Ameliorates Ongoing Pain in a Rat Model of Second-Degree Burn. J Burn Care Res. 2017;38(5):842-850. PMID: 28181986. https://doi.org/10.1097/BCR.0000000000000502
  59. Antonio C, Massimo T, Gianpaolo Z, Immacolata PM, Erika T. Oral High-Dose Thiamine Improves the Symptoms of Chronic Cluster Headache. Case Rep Neurol Med. 2018;2018:3901619. eCollection 2018. PMID: 29850313. https://doi.org/10.1155/2018/3901619
  60. North RA, Jarvis MF. P2X receptors as drug targets. Mol Pharmacol. 2013;83(4):759-769. Epub 2012 Dec 19. PMID: 23253448. https://doi.org/10.1124/mol.112.083758
  61. Lämmer AB, Beck A, Grummich B, Förschler A, Krügel T, Kahn T, Schneider D, Illes P, Franke H, Krügel U. The P2 receptor antagonist PPADS supports recovery from experimental stroke in vivo. PLoS One. 2011;6(5):e19983. Epub 2011 May 17. PMID: 21611146. https://doi.org/10.1371/journal.pone.0019983
  62. Wang X, Arcuino G, Takano T, Lin J, Peng WG, Wan P, Li P, Xu Q, Liu QS, Goldman SA, Nedergaard M. P2X7 receptor inhibition improves recovery after spinal cord injury. Nat Med. 2004;10(8):821-827. Epub 2004 July 18. PMID: 15258577. https://doi.org/10.1038/nm1082
  63. Thériault O, Poulin H, Thomas GR, Friesen AD, Al-Shaqha WA, Chahine M. Pyridoxal-5’-phosphate (MC-1), a vitamin B6 derivative, inhibits expressed P2X receptors. Can J Physiol Pharmacol. 2014;92(3):189-96. PMID: 24593783. https://doi.org/10.1139/cjpp-2013-0404
  64. Xu J, Wang W, Zhong XX, Feng Y, Wei X, Liu XG. EXPRESS: Methylcobalamin ameliorates neuropathic pain induced by vincristine in rats: Effect on loss of peripheral nerve fibers and imbalance of cytokines in the spinal dorsal horn. Mol Pain. 2016;12:1744806916657089. PMID: 27306413. https://doi.org/10.1177/1744806916657089
  65. Gromova OA, Torshin IYu, Putilina MV, Maiorova LA, Semenov VA. On the mechanisms of the synergistic action of tolperisone, meloxicam and B vitamins in the treatment of peripheral pain syndromes. Medical Council. 2020;(8):54-64. (In Russ.). https://doi.org/10.21518/2079-701X-2020-8-54-64
  66. Gromova OA, Torshin IYu, Maiorova LA, Koifman OI, Salnikov DS. Bioinformatic and chemoneurocytological analysis of the pharmacological properties of vitamin B12 and some of its derivatives. Journal of Porphyrins and Phthalocyanines. 2021;25(09):835-842.  https://doi.org/10.1142/S1088424621500644
  67. Mauro GL, Martorana U, Cataldo P, Brancato G, Letizia G. Vitamin B12 in low back pain: A randomised, double-blind, placebo-controlled study. Eur Rev Med Pharmacol Sci. 2000;4(3):53-58. 
  68. Wang ZB, Gan Q, Rupert RL, Zeng YM, Song XJ. Thiamine, pyridoxine, cyanocobalamin and their combination inhibit thermal, but not mechanical hyperalgesia in rats with primary sensory neuron injury. Pain. 2005;114(1-2):266-277. PMID: 15733653. https://doi.org/10.1016/j.pain.2004.12.027
  69. Jurna I, Carlsson KH, Kömen W, Bonke D. Acute effects of vitamin B6 and fixed combinations of vitamin B1, B6 and B12 on nociceptive activity evoked in the rat thalamus: dose-response relationship and combinations with morphine and paracetamol. Klin Wochenschr. 1990;68(2):129-135. PMID: 2157085. https://doi.org/10.1007/BF01646861
  70. Zaringhalam J, Akbari A, Zali A, Manaheji H, Nazemian V, Shadnoush M, Ezzatpanah S. Long-Term Treatment by Vitamin B1 and Reduction of Serum Proinflammatory Cytokines, Hyperalgesia, and Paw Edema in Adjuvant-Induced Arthritis. Basic Clin Neurosci. 2016;7(4):331-340. PMID: 27872694. https://doi.org/10.15412/J.BCN.03070406
  71. Bitsch R, Wolf M, Möller J, Heuzeroth L, Grüneklee D. Bioavailability assessment of the lipophilic benfotiamine as compared to a water-soluble thiamin derivative. Ann Nutr Metab. 1991;35(5):292-296. PMID: 1776825. https://doi.org/10.1159/000177659
  72. Ramenskaya GV, Petukhova OA, Smirnov VV. Kliniko-farmakologicheskie aspekty primeneniya preparatov vitamina B1 s razlichnoj rastvorimost’yu v zhirakh i vodnykh sredakh. Nevrologiya, nejropsikhiatriya, psikhosomatika. 2012;4(4):67-70. (In Russ.).
  73. State Register of Medicines. Accessed October 05, 2021. https://grls.rosminzdrav.ru
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